Nature：刘河生团队等重新定义帕金森病，并提出治疗新策略

Core Viewpoint - Parkinson's disease (PD) is identified as a somato-cognitive action network disorder, suggesting that targeting the specific neural regulation of the somato-cognitive action network (SCAN) may improve treatment outcomes for PD symptoms [3][12]. Group 1: Research Findings - A study published in Nature reveals the key abnormal mechanisms of Parkinson's disease, highlighting it as a disorder of the somato-cognitive action network [3]. - The research team constructed a large clinical imaging dataset (n=863) to explore the role of SCAN in the pathophysiology and treatment of Parkinson's disease [8]. - Effective treatments, including deep brain stimulation (DBS) and transcranial magnetic stimulation (TMS), showed a reduction in the hyperconnectivity of SCAN to subcortical structures [10][12]. Group 2: Treatment Implications - Targeting SCAN rather than effector-specific regions significantly enhances the effectiveness of TMS treatment, with results showing a twofold improvement [10]. - The study indicates that the alleviation of SCAN hyperconnectivity is a core aspect of the pathophysiology of Parkinson's disease and a marker of successful neuroregulatory treatment [12]. - New non-invasive or minimally invasive neuroregulatory approaches targeting cortical SCAN nodes may improve existing therapies like DBS and MRgFUS [12].