Cell：张二荃团队等发现，恢复生物钟节律，能够延缓衰老、延长寿命

Core Viewpoint - The article discusses the complex biological process of aging and highlights recent research that identifies the circadian rhythm as a potential target for anti-aging interventions, specifically through the use of 3'-deoxyadenosine (3dA) to enhance the circadian rhythm in the hypothalamic paraventricular nucleus (PVN) [3][8]. Group 1: Research Findings - A study published in the journal Cell demonstrates that optimizing the timing of 3dA administration enhances the circadian rhythm amplitude in PVN neurons, reduces aging biomarkers, and extends lifespan in male mice [4][5]. - The study reveals that 3dA can restore circadian synchronization and hormonal rhythms, including cortisol, and significantly lowers epigenetic age [5][16]. - The research identifies RUVBL2 protein in PVN neurons as a critical target for the anti-aging effects of 3dA, with its specific knockout negating the benefits of the treatment [16][17]. Group 2: Mechanisms and Implications - The study outlines a clear pathway for anti-aging: administering specific drugs at the right time enhances the biological clock amplitude in PVN, regulates downstream gene expression via proteins like RUVBL2, and ultimately reverses multiple aging markers [19][20]. - The findings suggest that enhancing the rhythmic activity of PVN neurons can combat aging, establishing it as a sufficient condition for systemic protection against aging [18]. - This research opens new avenues for "time therapy," targeting biological clocks for anti-aging treatments, potentially leading to the development of drugs aimed at RUVBL2 and personalized timing therapies [20].