Telix Pharmaceuticals (NasdaqGS:TLX) FY Conference February 26, 2026 04:40 PM ET Company ParticipantsChristian Behrenbruch - Managing Director and Group Chief Executive OfficerConference Call ParticipantsJeff Jones - Managing Director and Senior Analyst, BiotechnologyJeff JonesGood afternoon, everyone. Welcome back to the afternoon session of Oppenheimer's Annual Healthcare Conference. I'm Jeff Jones, one of the analysts on the biotech team here. I am delighted to be joined by Christian Behrenbruch, CEO of ...

Financial Data and Key Metrics Changes - The company reported a 56% growth in revenue to AUD 804 million, marking its third consecutive year of double-digit revenue growth [18][20] - EBITDA improved by 25% to AUD 216 million, driven by strong demand for Illuccix and the launch of Gozellix [20][23] - The gross margin remained stable at 53%, with 94% of gross margin generated from the precision medicine business [21][22] Business Line Data and Key Metrics Changes - Revenue from the precision medicine business increased by 22% year-over-year, contributing an additional AUD 113 million [20][23] - The precision medicine business demonstrated a 28% increase in operating profit and a 25% increase in EBITDA [23] - The company invested AUD 157 million into product development, focusing on its late-stage pipeline [22] Market Data and Key Metrics Changes - The precision medicine portfolio generated AUD 622 million in revenue, up 22% year-over-year, with sequential growth every quarter [31] - Illuccix is now available in 17 countries with reimbursement secured, and marketing authorizations in over 24 markets [35] - The company anticipates a 25% growth in its precision medicine business for 2026, driven by the full year of RLS revenue [28] Company Strategy and Development Direction - The company aims to transition to a high-value therapeutic business, with planned R&D investment in the range of AUD 200 million to AUD 240 million for 2026 [26] - The focus will remain on reinvesting revenues back into the business rather than optimizing near-term earnings per share [26][72] - The company is committed to building long-term value through disciplined capital allocation and strategic investments in R&D and commercial performance [27] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in achieving another year of roughly 20%+ revenue growth in 2026, with guidance set at AUD 950 million to AUD 970 million [28][30] - The company is focused on executing its strategic plan to grow the precision medicine business by expanding product offerings and geographic reach [35] - Management acknowledged the challenges faced with regulatory approvals but emphasized the importance of learning from these experiences to enhance future submissions [15][72] Other Important Information - The company has over 30 sponsored and collaborative studies running, with four major trials highlighted as priorities for the year [49] - The ProstACT Global study is currently recruiting for part two, with results expected to be released soon [50] - The company has made extensive changes to its management team and regulatory affairs capabilities to improve future product submissions [15] Q&A Session Summary Question: When might data for 591 be available? - Management indicated that the company is not waiting on the FDA and will disclose data as soon as it is available [56][58] Question: Insights on the two-product strategy for Illuccix and Gozellix? - The two-product strategy allows the company to manage economic needs and preferences of different customer types, adapting to changes in reimbursement environments [61][62] Question: Clarification on reinvesting earnings for future years? - Management confirmed that the majority of earnings will be reinvested back into the company for growth, particularly in R&D and commercial development [72] Question: Growth contribution from markets outside the US? - Currently, 95% of revenue is US-based, but the company expects this mix to change as it expands into other markets [78] Question: Will R&D spending be adjusted based on commercial performance? - Management stated that R&D investment is discretionary and can be adjusted based on commercial performance, focusing on priority studies [75][76]

Summary of Mirion Technologies Conference Call Company Overview - **Company**: Mirion Technologies (NYSE: MIR) - **Industry**: Nuclear Power and Radiation Therapy Key Points Industry and Market Dynamics - **Nuclear Power Segment Growth**: Approximately 47% of Mirion's revenue is derived from the commercial nuclear power industry, with a presence in over 95% of the global operating base [2][3] - **Global Electrical Generating Capacity Shortage**: The company views the current shortage as a generational tailwind for growth in the nuclear sector [3] - **AI Implications**: The integration of AI is expected to significantly impact operational efficiency and productivity within the company and the industry [3] Financial Performance and Guidance - **2026 Guidance**: The company anticipates accelerating organic growth across both segments, despite some crosscurrents such as government funding uncertainties and slower spending in nuclear labs [5][6] - **Record Orders and Backlog**: Mirion ended the previous year with record orders and backlog, indicating strong demand [6][7] - **Radiation Therapy Business Challenges**: The company faced challenges in its radiation therapy segment due to market softness in China and transitional issues in Japan, but remains optimistic about long-term growth [10][12] Growth Drivers - **Installed Base Growth**: The organic growth in the nuclear business was 11% last year, with expectations for continued double-digit growth driven by life extension and modernization of nuclear plants [45][49] - **Small Modular Reactors (SMRs)**: Orders for SMRs increased significantly, indicating a growing market, with $37 million in orders last year and expectations for further growth [52][67] - **Acquisition of Paragon Energy Solutions**: This acquisition is expected to enhance Mirion's capabilities in the nuclear sector, with Paragon projected to grow at 25% this year [78][79] Margin and Cost Management - **Margin Expansion**: The nuclear and safety segment saw a 40 basis point increase in margins to 29.4%, driven by procurement optimization and operational efficiencies [81][84] - **Long-term Margin Target**: The company aims for 30% EBITDA margins by 2028, with a focus on absorption and optimization strategies [84][87] AI and Technological Integration - **AI Initiatives**: Mirion launched 17 internal AI applications last year, with plans for further development, aiming to enhance productivity and operational efficiency [104][106] - **Software Exposure**: The company's software exposure is modest, between 5% and 7%, but is expected to grow as AI applications are integrated into operations [110][111] Future Outlook - **Nuclear Medicine Growth**: The nuclear medicine segment is expected to grow, driven by advancements in theranostics and radiopharmaceutical therapies [133][135] - **Emerging Trends**: Key trends include the increasing demand for electrical generating capacity and the transformative impact of AI on the industry [158][159] M&A Strategy - **M&A Pipeline**: Mirion plans to focus on smaller acquisitions to enhance its nuclear exposure while managing leverage, currently at 3.2 times EBITDA [148][150] Conclusion - Mirion Technologies is well-positioned to capitalize on growth opportunities in the nuclear power and radiation therapy sectors, with a strong focus on AI integration, margin expansion, and strategic acquisitions to drive future growth [159][160]

Molecular Partners (NasdaqGS:MOLN) Conference Call Summary Company Overview - **Company**: Molecular Partners - **Focus**: Development of DLL3 targeting radiotherapeutic, specifically MP0712 - **Collaboration**: 50/50 partnership with Orano Med for research and development Key Industry Insights - **Therapeutic Area**: Small cell lung cancer (SCLC) - **Target**: DLL3, a validated target for T-cell engagers and antibody-drug conjugates (ADCs) - **Need for Radiotherapy**: Current treatments (T-cell engagers and ADCs) do not cure cancer in SCLC patients, highlighting the need for additional therapeutic options [6][7][8] Core Data and Findings - **Clinical Imaging and Dosimetry**: Data presented at the Theranostics World Conference in South Africa showed promising results for MP0712, indicating effective targeting of DLL3 with a unique approach to enhance internalization and retention [2][4][8] - **Imaging Results**: - Lead-203 imaging demonstrated significant tumor accumulation in preclinical models and initial human data [9][10] - Higher uptake in liver metastases compared to primary tumors was observed, consistent with findings in other cancer modalities [56][58] - **Dosimetry**: - Absorbed doses for kidneys and red marrow were within acceptable limits, allowing for potential dose escalation in future phases [19][20][87] - The expected starting dose for phase 1 is 75 megabecquerels, with potential escalation to 200 megabecquerels [21][28] Safety Monitoring - **Monitoring Strategy**: Weekly blood draws to monitor hematological recovery, particularly focusing on lymphocyte and white blood cell counts [38][54] - **Expected Recovery**: Anticipated recovery of bone marrow within 2-3 weeks post-treatment, allowing for re-dosing [39][54] Future Outlook - **Phase 1/2 Trial**: Screening for patients is set to begin shortly, with updates on safety expected in the first half of the year and activity data in the second half [29][71] - **Combination Therapies**: Potential for MP0712 to be used in combination with immune-oncology agents (e.g., PD-1 inhibitors) due to the inflammatory response generated by the treatment [67] - **Actinium-225 Consideration**: Future exploration of Actinium-225 as an alternative isotope for treatment, contingent on clinical data from Lead-212 [78] Additional Considerations - **Unique Positioning**: The ability to gather data before significant investment in phase 1 trials is a strategic advantage for Molecular Partners [27] - **Investor Confidence**: The promising biodistribution and tumor retention data are expected to enhance investor confidence and shareholder value [30][32] Conclusion Molecular Partners is advancing its DLL3 targeting radiotherapeutic, MP0712, with encouraging early data from clinical imaging and dosimetry studies. The company is poised to enter phase 1 trials, with a focus on safety and efficacy in small cell lung cancer patients, while also exploring combination therapies and alternative isotopes for enhanced treatment outcomes.

Industry Overview - The Zacks Medical - Dental Supplies industry is expected to maintain upward momentum in 2026 due to innovation, an aging population, and normalized orders post-COVID-19 [1] - The global medical supplies industry is projected to reach $163.5 billion by 2027, growing at a CAGR of 3.4% from 2022 to 2027 [4] Technological Advancements - Continued adoption of digital services and AI-enabled tools is anticipated to enhance patient experience and reduce administrative burdens for physicians [2] - Innovations such as CAD/CAM systems, 3D imaging, and AI diagnostics are expected to improve treatment efficacy and broaden product use [8] Market Trends - The industry is shifting towards higher-margin specialty areas like oncology and urology, with precision health and theranostics emerging as significant trends [3] - There is a growing emphasis on preventive care and minimally invasive procedures, which is expanding market segments for dental consumables [9] Regional Growth Drivers - Emerging markets, particularly in Asia-Pacific, are benefiting from increased healthcare expenditure and improved access to care, contributing to faster growth rates [10] Economic Factors - Strong healthcare infrastructure and higher disposable income in developed regions support the adoption of advanced dental products [11] Challenges - U.S. tariffs have raised costs on essential imported dental supplies, leading to increased prices and supply-chain disruptions [12] - The industry is responding by shifting supply chains towards domestic production to mitigate tariff exposure [13] Company Performance - The industry has outperformed its sector with a collective gain of 6.6% over the past year, compared to the Zacks Medical sector's rise of 1.9% [16] - The industry is currently trading at a forward P/E of 17.67X, lower than the S&P 500's 22.81X [19] Company Insights - West Pharmaceutical is expected to maintain growth momentum in 2026, driven by demand for high-value products and operational improvements [21][22] - McKesson anticipates revenue growth of 11-15% in fiscal 2026, supported by strong demand in specialty distribution [30] - Cardinal Health expects revenues from its Pharmaceutical segment to grow 15-17% year-over-year, with challenges from competitive pricing pressures [35] - Align Technology is positioned for growth in 2026 due to restructuring actions and technological innovations, with a projected revenue increase of 3.7% [42]

Core Insights - Telix Pharmaceuticals reported fiscal 2025 revenue of approximately $804 million, meeting its upgraded guidance of $800-$820 million [1] - The company experienced a significant 46% year-over-year increase in fourth quarter revenue, totaling around $208 million [2] - The Precision Medicine business generated approximately $161 million in revenue, reflecting a 4% quarter-over-quarter growth driven by the successful U.S. launch of Gozellix [2] Financial Performance - Fiscal 2025 revenue was approximately $804 million, aligning with guidance [1] - Fourth quarter revenue increased by 46% year-over-year to around $208 million [2] - Precision Medicine revenue was approximately $161 million, with a 4% quarter-over-quarter growth [2] Clinical Advancements - The company is advancing clinical studies, including the ProstACT Global Phase 3 study and the SOLACE Phase 1 study in the U.S. [3] - Telix dosed the first patient in the U.S. for the BiPASS Phase 3 trial to evaluate its PSMA-PET imaging agents [4] Strategic Collaborations - Telix announced a strategic collaboration with Varian to explore the combination of its radiopharmaceuticals with external beam radiation therapy [5] Stock Performance - Telix stock is currently trading 5.5% below its 20-day simple moving average and 22.6% below its 100-day SMA, indicating a bearish trend [6] - Over the past 12 months, shares have decreased by 56.91% [6] - The stock carries a Buy Rating with an average price target of $21.20, despite trading at a premium P/E multiple [8] Analyst Insights - Analysts view the shift from a diagnostic-focused business to a pure-play radiopharmaceutical company as a positive development [9] - The bull case for Telix is based on the potential for durable cash flows from Illuccix and Gozellix [9] Market Position - Telix Pharmaceuticals' Benzinga Edge scorecard indicates a challenging outlook, with low momentum and a premium value score [10] - The stock was down 6.86% at $7.20 at the time of publication [11]

Core Insights - Telix Pharmaceuticals has announced a strategic clinical collaboration with Varian, a Siemens Healthineers company, to develop novel clinical applications that integrate Telix's theranostic products with external beam radiation therapy (EBRT) [1][2]. Group 1: Collaboration Details - The collaboration aims to enhance the role of EBRT in cancer treatment by integrating therapeutic radiopharmaceuticals and precision diagnostics, potentially improving patient selection and targeted treatment delivery [2][4]. - The initial focus will be on PSMA-PET imaging for prostate cancer radiotherapy patients, utilizing Telix's Gozellix® and Illuccix® products to develop personalized treatment plans and monitor treatment responses [3][4]. Group 2: Future Opportunities - The partnership is structured as a general framework for future co-development opportunities, which may include other PET imaging candidates in Telix's pipeline, such as TLX250-CDx and TLX101-CDx, as well as future therapeutic radiopharmaceuticals [4]. - By combining Telix's expertise in molecular imaging with Varian's leadership in radiation therapy, the collaboration aims to advance personalized cancer care and improve patient outcomes [5]. Group 3: Company Background - Telix Pharmaceuticals is a biopharmaceutical company focused on developing and commercializing therapeutic and diagnostic radiopharmaceuticals, headquartered in Melbourne, Australia, with operations in multiple countries [20]. - Varian, as a Siemens Healthineers company, has over 75 years of experience in developing technologies for cancer treatment, supporting various stages of the cancer care journey [22].

Core Insights - GE HealthCare (GEHC) and the University of Rochester Medical Center (URMC) have established a seven-year Care Alliance to enhance advanced imaging, precision medicine, and patient monitoring across UR Medicine [1][7] - The collaboration aims to improve operational efficiency, support technology upgrades, and standardize clinical workflows [2] Company Developments - The Care Alliance will strengthen GEHC's competitive position by deepening its presence in a major regional health system, ensuring multi-year visibility on equipment deployments, software upgrades, and recurring service revenues [4] - GEHC's current market capitalization stands at $38.08 billion [5] Technological Advancements - The partnership will implement upgrades across URMC's MRI fleet and introduce new GEHC MRI systems featuring on-device AI, which will reduce noise and shorten scan times [8][9] - The agreement includes advanced systems such as the Aurora SPECT/CT and dual-energy CT for cardiac scans, enhancing GEHC's service and lifecycle management at URMC [9] Market Positioning - The Care Alliance expands GEHC's influence in the precision medicine and theranostics market, particularly with URMC's plan to acquire an on-site cyclotron, which complements GEHC's molecular imaging ecosystem [10] - The deployment of Carescape ONE monitors and the Carescape Canvas platform will standardize patient monitoring across UR Medicine, enhancing workflow efficiency and patient safety [11] Stock Performance - Following the announcement of the Care Alliance, GEHC's shares remained flat, with a year-to-date gain of 6.9%, outperforming the industry growth of 3.4% [3]

Financial Data and Key Metrics Changes - The company reported a total revenue increase of 22% to $64 billion, driven by strong demand in pharmaceuticals and growth across all five operating segments [10][11] - Operating earnings grew by 37% and EPS increased by 36%, with Q1 EPS reported at $2.55 [9][10] - Gross profit rose by 22% to $2.3 billion, while SG&A expenses increased by 14% to $1.5 billion [10][11] - The effective tax rate for Q1 was 21.9%, about 100 basis points better than the previous year [11] Business Line Data and Key Metrics Changes - Pharmaceutical and Specialty Solutions segment revenue increased by 23% to $59 billion, with segment profit rising by 26% to $667 million [12] - The GMPD segment saw a revenue increase of 2% to $3.2 billion, with profit rising to $46 million [13][14] - Other businesses reported a revenue increase of 38% to $1.6 billion and a profit increase of 60% to $166 million [15] Market Data and Key Metrics Changes - The company experienced strong pharmaceutical demand across brand, specialty, generics, and consumer health, with approximately 6 percentage points of revenue growth attributed to GLP-1 sales [12] - The GMPD segment faced slight headwinds from tariffs, which are expected to increase in Q2 [14][20] Company Strategy and Development Direction - The company is focused on expanding its Specialty Alliance and integrating Solaris Health to enhance its multi-specialty platform [6][24] - Investments are being made to modernize the national pharmaceutical distribution network and improve service levels [23] - The company is committed to innovation and expanding its service offerings, particularly in home health care and biopharma solutions [28][30] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the strong demand environment and the company's ability to capitalize on it, with an increased EPS guidance range of $9.65 to $9.85 for the fiscal year [10][17] - The company anticipates continued strong demand in pharmaceuticals and specialty solutions, with a focus on operational execution and efficiency [23][30] Other Important Information - The company generated $1.3 billion in adjusted free cash flow during Q1 and returned $500 million to shareholders through dividends and share repurchases [16] - The company is increasing its adjusted free cash flow guidance to a range of $3 billion to $3.5 billion for the full year [17] Q&A Session Summary Question: Broader momentum and M&A contribution - Management highlighted strong demand trends and the contribution of MSO platforms to growth, with Solaris Health expected to add approximately 3% to the overall growth [33][40] Question: Policy changes and opportunities - Management noted that policy changes aimed at improving access to affordable healthcare could be neutral to positive for the company, driving utilization [46][48] Question: Growth outlook for Pharmaceutical and Specialty Solutions - Management indicated that while strong growth is expected, it will not be outsized compared to historical levels, with a focus on operational improvements [52][54] Question: Competitive landscape changes - Management acknowledged that a competitor's divestiture could create opportunities, but emphasized the importance of service level and performance [90][91] Question: MSO assets and drug spending trends - Management confirmed that specialty growth is broad across therapeutic areas, with a focus on autoimmune, neurology, and oncology [95][96]

Core Viewpoint - Perspective Therapeutics, Inc. has initiated the treatment of the first patient in the second cohort of its Phase 1/2a trial for the radiopharmaceutical [Pb]PSV359, targeting solid tumors expressing fibroblast activation protein alpha (FAP-α) [1][3] Group 1: Clinical Trial Details - The second cohort of the trial involves patients receiving [Pb]PSV359 at a dose of 5.0 mCi for up to four doses every eight weeks, with a recommendation from the Safety Monitoring Committee to evaluate higher doses based on initial patient responses [2][5] - The primary objective of the trial is to assess the safety and tolerability of various doses of [Pb]PSV359, aiming to determine the recommended Phase 2 dose for further study [5] Group 2: Mechanism and Targeting - [Pb]PSV359 is designed to target tumor sites expressing FAP-α, which is associated with several prevalent solid tumors, providing a potential treatment option for patients with limited alternatives [4][6] - FAP-α is predominantly expressed on cancer-associated fibroblasts in the tumor microenvironment and is linked to poor prognosis in various solid tumors, including pancreatic and colorectal cancers [6] Group 3: Company Overview - Perspective Therapeutics, Inc. specializes in developing radiopharmaceuticals that utilize alpha-emitting isotopes to deliver targeted radiation to cancer cells, enhancing treatment efficacy while minimizing toxicity [7] - The company is also advancing complementary imaging diagnostics that utilize the same targeting moieties, facilitating personalized treatment approaches [7][8]