STTT：卞修武院士团队等绘制人类大脑不同脑区蛋白质组图谱

Core Insights - The article discusses a recent study that created a proteomic map of different regions of the human brain, aiming to explore functional connections between these regions and establish a foundation for understanding various disease models [3]. Group 1: Research Findings - The research team conducted proteomic analysis on thirteen anatomical brain regions from eight donors, constructing a region-specific protein expression map to clarify its association with brain function [6]. - The study revealed a high interconnectivity among the four brain lobes (frontal, temporal, parietal, occipital), suggesting that large-scale neural networks facilitate information integration [6]. - A three-module functional framework was proposed, highlighting the role of the midline regulatory axis (thalamus/hypothalamus, corpus callosum, ventricles, optic chiasm) in advanced cognitive functions [7]. Group 2: Implications - The research provides molecular evidence supporting the involvement of the midline regulatory axis, brainstem, and cerebellum in higher cognitive functions, indicating their critical roles in neural development, inter-regional signal transduction, and structural homeostasis [7]. - Overall, the study enhances the understanding of brain physiological functions and emphasizes the importance of integrating proteomics with transcriptomics in research on brain function and neurological diseases [9].