ANGEL YEAST(SH:600298) synbio新材料·2026-02-13 23:01Core Viewpoint - The article discusses the development of next-generation biomanufacturing technologies based on extreme microorganisms, particularly Halomonas bluephagenes, emphasizing their potential to achieve sustainable industrial production while addressing the challenges of traditional microbial platforms [2][3]. Group 1: Need for Biomanufacturing Transition - The biomanufacturing technology using microorganisms is increasingly recognized as an environmentally friendly alternative for producing diverse chemicals, driven by advancements in synthetic biology [8]. - Current industrial biotechnology faces limitations due to high energy-consuming sterilization processes and inefficiencies in continuous production, necessitating the shift to next-generation biomanufacturing (NGIB) using extreme microorganisms [9][10]. Group 2: Industrial Value of Extreme Microorganisms - Extreme microorganisms, such as thermophiles, acidophiles, and halophiles, exhibit remarkable growth capabilities in harsh environments, making them suitable for industrial applications [11]. - These microorganisms can significantly reduce sterilization needs and enhance production efficiency, positioning them as valuable assets in sustainable biomanufacturing [14][15]. Group 3: Development of Next-Generation Industrial Biotechnology - Halomonas bluephagenes, a halophilic bacterium, shows promise in producing biopolymers like PHB, with advantages in genetic engineering and metabolic pathway optimization [13][16]. - The development of genetic tools and adaptive evolution strategies has led to significant improvements in product yields and metabolic efficiency [17][20]. Group 4: Metabolic Engineering and Product Synthesis - Metabolic engineering is crucial for enhancing the production of target metabolites in extreme microorganisms, with strategies focusing on cell morphology optimization and dynamic control of protein degradation rates [20][21]. - Halomonas bluephagenes has been engineered to utilize various low-cost substrates, including starch and food waste, for the production of biopolymers and high-value chemicals [27][33]. Group 5: Industrial Applications and Future Directions - The NGIB technology has been successfully applied in the production of biodegradable materials like PHA and various fine chemicals, with industrial-scale implementations already underway [39]. - Future advancements will require integrating cutting-edge technologies and optimizing metabolic pathways to enhance the efficiency and sustainability of biomanufacturing processes [41][43].