Core Viewpoint - The Chinese Academy of Sciences has developed the world's first high temporal and spatial resolution Brillouin microscope, significantly enhancing imaging speed and providing a crucial tool for mechanical research in life sciences [1][2]. Group 1: Technological Advancements - The new Brillouin microscope achieves sub-millisecond temporal resolution and sub-micron spatial resolution, marking a two-order-of-magnitude increase in imaging speed while maintaining excellent imaging quality and spectral specificity [1]. - The system utilizes a 780-nanometer wavelength and a peak power of 267 watts, achieving over 31 decibels of noise suppression through a high noise-reduction self-balancing detection scheme [1]. Group 2: Applications and Validation - The performance of the enhanced Brillouin microscope has been validated on various biological samples, including single cells, organoids, zebrafish embryos, and follicles [2]. - The research team observed dual Brillouin peaks in zebrafish embryos, revealing mechanical differences in heterogeneous extracellular matrices and cavities, and captured dynamic mechanical changes during early cell division in Caenorhabditis elegans embryos [2]. Group 3: Future Implications - This breakthrough addresses the technical bottlenecks of traditional Brillouin microscopy in terms of imaging speed and sensitivity, showcasing significant performance advantages across multiple biological models [2]. - The enhanced system is expected to become a new tool for revealing the mechanisms of life mechanics, exploring disease occurrence, and studying tissue and organ development, thus expanding the application of Brillouin microscopy in both basic research and clinical settings [2].