Core Viewpoint - Royalty Pharma plc has received overwhelming shareholder approval (99.9%) for its transition from an external management model to an integrated corporate structure, marking a significant milestone for the company [1][4]. Financial Impact - The internalization transaction is expected to generate cash savings exceeding $100 million in 2026 and over $175 million in 2030, with cumulative savings projected to exceed $1.6 billion over the next ten years [3][8]. - The total transaction value is approximately $1.1 billion, which includes 24.5 million shares of Royalty Pharma equity, $100 million in cash, and the assumption of $380 million in existing Manager debt [5][6]. Corporate Governance and Structure - The internalization is anticipated to enhance corporate governance, increase transparency, and align the leadership team more closely with shareholder interests [2][3]. - Following the transaction, all employees of the external Manager will become direct employees of Royalty Pharma, simplifying the corporate structure [7][8]. Shareholder Benefits - The acquisition is expected to strengthen shareholder alignment and ensure management continuity, with shares received by management vesting over 5 to 9 years [3][9]. - The internalization may also expand Royalty Pharma's shareholder base and enhance the company's valuation over time [3][8]. Background Information - Royalty Pharma has operated under an external management model since its founding in 1996, paying quarterly fees to the Manager based on portfolio receipts and security investments [7].

Core Viewpoint - Theravance Biopharma reported its financial and operational results for Q1 2025, highlighting growth in YUPELRI sales and advancements in clinical trials for ampreloxetine, while also addressing ongoing strategic reviews to enhance shareholder value [1][2][8]. Financial Performance - Total revenue for Q1 2025 was $15.4 million, entirely from Viatris collaboration revenue, which increased by $0.9 million, or 6%, compared to Q1 2024 [4][29]. - YUPELRI net sales reached $58.3 million, reflecting a 6% increase year-over-year [5][6]. - The company reported a net loss of $13.6 million for Q1 2025, compared to a net loss of $11.7 million in Q1 2024 [13][29]. Operational Highlights - The CYPRESS study for ampreloxetine is nearing completion, with final patient enrollment expected by late summer 2025 [5][6]. - Customer demand for YUPELRI grew by 5% in Q1 2025, with doses pulled through the hospital channel increasing by 48% year-over-year [6][5]. - The company presented data at the American Academy of Neurology 2025 Annual Meeting, showcasing the pharmacodynamic effects of ampreloxetine [6]. Strategic Initiatives - A Strategic Review Committee has been formed to evaluate alternatives aimed at unlocking shareholder value [8]. - The company continues to expect full-year 2025 R&D expenses between $32 million and $38 million, and SG&A expenses between $50 million and $60 million [14]. Market Context - Ampreloxetine is being developed for symptomatic neurogenic orthostatic hypotension (nOH) in patients with multiple system atrophy (MSA), with potential for significant clinical benefits [15][19]. - There are approximately 50,000 MSA patients in the US, with 70-90% experiencing nOH symptoms, indicating a substantial unmet medical need [17][18].

3 Royalty Pharma plc Q1 2025 Financial Results May 8, 2025 2 Forward Looking Statements & Non-GAAP Measures This presentation has been prepared by Royalty Pharma plc (the "Company"), is made for informational purposes only and does not constitute an offer to sell or a solicitation of an offer to buy securities. The information set forth herein does not purport to be complete or to contain all of the information you may desire. Statements contained herein are made as of the date of this presentation unless s ...

Market Overview - The American stock markets have experienced a downturn due to international tariff fears, impacting most sectors, while healthcare stocks have outperformed the general market in 2025 [1] Healthcare Sector Performance - Healthcare stocks are rising above competitors, with some appreciating by at least 30% this year, and smaller stocks seeing increases of 50% or more, indicating potential undervaluation [2] - Royalty Pharma has seen a 25% year-to-date price appreciation, with a current price of $31.37 and a 12-month price forecast of $41.60, suggesting a 32.61% upside [2][4] - CVS Health has experienced a 50% increase in share price since the beginning of the year, with a current price of $67.13 and a 12-month price forecast of $70.41, indicating a 4.89% upside [5][6] - Tempus AI has seen a 60% increase in share price year-to-date, with a current price of $47.83 and a 12-month price forecast of $61.18, suggesting a 27.92% upside [8][9] - Guardant Health's share prices have risen nearly 50% since the beginning of the year, with a current price of $43.14 and a 12-month price forecast of $48.95, indicating a 13.47% upside [11][12] Institutional Investments and Analyst Ratings - Royalty Pharma has seen significant institutional buying, with purchases rising to $748 million in Q4 2024 from $177 million in Q3 2024, and maintains a Buy rating from analysts [3] - CVS Health's short interest has fallen by over 12%, indicating increased investor confidence, and it has a Moderate Buy rating from analysts [7] - Tempus AI's quarterly revenue increased by 35.8% year-over-year to $200.7 million, with gross profit rising by 49.7% to $122.1 million, contributing to its positive analyst ratings [9][10] - Guardant Health has a consensus Buy rating from analysts, with actual revenue consistently beating estimates, although its path to profitability remains uncertain [13][14]

Financial Data and Key Metrics Changes - In Q4 2024, YUPELRI net sales increased by 10% year-over-year, reaching $66.7 million, marking an all-time high [4] - Full year YUPELRI sales totaled $239 million, with an 8% increase in net sales for 2024 and an 11% growth in demand [11][14] - Collaboration revenue grew by 8% to approximately $19 million in Q4 [32] - Operating expenses, excluding share-based compensation, increased to $22 million due to higher commercial and medical affairs spending [32] Business Line Data and Key Metrics Changes - YUPELRI's hospital performance saw doses increase by 49% year-over-year, with 285,000 redoses pulled through to hospital customers [4][13] - The hospital business accounts for roughly 10% of total YUPELRI volume, with 90% coming from community settings [77] - Ample enrollment in the CYPRESS study for ampreloxetine is on track, with expectations for expedited NDA filing [5][20] Market Data and Key Metrics Changes - TRELEGY reported full year sales of $3.5 billion, up 26% year-over-year, triggering a $50 million milestone payment [15] - The company anticipates achieving an additional $150 million in milestones from TRELEGY in 2025 and 2026 [16] Company Strategy and Development Direction - The company aims to grow YUPELRI revenue while increasing brand profitability, with potential near-term sales milestones in the U.S. and royalties from China [7] - For ampreloxetine, the focus is on completing enrollment in the CYPRESS study and preparing for an expedited NDA filing [8] - The company is committed to maximizing the value of TRELEGY and returning excess capital to shareholders [9] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about the financial position entering 2025, with $88 million in cash and no debt [39] - The company is focused on driving YUPELRI growth through strong demand generation and a patient-centered strategy [40] - Management highlighted the potential impact of ampreloxetine on patients with MSA suffering from nOH symptoms [41] Other Important Information - The company completed market research indicating a significant unmet need for better nOH therapies, with over 70% of surveyed neurologists agreeing [25] - The target product profile for ampreloxetine aligns with physician preferences, suggesting a favorable outlook if approved [28] Q&A Session Summary Question: What drove the success in the hospital channel this quarter? - The success was attributed to effective execution of strategy and wins in larger systems, with therapeutic interchange contributing to increased volume [45][46] Question: What is the trend for the hospital performance into 2025? - Q1 is typically softer, but there is a demonstrated need for YUPELRI, which may provide a tailwind [60] Question: What are the next steps for YUPELRI in China? - The company is waiting for regulatory feedback from Viatris, with a typical two-year window expected from submission to approval [62] Question: What was the nature of the recent FDA feedback on ampreloxetine? - The feedback was from a Type C meeting to clarify filing content and ensure alignment on key requirements for full approval [67] Question: What percentage of YUPELRI sales are non-hospital sales? - The hospital business accounts for roughly 10% of total YUPELRI volume, with the community setting making up the majority [77] Question: What is the bar for success for the CYPRESS readout? - A one-point change in the OHSA composite score is considered clinically meaningful for success [88]

Core Insights - Theravance Biopharma reported strong financial and operational results for Q4 and FY 2024, highlighting record net sales for YUPELRI and significant milestones related to TRELEGY [2][4][5] Financial Performance - Q4 2024 US net sales for YUPELRI reached $66.7 million, a 10% increase year-over-year, while FY 2024 total US net sales were $238.6 million, up 8% compared to 2023 [4][5] - Global net sales for TRELEGY in Q4 2024 were $853 million, marking a 16% increase, and $3.46 billion for FY 2024, a 26% increase year-over-year, triggering a $50 million milestone payment to Theravance Biopharma [3][4][5] - Total revenue for Q4 2024 was $18.8 million, entirely from Viatris collaboration revenue, which increased by 8% compared to Q4 2023 [9] Research and Development - R&D expenses for Q4 2024 were $9.5 million, compared to $8.3 million in Q4 2023, with full-year R&D expenses of $32.5 million falling within the guidance range [9][10] - The CYPRESS study is on track to enroll the final patient by mid-2025, with top-line data expected approximately six months later [4][5] Strategic Initiatives - The company formed a Strategic Review Committee to explore alternatives for unlocking shareholder value [7] - Theravance Biopharma is preparing for an expedited NDA filing post-CYPRESS readout and has received confirmation from the FDA regarding the content of a complete application [5][10] Market Position and Future Outlook - The company anticipates continued growth in YUPELRI sales, with a potential $25 million milestone payment from Viatris if YUPELRI achieves at least $250 million in US net sales in 2025 [5][10] - Royalties of up to 8.5% on TRELEGY net sales will return to Theravance Biopharma in eligible territories starting mid-2029, contributing to long-term value [5][10]