Core Viewpoint - The research conducted by Professor Wang Geng's team at Xiamen University reveals that mitochondrial double-stranded RNA (mt-dsRNA) plays a significant role in aging-associated cognitive decline, with SEC61A1 being a key regulator of mt-dsRNA homeostasis [2][4]. Group 1 - The study published in Cell Research identifies SEC61A1 as a crucial factor that is specifically upregulated in the aging brain, enhancing endoplasmic reticulum-mitochondria contact (ERMCS) and promoting mitochondrial transcription [2][4]. - The activation of the cytoplasmic MDA5/RIG-I-MAVS innate immune pathway due to the accumulation of mt-dsRNA drives cognitive decline associated with aging [2][4]. - The research demonstrates that overexpression of Sec61a1 in the cortex of mice can induce cognitive decline without affecting motor abilities, while knockdown of Sec61a1 or Mavs can alleviate mt-dsRNA-mediated innate immune signaling and cognitive decline in aging mice [4]. Group 2 - The findings provide insights into the molecular mechanisms underlying cognitive decline related to aging and diseases, suggesting potential therapeutic targets for intervention [4].
Cell Res：厦门大学王耿团队揭示线粒体双链RNA驱动衰老相关认知衰退的新机制
生物世界·2026-02-17 00:21