Nature：华人学者证实，肿瘤会欺骗大脑关闭免疫系统，抑制抗癌免疫、促进癌症进展

Core Insights - The article discusses the role of the vagus nerve in tumor-brain communication and its implications for cancer immunity and progression [2][3][5]. Group 1: Tumor-Brain Communication - The study reveals a bidirectional communication between tumors and the brain mediated by the sensory-sympathetic axis, which plays a crucial role in inhibiting anti-cancer immunity and promoting cancer progression [3][6]. - Increased neural innervation of tumors is associated with poor cancer prognosis, highlighting the importance of understanding how the brain perceives and responds to tumors in peripheral organs [5][6]. Group 2: Mechanisms of Action - The research identifies a tumor-brain signaling axis that promotes tumor development by establishing an immunosuppressive tumor microenvironment [6]. - Vagal sensory neurons, which connect visceral organs to the brain, are shown to be involved in the signaling process, with specific neurons transmitting signals from lung tumors to brainstem nuclei, enhancing sympathetic output in the tumor microenvironment [6][7]. Group 3: Therapeutic Implications - Disruption of the sensory-sympathetic pathway through genetic, pharmacological, or chemogenetic methods can significantly inhibit lung tumor growth by enhancing anti-cancer immune responses [8][10]. - Targeting the tumor-brain communication pathway may provide new therapeutic strategies for visceral organ cancers [10].