Table of Contents As filed with the U.S. Securities and Exchange Commission on December 19, 2025 Registration No. 333-290995 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 1 to FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Semnur Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) Delaware 2836 98-1659463 (Primary Standard Industrial Classification Code Number) (I ...

Table of Contents As filed with the U.S. Securities and Exchange Commission on December 19, 2025 Registration No. 333-290995 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 1 to FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Semnur Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) Delaware 2836 98-1659463 (Primary Standard Industrial Classification Code Number) Pa ...

Core Viewpoint - Scilex Holding Company is involved in a voluntary distribution of Dream Bowl 2026 Meme Coins to its common stockholders, facilitated by Datavault AI Inc, as a gesture of appreciation for their relationship [1][2] Company Overview - Scilex is focused on acquiring, developing, and commercializing non-opioid pain management products aimed at treating acute and chronic pain, as well as neurodegenerative and cardiometabolic diseases [1][4] - The company has commercial products including ZTlido, ELYXYB, and Gloperba, targeting high unmet medical needs in pain management [4][5] Product Pipeline - Scilex has three product candidates in development: - SP-102, a viscous gel for epidural injections to treat lumbosacral radicular pain, which has completed a Phase 3 study and received Fast Track status from the FDA [5] - SP-103, a next-generation lidocaine topical system for acute pain, which has recently completed a Phase 2 trial and also received Fast Track status [6] - SP-104, a low-dose naltrexone hydrochloride capsule for fibromyalgia treatment [6] Distribution Details - The distribution of Dream Bowl 2026 Meme Coins will occur on November 25, 2025, for record holders of Scilex common stock, with further instructions to be provided by Datavault AI [1][2] - The payment date for the distribution is subject to the Board of Directors of Datavault AI and may change prior to the actual payment date [2][3]

Table of Contents As filed with the U.S. Securities and Exchange Commission on October 21, 2025 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Semnur Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) Delaware 2836 98-1659463 (Primary Standard Industrial Classification Code Number) 960 San Antonio Road, Palo A ...

Table of Contents As filed with the U.S. Securities and Exchange Commission on October 21, 2025 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Semnur Pharmaceuticals, Inc. (Name, address, including zip code, and telephone number, including area code, of agent for service) Copies to: Jeffrey T. Hartlin, Esq. Elizabeth A. Razzano, Esq. (Exact name of registrant as specified in its charter) Paul Hast ...

Core Viewpoint - Scilex Holding Company has announced a strategic investment of $150 million in Bitcoin in Datavault AI Inc. to support its growth in supercomputing infrastructure and data monetization [1][3]. Company Overview - Scilex is focused on acquiring, developing, and commercializing non-opioid pain management products for acute and chronic pain, as well as neurodegenerative and cardiometabolic diseases [6][7]. - Datavault AI is positioned to leverage AI-driven analytics and blockchain technology to address challenges in data integrity and monetization across various industries, including biotech and energy [2][11]. Investment Details - The investment will provide Datavault with growth capital to expand its operations and unlock new revenue streams [1]. - Scilex is expected to receive up to 278,914,094 shares of Datavault common stock at an effective purchase price of $0.5378 per share, with specific terms regarding share issuance and board representation [4]. Market Potential - The global AI market is projected to reach $1.8 trillion by 2030, while the life sciences analytics market is estimated at $35.69 billion in 2024, growing at an 11.4% CAGR through 2030 [2]. - The biotech data monetization market is expected to reach a size of $30-50 billion by 2024, indicating significant growth potential for Scilex's investment strategy [3]. Strategic Alignment - Scilex aims to leverage its expertise in the biotech sector to guide Datavault in maximizing revenue generation while expanding its market presence [5]. - The collaboration is expected to create a marketplace for Real-World Assets (RWA) in the biotech and pharmaceutical industry, utilizing blockchain technology for ownership representation [3].

Core Viewpoint - Scilex Holding Company has signed a non-binding Memorandum of Understanding (MOU) with Biconomy.com to explore future cryptocurrency and treasury management strategies, potentially involving over a billion dollars in digital assets [1][2]. Company Overview - Scilex is focused on acquiring, developing, and commercializing non-opioid pain management products for acute and chronic pain, as well as neurodegenerative and cardiometabolic diseases [4][6]. - The company targets high unmet needs and large market opportunities with non-opioid therapies, aiming to improve patient outcomes [4]. Product Portfolio - Scilex's commercial products include: - ZTlido® (lidocaine topical system) 1.8%, approved for neuropathic pain relief [4]. - ELYXYB®, an FDA-approved oral solution for acute migraine treatment [4]. - Gloperba®, the first liquid oral version of colchicine for gout flare prophylaxis [4]. - The company has three product candidates in development: - SP-102 (SEMDEXA), a viscous gel for lumbosacral radicular pain, with a completed Phase 3 study and Fast Track status from the FDA [5]. - SP-103, a next-generation lidocaine topical system for acute pain, recently completing a Phase 2 trial [5]. - SP-104, a low-dose naltrexone hydrochloride for fibromyalgia treatment [5]. Strategic Collaboration - The MOU with Biconomy aims to establish a cryptocurrency treasury management strategy that balances security, liquidity, compliance, and yield [2]. - The collaboration is intended to create long-term value in Scilex's digital assets and support the transition to a crypto-powered economy [3].

Core Insights - Scilex Holding Company has entered into a Securities Purchase Agreement to exchange $200 million of common stock of its subsidiary Semnur Pharmaceuticals for $200 million in Bitcoin [1][2] Company Overview - Scilex is focused on acquiring, developing, and commercializing non-opioid pain management products for acute and chronic pain, as well as neurodegenerative and cardiometabolic diseases [1][7] - The company aims to address high unmet needs in the market with non-opioid therapies [7] Transaction Details - The institutional investor will purchase 12,500,000 shares of Semnur common stock at $16.00 per share, subject to adjustments for various corporate actions [2] - The transaction is expected to close around September 23, 2025, pending customary closing conditions [2] Regulatory Information - The shares sold under the SPA are not registered under the Securities Act and cannot be resold in the U.S. without proper registration or exemption [3] Strategic Partnerships - Scilex has engaged Biconomy.com to assist in developing cryptocurrency strategies, including reserve buildup and treasury management [5] Product Portfolio - Scilex's commercial products include ZTlido, ELYXYB, and Gloperba, targeting various pain management needs [7][8] - The company has three product candidates in development: SP-102, SP-103, and SP-104, focusing on non-opioid pain therapies [9][11]

Core Viewpoint - Semnur Pharmaceuticals has successfully completed its business combination with Denali Capital Acquisition Corp, transitioning to a public company to enhance growth and address non-opioid pain management needs [1][2][3] Company Overview - Semnur Pharmaceuticals, Inc. is a clinical late-stage specialty pharmaceutical company focused on developing and commercializing novel non-opioid pain therapies, particularly targeting moderate to severe chronic radicular pain/sciatica with its product candidate SP-102 (SEMDEXA™) [4][5] - The combined company will operate under the name Semnur Pharmaceuticals, Inc., with shares trading on the OTC Markets under the ticker symbols "SMNR" and "SMNRW" starting September 23, 2025 [2][7] Business Combination Details - The business combination was officially closed on September 22, 2025, allowing Semnur to access public capital markets for business growth [1][3] - Scilex Holding Company owns approximately 87.5% of Semnur's common stock post-business combination, indicating strong backing for the company's future endeavors [7] Leadership Statements - Henry Ji, Executive Chairperson of Semnur, emphasized the importance of public capital markets in enhancing business growth and fulfilling the company's mission [3] - Jaisim Shah, CEO of Semnur, expressed pride in the company's leadership in non-opioid therapeutics and the aim to accelerate access to these treatments through advancing clinical development and payer adoption [3] Product Development Focus - Semnur is advancing its second Phase 3 clinical development for SP-102, which is a novel gel formulation for epidural administration aimed at treating chronic radicular pain/sciatica [3][4] - The company is committed to increasing access to prescription non-opioid therapeutics and expanding its market presence [3]

Core Viewpoint - Scilex Holding Company announced the successful closing of a business combination with Denali Capital Acquisition Corp, resulting in the formation of Semnur Pharmaceuticals, Inc., which will focus on non-opioid pain management products [1][2][3] Company Overview - Scilex is dedicated to acquiring, developing, and commercializing non-opioid pain management products for acute and chronic pain, as well as neurodegenerative and cardiometabolic diseases [1][5] - The company aims to address high unmet needs in the market with its innovative therapies [5] Business Combination Details - The combined entity will operate under the name Semnur Pharmaceuticals, Inc., with shares trading on the OTC Markets under the ticker symbols "SMNR" and "SMNRW" [2][6] - Scilex holds approximately 87.5% of Semnur's common stock post-business combination [6] Leadership Statements - Henry Ji, CEO of Scilex, emphasized the importance of public capital markets for business growth and fulfilling the mission of addressing non-opioid pain management needs [3] - Jaisim Shah, CEO of Semnur, expressed pride in leading the development of prescription non-opioid therapeutics and aims to accelerate access to these treatments [3] Product Pipeline - Semnur's lead product candidate, SP-102 (SEMDEXA), is a novel gel formulation for epidural administration targeting chronic radicular pain/sciatica [10] - Scilex has additional product candidates, including SP-103 and SP-104, targeting acute pain and fibromyalgia, respectively [8]