Pipeline and Milestones - Prothena has multiple clinical programs ongoing, including one partnered Phase 3 program, two partnered Phase 2 programs, one partnered Phase 1 program, and one wholly-owned Phase 1 program[13] - Prothena is eligible to receive up to $1.23 billion in total consideration from Novo Nordisk for coramitug and the broader ATTR amyloidosis program[13, 16] - Prothena anticipates up to $105 million in clinical milestones in 2026, including completion of Phase 3 development for prasinezumab and initial data from the Phase 1 ASCENT trial for PRX012[18] Partnerships and Financials - Prothena's partnerships are expected to generate meaningful value, with up to $755 million in total milestones and royalties for prasinezumab, up to $1.23 billion for coramitug, and up to $1.55 billion across two clinical-stage programs (BMS-986446 and PRX019)[20] - Bristol Myers Squibb (BMS) owns approximately 2.2% of Prothena's outstanding shares as of March 3, 2025[21] Alzheimer's Disease Programs - PRX012, Prothena's anti-Aβ candidate, has approximately 10X greater binding potency to fibrillar Aβ vs aducanumab and approximately 20X greater binding potency against protofibrils vs lecanemab[24] - BMS-986446 (formerly PRX005), an anti-tau candidate, has the potential to reduce pathogenic tau spread in Alzheimer's disease[27] - PRX123, a dual Aβ/tau vaccine candidate, is designed for both treatment and prevention of Alzheimer's disease, and its IND has been cleared[27] Parkinson's Disease Program - Roche will initiate Phase 3 development for prasinezumab in early-stage Parkinson's disease[15, 111] - The Parkinson's disease affects >10 million people worldwide and represents an overall economic burden of $52 billion in the US[5] ATTR Amyloidosis Program - Coramitug (formerly PRX004) is in Phase 2 development for ATTR amyloidosis with cardiomyopathy (ATTR-CM)[15, 142] - An estimated 450,000 patients worldwide have wtATTR or ATTRv[8]

2025年的日历翻过一半，上海二手房半年战绩出炉：13.01万套，创下近四年来的新高。较2024年上半年的10.89万套增长 19.5%。 01 近四年来的半年峰值 2025年1-6月，上海二手房网签成交（含商业、车位等）累计成交13.01万套，较2024年同期的10.89万套，增长19.5%。并 且超越2022年、2023年同期，是近四年来的半年成交峰值。 今年上半年，上海二手房月均成交超2万套，其中3月成交达29353套，四年来仅次于2024年12月的29711套。 | | 2025年上半年上海二手房月签约套数 | | --- | --- | | 月份 | 网 签复数 | | 1月 | 18379 | | 2月 | 16742 | | 3月 | 29353 | | 4月 | 23506 | | 5月 | 21352 | | 6月 | 20774 | 02 6月成交回落，但仍在稳定区间 刚刚过去的6月份，二手房成交20774套，同比下降21%，打断了连续14个月同比增长的态势。 这一看似显著的回落，主因在于去年同期基数异常高企：2024年6月正值"沪十条"新政落地首月，政策刺激下市场情绪高 涨，集中签约，单 ...

Enterprise said the US government has removed license requirements for shipping ethane to China, clearing the way for deliveries to the country’s ports without additional approvals https://t.co/lJOgsTCxom ...

Welcome back to Squawk on the Street. Well, America's biggest banks are on a winning streak. Wells, Goldman, Morman Stanley, and more are just inches from hitting their new all-time highs after passing the Fed's latest stress tests late last week and boosting shareholder payouts yesterday after uh the close.Those are the how far they are from all-time highs as we stand, but they're having a decent couple of trading sessions. So what's uh on the deck for banks in the second half of the year. UBS managing dir ...

NOW: 🇺🇸 SEC Chair Paul Atkins claims that "the rules have not been clear" around crypto regulation.Atkins adds that his goal is to "make things transparent from the regulatory aspect." https://t.co/fjcW5Hxf8t ...

In the northwest corner of Los Angeles County, one of America's largest landfills has been overheating to dangerous levels, and the neighbors are getting sick. There have been reports of headaches, nausea, and a cluster of new cancer cases. In 2022, buried pockets of waste at Chita Canyon Landfill started climbing to broiling temperatures well above safety standards, according to a state assessment.Since then, officials say the hot temperatures have consumed about 90 acres of the landfill, spewing out stron ...

We're speaking with the SEC chairman Paul Atkins and we're thrilled to have him at the table. I have a question because about insider trading, an issue that the SEC has always sort of oversaw, but there hasn't been a huge number of insider trading cases uh in recent years. I mean, not not big famous ones, but there's this whole crypto industry that is not really regulated.And I'm curious what you think of that, which is to say that there's lots of people doing things. And I the reason I mentioned this is th ...

We are uh joined right now at the table by SEC Chairman Paul Atkins. We're thrilled to have you. Thanks for having a lot going on in Washington uh as as you know, drinking from a fire hose at this point.And we've got about a million questions about the market, about what you're doing, about what the regulatory landscape looks like. And so there's so many different places we can go. I wanted to start with actually something that happened on this set yesterday, if you'd indulge me.um only because it was such ...

The states have stepped in repeatedly on AI regulation to fill the void created by inaction in Washington and have a vital role to play, @DaveLeeBBG says (via @opinion) https://t.co/nqg5aYNfkz ...

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