人 - 动物嵌合体

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猪胚胎中培育的人类心脏,存活了21天
Hu Xiu· 2025-06-24 06:30
Core Insights - Researchers have successfully cultivated human heart cells within pig embryos, marking a significant advancement in the field of organ transplantation and regenerative medicine [1][2][4] Group 1: Research Findings - The embryos containing human cells survived for 21 days, during which the small hearts began to beat [1][4] - The research involved reprogramming human stem cells to enhance their survival in pig embryos by introducing genes that prevent cell death and promote growth [3][4] - The team previously succeeded in cultivating early human kidneys in pig embryos, which survived for a month, and aimed to achieve similar results with the heart [2][3] Group 2: Methodology - Specific genes essential for heart development were knocked out in the pig embryos, allowing human stem cells to be injected during the early embryonic stage [3][4] - The human cells were marked with fluorescent biological markers to identify them within the developing heart [4][5] Group 3: Future Implications - The research could potentially address the global shortage of transplantable organs by creating animal models that can grow human organs [2][6] - There is a need for further analysis to confirm the composition of the heart cells, as complete human cell integration is crucial for successful transplantation [6][7]