施一公/李党生主编的国产顶刊Vita，上线首批文章：儿童癌症的共同起源机制；血红素缺乏触发铜死亡

Core Insights - The article discusses the establishment of a new international open-access journal named Vita, led by Westlake University, focusing on significant advancements in life sciences and biomedical research [2] - It highlights the unique characteristics of childhood cancers, emphasizing their developmental origins and the potential for a unified mechanism of onset [7][11] Group 1: Journal Overview - Vita is co-edited by Professor Li Dangsheng and Professor Shi Yigong, aiming to publish impactful research in various fields of life sciences [2] - The journal has already published two articles, including an "Expert Views" piece and a "Cutting Edge" commentary [3] Group 2: Childhood Cancer Mechanisms - The article presents a perspective on the common origin mechanisms of childhood tumors from a developmental biology viewpoint, contrasting them with adult cancers [7][9] - It identifies that childhood cancers primarily affect the hematopoietic system (e.g., leukemia) and the nervous system (e.g., brain tumors), which are most susceptible to malignancy during early development [10][11] Group 3: Developmental Vulnerabilities - The article explains that during embryonic development, tissue-forming cells (TFCs) act as "builders" of organs, and disruptions in their protective mechanisms can lead to mutations and cancer [13][14] - It discusses the similarities in the developmental processes of the hematopoietic and nervous systems, which may explain the prevalence of childhood cancers in these areas [15][16] Group 4: Future Directions - The authors suggest that understanding the developmental vulnerabilities can provide new strategies for preventing childhood cancers, including the potential use of protective molecules delivered through the placenta [21][24] - Future research directions include identifying similar genomic protection mechanisms in other organs and developing early intervention strategies for high-risk pregnancies [23][24]