Visionary Innovation Riad Sherif, M.D. Chief Executive Officer J.P. Morgan Healthcare Conference January 14, 2026 Safe Harbor Statements Cautionary note on forward-looking statements These slides and the accompanying oral presentation contain forward-looking statements and information. The use of words such as "may," "might," "will," "should," "expect," "plan," "anticipate," "believe," "estimate," "project," "intend," "future," "potential," or "continue," and other similar expressions are intended to identi ...

Core Insights - Natera is focused on transforming healthcare through innovative genetic testing and precision medicine solutions, collaborating with NVIDIA to enhance its AI capabilities [1][2] - The partnership with NVIDIA aims to leverage advanced AI technology for more accurate and personalized medical solutions, reflecting Natera's commitment to integrating cutting-edge technology [2][4] Company Performance - Natera's stock price was $234.31 at the time of the NVIDIA announcement, with Canaccord Genuity reiterating a Buy rating, indicating confidence in the company's growth potential [2] - The stock experienced a slight decrease of approximately 0.25% to $234.87, with fluctuations between a low of $231.08 and a high of $237.74 on the same day [3] - Over the past year, Natera's stock reached a high of $256.36 and a low of $125.38, showcasing significant volatility and growth potential [3] Market Position - Natera's market capitalization is approximately $32.42 billion, indicating a substantial presence in the healthcare sector [4] - The trading volume for the day was 574,776 shares on the NASDAQ exchange, reflecting active investor interest [4] - The collaboration with NVIDIA is expected to bolster Natera's position in the precision medicine market, driving advancements in AI model development and application [4]

Core Insights - Natera (NTRA) has partnered with NVIDIA (NVDA) to accelerate the development of a multimodal AI foundation model platform aimed at enhancing precision care [1][7] - The collaboration will leverage Natera's extensive longitudinal datasets and machine learning models alongside NVIDIA's advanced computing technology to improve medical data analysis [2][3] Company Developments - The partnership aims to create advanced computational systems for training large-scale AI models, which will facilitate more accurate diagnoses and personalized treatment decisions [2][5] - Natera's AI solutions utilize one of the largest cancer datasets globally, with its NeoSelect system outperforming 25 existing neoantigen prediction methods [8] - The collaboration is expected to enhance Natera's competitive advantage by improving its AI and data capabilities, leading to new revenue streams and stronger relationships with biopharma partners [5] Financial Performance - Following the announcement of the collaboration, Natera's stock increased by 0.5%, with a notable 48.9% rise over the past six months, significantly outperforming the industry and S&P 500 [4] Industry Outlook - The AI in oncology market is projected to reach $2.40 billion by 2026, with a compound annual growth rate (CAGR) of 27.6% through 2035, driven by technological advancements and increasing cancer cases [11]

Core Insights - Johnson & Johnson is presenting 11 abstracts at the 64th Annual Meeting of the American College of Neuropsychopharmacology, focusing on advancements in neuropsychiatry, particularly in major depressive disorder (MDD) and treatment-resistant depression (TRD) [1][2] Group 1: Research Presentations - Key presentations include analyses of CAPLYTA (lumateperone) for remission in MDD, metabolic profiles of seltorexant versus quetiapine XR in MDD with insomnia, and effects of SPRAVATO (esketamine) on anhedonia in TRD [3][4] - Specific posters will cover the efficacy of lumateperone in various demographic and clinical subgroups, as well as treatment-emergent adverse events in MDD patients [3][4] Group 2: Company Commitment - Johnson & Johnson emphasizes its commitment to addressing unmet needs in depression, schizophrenia, and bipolar disorder, aiming for disease remission through innovative research and clinical findings [2] - The company is advancing its portfolio with a focus on novel mechanisms and AI-driven precision tools to redefine standards of care in neuropsychiatry [2] Group 3: Major Depressive Disorder (MDD) Insights - MDD affects approximately 332 million people globally, representing about 4% of the population, with around 22 million adults in the U.S. experiencing at least one major depressive episode in 2023 [6] - The disorder is complex and heterogeneous, with responses to treatment varying widely, highlighting the need for personalized approaches [6][7] - Approximately 60% of MDD patients experience insomnia symptoms, which significantly impact their quality of life and increase the risk of depressive relapse [7] Group 4: Treatment-Resistant Depression (TRD) Insights - About one-third of adults with MDD are classified as having TRD, defined as inadequate response to two or more oral antidepressants [8] - TRD poses a significant economic burden and affects patients' lives severely, with a high percentage not achieving remission even after multiple treatment attempts [8]

Core Insights - Anavex Life Sciences Corp. is participating in ACCESS-AD, a European initiative aimed at enhancing the adoption of innovative diagnostic and therapeutic approaches for Alzheimer's disease over a five-year period, funded by the European Commission's Innovative Health Initiative [1][2] Group 1: Alzheimer's Disease Management - ACCESS-AD is launched at a critical time as the prevalence of Alzheimer's disease in Europe is projected to exceed 19 million by 2050, highlighting the urgent need for scalable and accessible therapeutic options [2] - Recent approvals of antibody-based disease-modifying therapies (DMTs) have expanded treatment options, but health systems still face significant challenges in diagnosis, patient stratification, imaging capacity, and ongoing monitoring [2] Group 2: Precision Medicine and Blarcamesine - Blarcamesine, an investigational small-molecule therapy, will be evaluated within ACCESS-AD to target autophagy through SIGMAR1 activation, aiming to restore cellular function and slow neurodegenerative processes in Alzheimer's disease [3][5] - The integration of blarcamesine into ACCESS-AD's framework will facilitate the generation of predictive clinical insights using harmonized imaging, biomarker, and digital datasets [5] Group 3: Clinical Framework and Innovation - ACCESS-AD is establishing a coordinated clinical framework that incorporates advanced neuroimaging, blood-based biomarkers, digital measures, and AI-driven decision support to streamline patient pathways across Europe [4] - The initiative aims to support early detection, personalized treatment choices, and the safe implementation of emerging therapies [4] Group 4: Company Overview - Anavex Life Sciences Corp. is focused on developing novel therapeutics for neurodegenerative, neurodevelopmental, and neuropsychiatric disorders, including Alzheimer's disease, with its lead drug candidate, ANAVEX2-73 (blarcamesine), having completed multiple clinical trials [9] - The company is committed to precision medicine approaches that incorporate clinical data, genomic markers, and digital endpoints to enhance treatment efficacy [5][9]

January 2026 Improving Lives Through Transformative Precision Medicines JPM 2026 | 44th Annual Healthcare Conference NASDAQ: IDYA Safe Harbor Statement Certain statements in this presentation and the accompanying oral commentary are forward-looking statements. These statements relate to future events or the future financial performance of IDEAYA Biosciences, Inc. (the "Company") and involve known and unknown risks, uncertainties and other factors that may cause the actual results, levels of activity, perfor ...

Company Overview - Tempus aims to unlock precision medicine through AI-enabled diagnostics[6] - The company's platform connects to over 5,000 providers across the US[10] - Tempus leverages a large proprietary healthcare dataset of over 45 million patient records[13] Diagnostics Business - The Diagnostics business delivered approximately 800,000 clinical tests in 2025[30] - The Diagnostics business experienced a unit growth rate of approximately 28% in Q4 2025[30] - Oncology ASP is expected to rise by over $500 in the next several years due to reimbursement tailwinds[31] Data & Applications Business - Data and Applications revenue reached approximately $316 million in 2025, representing approximately 31% growth[38] - The Data & Applications business has signed over $2 billion in contracts to date[38] - The Total Remaining Contract Value (TCV) for Data & Applications is over $1.1 billion as of year-end 2025[39] - The Data Licensing Retention rate is approximately 126% as of year-end 2025[39] Financial Outlook - The company anticipates revenue of approximately $1.27 billion for 2025, reflecting approximately 83% year-over-year growth[63] - The company projects revenue growth of approximately 25% year-over-year in 2026, reaching approximately $1.59 billion[65]

Company Overview - Caris Life Sciences has a comprehensive oncology database with over 1,016,000 molecular profiles[5] - The company has a global presence with over 1,800 employees[7] - Caris has established a Precision Oncology Alliance (POA) with 99 leading cancer centers[5] Data and Technology - The company has profiled over 1 million cases in its genomic dataset[9] - Caris possesses over 627,000 whole exomes and 678,000 whole transcriptomes[9, 11] - The company has access to over 740,000 profiles with matched molecular data and clinical outcomes[11] Market Trends and Reach - Cancer centers are standardizing molecular profiling towards technology and service leaders[13] - Caris has a field-based team of approximately 250 and 50 MSLs serving over 6,000 oncologists in the US[18] - The company has integrated ordering locations in over 3,350 EHRs[18] Financial Performance - Caris achieved $281 million in revenue in Q4 2025, representing a 116% year-over-year growth[35, 67] - The company's total revenue increased to $800 million in FY 2025, a 94% increase year-over-year[69] - Molecular profiling services revenue increased to $755 million, a 116% increase year-over-year[69]

This presentation should be read together with our risk factors, as disclosed in our most recently filed reports with the Australian Securities Exchange (ASX), U.S. Securities and Exchange Commission (SEC), including our Annual Report on Form 20-F filed with the SEC, or on our website. The information contained in this presentation is not intended to be an offer for subscription, invitation or recommendation with respect to shares of Telix Pharmaceuticals Limited (Telix) in any jurisdiction, including the U ...

Lumexa Imaging FY Conference Summary Company Overview - **Company Name**: Lumexa Imaging (NasdaqGS:LMRI) - **Industry**: Diagnostic Imaging - **Market Size**: $140 billion Total Addressable Market (TAM) growing at a 4% CAGR; Outpatient sector at $33 billion TAM growing at a 7% CAGR [7][22] Key Points Industry Dynamics - Diagnostic imaging is a dynamic industry driven by an aging population and advancements in treatment paradigms requiring advanced imaging technologies such as MRI, CT, and PET scans [7][22] - The outpatient imaging sector is experiencing significant growth, with a shift towards lower-cost service centers [22][18] Company Positioning - Lumexa Imaging is the second largest platform in the outpatient imaging space with 188 sites across 13 states, focusing on high-growth markets [7][8] - The company operates a scalable model with a strong joint venture partnership strategy, having completed 44 de novos since inception, including a record nine in the past year [9][12] Financial Metrics - Advanced imaging accounts for 63% of revenue and 36% of volume, indicating a premium revenue model [13][27] - The company has a 97% patient satisfaction rate and an NPS of 91, significantly higher than industry benchmarks [12][15] - Revenue from outpatient imaging centers constitutes over 80% of total revenue and EBITDA [10][12] Growth Strategy - Lumexa aims to continue expanding through de novos and acquisitions, targeting 8-10 new centers annually [9][50] - The company emphasizes same-store growth by maximizing schedules and building referral relationships [48][49] - There is a focus on leveraging advanced technology, including AI, to enhance operational efficiency and patient care [10][33] Joint Venture Model - The joint venture model with health systems allows for shared capital expenditures and operational efficiencies, differentiating Lumexa from competitors [51][52] - The company has identified over 100 potential health system partners across top markets, many of whom currently lack imaging partnerships [43] Labor Market and Staffing - Lumexa benefits from a favorable labor market for radiologists and technologists, with better retention rates than industry averages [53] - The company provides flexibility and job satisfaction for staff, contributing to lower turnover [53] Future Outlook - The company is focused on maintaining a strong balance sheet while pursuing growth opportunities, with a commitment to transparency and communication with stakeholders [49][56] - Investors are expected to appreciate the consistency and quality of Lumexa's growth as it continues to establish itself as a leading outpatient imaging provider [55] Additional Insights - The outpatient imaging industry remains highly fragmented, with Lumexa and its largest competitor, RadNet, accounting for less than 10% of the market [25] - The company’s operational model allows for quick scalability and adaptability in response to market demands [30][41] - Lumexa's strategic partnerships and technology investments are designed to enhance patient experience and operational efficiency, positioning the company for sustained growth [34][36]