中国医科大学最新Nature子刊：丁辰/郑倩倩团队揭示肠道真菌促进肠道再生修复的新机制

Core Viewpoint - The research highlights the role of the fungal commensal Kazachstania pintolopesii (Kp) in promoting intestinal repair through its secreted peptide, CD12, marking a significant advancement in understanding gut regeneration mechanisms and positioning gut fungi as potential biotherapeutics for inflammatory and iatrogenic bowel diseases [3][7]. Group 1 - The study confirms that the secreted protein Ygp1 from Kp plays a crucial mediating role in intestinal regeneration [6]. - A 12-amino acid peptide fragment, CD12, derived from Ygp1, is sufficient to promote differentiation of intestinal organoids and accelerate gut healing in mouse models of colitis and chemotherapy-induced damage [6]. - CD12 interacts with mammalian α-enolase (ENO1), increasing YAP1 protein levels and activating regeneration-related transcriptional programs via the Hippo signaling pathway [6]. Group 2 - The research provides a translatable delivery strategy by demonstrating that engineered probiotics expressing CD12 can replicate its therapeutic benefits [6].