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磁光“利器”直击生物检测三大痛点——记山东省自然科学二等奖光/磁异质纳米材料的精准合成及传感研究
Zhong Guo Hua Gong Bao· 2025-08-11 03:22
Core Insights - The project "Precise Synthesis and Sensing Research of Optical/Magnetic Heterogeneous Nanomaterials" has won the 2024 Shandong Provincial Natural Science Second Prize, marking significant advancements in the synthesis methods and sensing applications of optical/magnetic heterogeneous nanomaterials [1] Group 1: Environmental Monitoring and Biological Detection - Traditional detection methods face challenges such as sample loss during pathogen detection, difficulty in distinguishing between TNP and TNT, and insufficient sensitivity in real-time monitoring of toxic gases [1] - The research team has focused on the precise synthesis methodology of optical/magnetic heterogeneous nanomaterials over seven years, establishing innovative methods for integrated separation, enrichment, and sensing [1] Group 2: Innovations in Pathogen Detection - A new approach combining magnetic enrichment and optical detection has been developed, leading to the creation of controllable magnetic/plasmonic dumbbell-type nanomaterials, which integrate both functions into a single nanoparticle [2] - This technology has been successfully applied in companies like Qingdao Jianma Gene Technology Co., Ltd., helping them achieve EU CE certification and national Class III medical device certification, generating economic benefits of approximately 155.79 million yuan [2] Group 3: Explosive Detection Technology - The team has developed a method combining chemical oxidation and liquid-phase exfoliation to create high quantum yield nitrogen-doped graphene quantum dots, addressing the challenge of distinguishing TNP from TNT [2] - The developed label-free fluorescence sensing method has a detection limit for TNP as low as 8.2 nanometers, demonstrating high selectivity without interference from other nitro explosives and metal ions [2] Group 4: Toxic Gas Detection Enhancements - A new strategy of "lattice mismatch" epitaxial growth has been proposed, resulting in heterogeneous nanoprobes with excellent plasmonic properties [3] - The team has innovatively embedded inorganic nanoprobes in agarose, developing a high-performance colorimetric sensing method for real-time monitoring of toxic gases, achieving a sensitivity for hydrogen sulfide detection that is 120 times greater than traditional lead acetate test strips [3] Group 5: Research Output and Intellectual Property - The research team has published five papers in international authoritative journals and written three reviews, with five national invention patents granted for their technology [4]
磁光“利器”直击生物检测三大痛点——记山东省自然科学二等奖光/磁异质纳米材料的精准合成及传感研究   
Zhong Guo Hua Gong Bao· 2025-08-11 03:17
Core Insights - The project "Precise Synthesis and Sensing Research of Optical/Magnetic Heterogeneous Nanomaterials," completed by China University of Petroleum (East China) and Xiamen University, won the 2024 Shandong Provincial Natural Science Second Prize, marking significant advancements in the synthesis methods and sensing applications of optical/magnetic heterogeneous nanomaterials [1] Group 1: Environmental Monitoring and Biological Detection - Traditional detection methods face challenges such as sample loss during pathogen detection, difficulty in distinguishing between TNP and TNT in nitro explosives, and insufficient sensitivity in real-time monitoring of toxic gases [1] - The project team focused on the precise synthesis methodology of optical/magnetic heterogeneous nanomaterials over seven years, establishing innovative methods for integrated separation, enrichment, and sensing [1] Group 2: Innovations in Pathogen Detection - The team proposed a new approach combining magnetic enrichment and optical detection, developing a synthesis strategy called "in-situ nucleation—Austrian maturation—directional growth," resulting in controllable magnetic/plasmonic dumbbell-shaped nanomaterials [2] - This technology has been applied in companies like Qingdao Jianma Gene Technology Co., Ltd., helping them achieve EU CE certification and national Class III medical device certification, generating economic benefits of 155.79 million yuan [2] Group 3: Explosive Detection Technology - To address the challenge of distinguishing TNP from TNT, the team developed a technique combining chemical oxidation and liquid-phase exfoliation, producing high quantum yield nitrogen-doped graphene quantum dots [2] - The developed label-free fluorescence sensing method has a detection limit for TNP as low as 8.2 nanometers, demonstrating high selectivity unaffected by other nitro explosives and metal ions [2] Group 4: Toxic Gas Detection Enhancements - The team introduced a new strategy of "lattice mismatch" epitaxial growth, creating heterogeneous nanoprobes with excellent plasmonic properties, elucidating the growth mechanism of heterogeneous metal atom islands [3] - They innovatively embedded inorganic nanoprobes in agarose, developing a high-performance colorimetric sensing method for real-time monitoring of toxic gases such as hydrogen sulfide, formaldehyde, and cyanide [3] - The sensitivity of the hydrogen sulfide detection test strip is 120 times greater than that of traditional lead acetate test strips, capable of producing visible color responses within one minute at 50 ppm [3] Group 5: Research Output - The research team has published five papers in international authoritative journals and authored three reviews, with five national invention patents granted for their technology [4]