Taking up motorcycle riding in his 70s filled one writer’s spirit with joy and made his anxieties about aging disappear. https://t.co/WbqOy9K9dW ...

Personal Well-being & Longevity - Excitement is crucial for longevity and overall happiness [1][2][5] - Prioritizing sufficient sleep, around 6-8 hours, enhances productivity and mental presence [10] - Physical activity, such as yoga or dancing, is essential for both mental and physical well-being [23][27] - Continuous learning and skill development are vital for adapting to change and maintaining mental agility [24][25][26] Financial Planning & Security - Savings and investment, starting with 10% of income, are important for long-term financial security and happiness [11][15][16] - Long-term, passive investment strategies, such as SIPs and mutual funds, are recommended [15] Interpersonal Relationships & Social Engagement - Building and maintaining relationships with friends and colleagues is crucial for avoiding loneliness and fostering a supportive network [19][20][22] - Social interaction and relationship building contribute to overall happiness and well-being [17][19][20] Time Management & Productivity - Effective time management is key to productivity, managing work-life balance, and building relationships [17][21] - Living in the present moment and focusing on timely task completion enhances productivity [8][9]

Longevity Research & Development - The longevity drug development race is underway, with significant investment in the field [2][25] - Since 2020, $40 billion (USD) has been invested in longevity research and biotechnology [4] - Research areas include DNA, cells (mitochondria, cellular communication, inflammation), and physiology (hand grip, squat ability, oxygen consumption) [6] - Algorithms are expected to gain FDA approval faster than biologics, offering personalized health insights [17] Cardiovascular Health & Longevity - Cardiovascular health is highlighted as the single greatest predictor of life expectancy [8] - Optimal heart health at age 50 can lead to 14 additional years of life compared to the average person, and reduce the risk of premature death by 87% [9] - Improving cardiovascular risk factors (cholesterol, blood pressure, blood sugar, weight) can add years to one's life [10][11] - The EKG, combined with AI, can estimate biological age and track the impact of lifestyle changes [13][14][16] Practical Recommendations - Focus on managing cardiovascular risk factors, especially high blood pressure, as a key strategy for extending lifespan [20][21][23] - Even fit individuals are not immune to arterial stiffening and should monitor their blood pressure [22][23]

Core Argument - The central argument is that aging should be treated as a disease, warranting the same level of research and resources as other deadly conditions [1][2][3] - The industry aims to shift public perception, as currently only 41% of Americans believe medical treatments to slow aging would be beneficial for society [3] - The industry emphasizes the need to convince investors and politicians about the value of longevity research, given that over half of Americans may not support it [5][6] Ethical Considerations & Counterarguments - The industry addresses concerns that aging research will only benefit the wealthy by arguing that aging affects everyone, and the solution is to expand access to healthcare, not limit it [8][9] - The industry refutes the argument that a growing older population will deplete Earth's resources, citing advancements in sustainable technology and the low consumption rates of long-lived societies [10][11][12] - The industry challenges the notion that longer lifespans will bankrupt social security systems, highlighting the potential for older individuals to remain productive and contribute trillions of dollars to the GDP [13][14] - The industry addresses the concern of competing healthcare priorities by reiterating that aging is a root cause of many diseases, making it a crucial area for investment [15][16] Societal Impact - The industry argues that social structures should adapt to changing needs, as they already have, rather than hindering progress in longevity research [18][19] - The industry dismisses the idea that progress will stagnate with longer lifespans, pointing to the current rapid pace of technological change despite increasing longevity [20][21] - The industry counters the existential argument that life's meaning is tied to its finite nature, asserting that value comes from contributions and engagement, which can be amplified by a longer life [21][22][23] - The industry challenges the notion that fighting death is unnatural, comparing it to other accepted medical interventions like antibiotics and organ transplants [23][24] Call to Action - The industry advocates for expanding healthspan and lifespan research to uncover the root causes of diseases and increase the number of years people can actively contribute to society [26] - The industry urges stakeholders to advocate for aging research and increase public support from 41% to 100%, emphasizing its potential to improve the world [27]

[applause] For 5,000 years, humans have been trying to solve one thing. Not cancer, not aging, not heartbreak, the hangover. The history of hangover cures reads like a comedy of errors.Ancient Egypt dried bird beaks. The Greeks laurel reefs soaked in olive oil. Mongolia tickled sheep eyeballs in tomato juice.Today we call that the bloody mary. [laughter] Alcohol isn't just a drink. It's woven into all cultures.It marks celebrations and connections. And it's part of everyday life. But the biggest myth of all ...

Core Argument - The healthcare industry currently focuses on treating chronic diseases rather than preventing them [4] - The industry should shift its focus from disease treatment to investigating resilience, defined as the ability to robustly respond to insult or injury [6] - Centenarians, individuals who live to 100 years or more, exemplify exceptional longevity and provide a blueprint for healthy aging [7] Research & Development - Induced pluripotent stem cells (iPS-CEs) can be used to create disease models and investigate resilience mechanisms [2][8] - Researchers can create "centenarians in a dish" using iPS-CEs from centenarians to study their resistance to aging-related diseases [7][8] - Centenarian neurons exhibit more stable activity, reduced background noise, and operate in a more energy-efficient state compared to normal individuals [12][13] Potential Applications & Future Directions - iPSC master stem cell modeling can identify new biomarkers of aging and facilitate preclinical screening of novel therapeutics aimed at increasing longevity and health span [18] - Developing novel therapeutics ("geroprotectors") can increase resilience and health span, potentially through personalized clinical trials using an individual's own cells [18] - Lifestyle choices such as not smoking, exercising, and practicing preventative medicine can contribute to a more centenarian-like existence [17]

For 5,000 years, humans have been trying to solve one thing. Not cancer, not aging, not heartbreak, the hangover. The history of hangover cures reads like a comedy of errors.Ancient Egypt, dried bird beaks. The Greeks laurel reefs soaked in olive oil. Mongolia pickled sheep eyeballs in tomato juice.Today we call that the bloody Mary. Alcohol isn't just a drink. It's woven into nearly every culture.It marks celebrations and connections and everyday life. But the biggest myth still lives on. This hangover is ...

Core Argument - The prevailing aging models inadequately address the role of persistent pathogens (viruses, bacteria, parasites) as a significant driver of human aging and healthspan reduction [1] - Persistent pathogens can embed themselves in tissues and nerves, potentially driving various health problems later in life [2][3][4] - These pathogens can actively distort the signaling of human genes, impacting multiple hallmarks of aging [8] Pathogen Prevalence and Impact - Approximately 95% of individuals harbor one or more strains of herpes virus [5] - Around 11% of people in the US and up to 87% in some global regions carry the chronic parasite toxoplasma [6] - Persistent SARS-CoV-2 virus has been found in tissue samples months or years after initial infection [7] - Pathogens can drive mitochondrial dysfunction by hijacking host cell metabolism [10][11][12] - Viruses can integrate into telomeres, leading to shorter and more unstable telomeres [13][14] - Viral proteins can interact with and distort the signaling of human aging pathways [15] Proposed Solutions and Recommendations - The industry needs to seriously consider the impact of persistent pathogens when developing healthspan extending interventions [17] - Curbing the activity of pathogens should precede interventions like gene editing [18] - Integrating existing antiviral and anti-parasite medications into healthspan protocols is recommended [18] - Individuals with herpes simplex virus who regularly took anti-herpes virus medications had a 10 times lower risk of developing dementia [19] - Investment in new diagnostic test platforms to identify persistent pathogens is crucial [20][21] - Incorporating the activity of persistent pathogens into aging models is essential for successfully extending healthspan [22]

Future generations will wonder how we were ever ok with thisLinus Petersson (@LinusPeters):110k will die of aging today ...

Asian people are the elves of the human race:> says she’s 42> actual age probably 52 since lying> looks 28What is the best advice to not visibly age?Irene Zhao (@Irenezhao_):I am 42 years oldwhat is the best advice you can give me? https://t.co/Rf2VRtgtVn ...