Nature子刊：人类脊髓类器官，用于脊髓损伤研究和治疗

Core Viewpoint - The research conducted by Samuel I. Stupp's team at Northwestern University demonstrates that supramolecular assemblies of amphiphilic peptides can reverse paralysis symptoms in a severe spinal cord injury (SCI) mouse model, highlighting the potential for new therapeutic approaches in treating SCI [3][5]. Group 1 - The study published in Nature Biomedical Engineering details the construction of two human spinal cord organoid injury models to simulate spinal cord injuries in vitro: one simulating laceration injuries using a scalpel and the other using a compressive contusion, both leading to immediate neuronal death and glial scar formation [5]. - Treatment of the injured organoids with preclinical therapies inhibited scar formation and significantly promoted axonal regeneration, consistent with previous in vivo experimental results [5]. - The addition of microglia to the human spinal cord organoids confirmed that supramolecular nanomaterials could reduce levels of injury-related pro-inflammatory factors [5]. Group 2 - The human spinal cord organoid model developed in this research is expected to accelerate the development of therapies for spinal cord injuries and may also be applicable to other central nervous system injuries caused by trauma or disease [5].