《自然》：身体存有“记忆”！肥胖后的脂肪表观极难逆转

Core Viewpoint - The article discusses the phenomenon of "fat memory," highlighting that the body retains cellular changes from obesity even after significant weight loss, making it easier to regain weight [8][12][18]. Group 1: Research Findings - A study from the Swiss Federal Institute of Technology analyzed fat tissue from successful weight loss participants, revealing that transcriptional changes induced by obesity persist even two years post-weight loss [8][9]. - In mouse experiments, previously obese mice showed a heightened ability to absorb sugars and fats, leading to faster weight regain when reintroduced to a high-fat diet compared to never-obese mice [19][20]. - The study found that 57-62% of downregulated and 68-75% of upregulated differentially expressed genes (DEGs) post-weight loss could be explained by epigenetic mechanisms [18]. Group 2: Implications of "Fat Memory" - The presence of "fat memory" suggests that individuals who have been obese may face increased difficulty in maintaining weight loss, as their bodies are predisposed to regain weight more rapidly [20][21]. - The research indicates that the duration of obesity and the time taken to lose weight significantly influence the persistence of fat memory, with longer obesity periods leading to more pronounced effects [16][18].