Technology & Innovation - AI is being used to manage large gatherings and process vast amounts of data, transforming data into information, knowledge, and wisdom [1] - Predictions suggest cell phones may become obsolete, replaced by devices like spectacles with advanced capabilities [1] - Meat can now be grown in labs from basic ingredients, offering vegetarian alternatives to non-vegetarian food [1] - DNA sequencing is becoming more accessible at under $100, enabling insights into ancestry and disease prediction [1] - Gene editing and cell therapies, like CAR T-cell therapy, are advancing predictive and preventive medicine, with successful treatments for genetic defects and cancer [1] Business & Success Factors - Success is often attributed to the ability to take risks, as exemplified by figures like Bill Gates and Steve Jobs [2][3][4] - Bill Gates, after dropping out of Harvard, co-founded Microsoft and became the world's youngest self-made billionaire with a net worth of 125% billion [3] - Steve Jobs, who dropped out of Reed College, co-founded Apple, which later fired him but he returned 12 years later [4][5] - Key rules for success include learning from winners, taking risks, and having fun while staying connected [9][10][11] Personal Development & Ethics - Individuals should trust their own judgment and abilities when making decisions about their careers and lives [1] - Honesty and integrity are crucial, as illustrated by the story of Subramanyam Chandrasekhar, who later won the Nobel Prize [15][16] - Humility is important, as demonstrated by the encounter between Dilip Kumar and JRD Tata [17][20]

My DNA results are in:B BN NBN NB BN NBN NB BN NBN NB BN NBN NB B ...

AI Model Capabilities - AI models, like the EVO2 model from the Ark Institute, can ingest trillions of base pairs of DNA data to identify patterns [1] - These models can identify pathogenic variants in DNA, such as the BA gene variant linked to breast cancer, without prior knowledge or training [2] - AI's ability to identify patterns in DNA suggests potential for uncovering insights into complex phenomena in nature, society, and behavior [3] Limitations and Context - The EVO2 model lacked context for what the DNA represented, including the concept of genes and structured understanding of DNA function [2] - The model's success in identifying the pathogenic variant occurred without knowledge of pathogenic variants for cancer [3]

[Musica] Professore, il professore mi ha fregato, è stato più veloce di me, però recuperiamo solo il Ecco, così lo presento. Professore di biologia e genetica presso l'Università Link, presidente del Comitato Nazionale per la bioetica dal 2022 e oggi ci parlerà di un argomento complesso scientifico, ma sono sicuro che ce lo farà capire molto bene. Grazie.Facciamogli un applauso. Una una delle foto più brutte in assoluto della mia vita. Vai.Comunque eccoci qua. Allora, non voglio assolutamente confondervi. H ...

DNA Sequencing & Personalized Medicine - DNA analysis can reveal individual predispositions to diseases, drug effectiveness, and metabolic rates, paving the way for personalized medicine [1][3][4] - Current hospital DNA sequencing typically reads short sequences (around 250 letters), while advanced technologies can read over 1 million letters, significantly improving accuracy [10] - The Telomir consortium successfully sequenced the remaining 8% of the human genome previously missing from databases [12][13] - Complete chromosome sequencing, including the Y chromosome, is now achievable, providing comprehensive genetic information [13][14] Genomic Insights - Human DNA consists of 3 billion letters from each parent, with variations occurring roughly every 1 in 1,000 letters compared to every 1 in 100 letters in chimpanzees [5][6] - DNA, viewed as a text file, occupies only 6 GB of storage, highlighting the manageability of genomic data [7][8] - Telomeres, repetitive DNA sequences protecting chromosome ends, shorten with each cell division (approximately 50 divisions), acting as a safeguard against uncontrolled cell proliferation [14][15] - Imbalances in chromosome numbers due to centromere issues can lead to early embryonic development problems and increased miscarriage risk [17][18] - Repetitive DNA regions on chromosomes 13, 14, 15, 21, and 22 are prone to rearrangements, potentially causing conditions like Down syndrome, occurring in approximately 1 out of 800 births [18][19] Challenges & Future Prospects - Despite technological advancements, only a few labs globally have expertise in complete chromosome sequencing, and the cost remains high (over 100,000 Czech Koruna per genome) [28] - The integration of complete DNA sequencing into healthcare records and personalized medicine faces challenges due to community conservatism and limited experience [20][21][29] - The industry anticipates that decreasing costs and increased informational value will drive the adoption of complete DNA sequencing, leading to personalized medicine approaches [29][30]

Gene Editing Technology & Applications - CRISPR technology, inspired by the Nobel Prize-winning discovery of Jennifer Doudna and Emmanuelle Charpentier, functions as a programmable editor to repair genetic defects [5][6] - The technology utilizes a CRISPR protein and guide RNA complex to target and precisely repair problematic DNA sequences [7][8] - Ultra-compact CRISPR systems have been developed to overcome delivery challenges, particularly for tissue-specific delivery via AAV [12][13] - The first FDA-approved CRISPR therapy involves editing blood stem cells outside the body to treat sickle cell disease [14] Delivery Systems - Two primary gene delivery systems exist: Lipid Nanoparticles (LNPs) and Adeno-Associated Viruses (AAVs) [10] - LNPs act as cargo ships, carrying large CRISPR components, primarily docking in the liver [10][11] - AAVs function like drones, delivering smaller CRISPR payloads to specific cell types while minimizing immune responses [11][12] Challenges & Future Directions - Access to cells and tissue types beyond the liver remains a significant challenge for widespread CRISPR deployment [9][16] - Addressing the safety, efficacy, scalability, and accessibility of CRISPR medicines for over 5,000 known genetic diseases is crucial [16] - Advances in AI are accelerating the development of next-generation CRISPR medicines [17] - The industry envisions a future where curing genetic diseases becomes as simple as pairing an ultra-compact CRISPR system with a targeted delivery method [17][18]

Scientific Discovery - New discoveries expand the timeline of proteins available for analysis ten-fold compared to DNA [1] - Palaeontologists can now understand organisms that are too old for other ancient molecular analysis [1]

RT vittorio (@IterIntellectus)holy shit, it’s here!deepmind just released AlphaGenome.an AI model that reads 1 million bases of DNA and predicts how any mutation changes molecular functionnot just in single genes but across the entire regulatory genome.DNA is code, and you are software1/ https://t.co/f3zQAJUrdK ...