Cell Res：徐瑞华院士团队等揭示甲硫氨酸代谢促进肿瘤发生的新机制

Core Viewpoint - The article discusses a novel mechanism by which methionine metabolism regulates tumorigenesis through the AHCY-adenosine complex, which rewires mRNA methylation to enhance fatty acid biosynthesis and tumor development [3][9]. Group 1: Mechanism of mRNA Methylation - m6A is the most common internal modification on mRNA in higher eukaryotes, influencing RNA stability, splicing, and translation, with dysregulation linked to various developmental diseases and cancer [2]. - The AHCY-adenosine complex increases mRNA's m6A modification levels in a non-global manner, promoting fatty acid synthesis and tumorigenesis [6][9]. - AHCY dimerization, facilitated by adenosine, is crucial for stabilizing the complex, which inhibits FTO activity and enhances m6A modification levels [7][9]. Group 2: Implications for Cancer Research - The study identifies a key "switch" in cancer metabolism, linking methionine metabolism to mRNA m6A modification, which could open new avenues for understanding and treating cancer [3][9]. - Disruption of AHCY dimerization in tumor cells inhibits tumor growth without significantly affecting methionine catabolism, indicating a potential therapeutic target [7][9]. - The findings suggest a novel connection between methionine cycle and lipid metabolism, providing new strategies for anti-cancer therapies [9].