Cell：赵祥团队等通过组氨酸扫描调制TCR等机械力感应受体敏感性，为更安全的TCR-T细胞疗法奠定基础

Core Viewpoint - The article discusses advancements in T Cell Receptor (TCR) therapy for solid tumors, highlighting the challenges in developing effective and specific TCRs while addressing the potential for off-target toxicity [3]. Group 1: Research Findings - A study published in the journal Cell introduces a histidine scanning engineering strategy that significantly enhances the activation efficacy of mechanosensory receptors like TCRs [4]. - The research demonstrates that histidine scanning can identify hotspots that form additional catch bonds, allowing for the creation of a TCR library aimed at low-affinity, high-efficacy variants without off-target or on-target toxicity [6]. Group 2: Implications for Therapy - The findings provide a universal engineering method for low-affinity, high-efficacy TCRs, enabling the design of TCR libraries without structural constraints [8]. - The histidine scanning approach has broader applications in other mechanosensory ligand-receptor systems, potentially impacting various immunotherapy strategies [8].