Nature子刊：只需一个月饿上5天的模拟禁食，可缓解克罗恩病

Core Viewpoint - Fasting-mimicking diet (FMD) shows potential benefits in inducing clinical response, remission, and biochemical improvement in patients with mild to moderate Crohn's disease, outperforming standard dietary support [3][8]. Group 1: Fasting-Mimicking Diet (FMD) - FMD involves a 5-day low-calorie diet each month, designed to mimic fasting while ensuring essential nutrient intake, making it easier for individuals to adhere to [2]. - The study published in Nature Medicine indicates that FMD can significantly reduce inflammation and improve metabolic health in healthy individuals, but its effects on Crohn's disease were previously unstudied [7]. Group 2: Clinical Trial Findings - In a randomized controlled trial, 69.2% of patients in the FMD group achieved the primary outcome of a 70-point reduction in Crohn's Disease Activity Index (CDAI) compared to 43.8% in the control group [7]. - Secondary outcomes showed that 64.6% of the FMD group reached clinical remission, while only 37.5% of the control group did [7]. - FMD group exhibited a 22.0% decrease in fecal calprotectin levels, an inflammation marker, while the control group saw an 8.0% increase [7]. Group 3: Mechanistic Insights - Exploratory analyses revealed that FMD led to reductions in key inflammatory lipid mediators and immune response transcripts, correlating with decreased Crohn's disease activity [8].