Nature子刊：中山大学邝栋明/魏瑗/劳向明团队揭示癌症干细胞转移新机制——中性粒细胞通过迁移体转移线粒体，塑造伪缺氧状态驱动转移

Core Viewpoint - The article discusses a newly identified mechanism by which cancer stem cells (CSCs) acquire metastatic capabilities, highlighting the role of neutrophil-derived mitochondria in shaping a pseudohypoxic state that drives metastasis [2][3][5]. Group 1: Mechanism of Metastasis - The research identifies a specific subgroup of CSCs, THY1⁺ CSCs, as key drivers of metastasis, revealing that they exist in a pseudohypoxic state independent of classical hypoxia [5][7]. - THY1⁺ CSCs maintain self-renewal through the IL-6–MYC signaling pathway, which is activated upon interaction with neutrophils, triggering a cascade of signaling events that promote their metastatic behavior [5][7]. Group 2: Implications for Cancer Treatment - Targeting the IL-6–Myc, THY1–Mac1, or Src–Akt/Erk signaling pathways could effectively inhibit the pseudohypoxia-driven metastasis of CSCs, providing potential strategies for suppressing tumor metastasis and improving cancer prognosis [5][7].