光大证券研究·2026-01-11 23:03Group 1: Small Nucleic Acid Drugs - Small nucleic acid drugs, primarily SiRNA and ASO, are entering a rapid growth phase from technological breakthroughs to large-scale commercialization [2] - The global market for small nucleic acid drugs grew from $0.1 billion in 2016 to $3.25 billion in 2021, with a compound annual growth rate (CAGR) of 217.8% [2] - It is projected that the global oligonucleotide drug market will exceed $15 billion by 2026, with a CAGR of 35% from 2020 to 2025 [2] Group 2: Blue Sky Technology - Blue Sky Technology has established a comprehensive "synthesis-purification" supply capability for small nucleic acids (siRNA/ASO) and peptide drugs [3] - The company has developed proprietary solid-phase synthesis materials and has built a technical platform that integrates high-difficulty oligonucleotide synthesis and impurity separation [3] - Blue Sky Technology plans to invest 1.15 billion yuan to build a GMP/like GMP standard biopharmaceutical industrial park and has established a subsidiary in Sweden to enhance global technical collaboration [3] Group 3: Lianhua Technology - Lianhua Technology is rapidly expanding into the small nucleic acid business, leveraging its established small molecule CDMO system [4] - The global CDMO/CMO market is expected to exceed $120 billion by 2024, with a CAGR of approximately 9.5% [4] - The company has made significant progress in international market expansion and has deepened R&D collaborations with leading global pharmaceutical companies [4]