Core Viewpoint - The development of a programmable magnetic field-driven bio-inspired hydrogel fiber robot offers a novel, non-invasive, and precise method for targeted drug delivery in the treatment of intracranial tumors, particularly those located near critical brain areas [1][5]. Group 1: Technology and Innovation - The research team has created a hydrogel fiber robot inspired by the movement of nematodes, capable of multi-modal movement in the narrow subarachnoid space of the brain [2][3]. - The hydrogel fiber robot is made from a mixture of the animal's own blood and magnetic particles, ensuring biocompatibility and flexibility, which allows it to navigate through tight spaces without causing damage to surrounding tissues [2][3]. - The robot can perform various movements such as swinging, crawling, and rolling, controlled by an external programmable magnetic field [3]. Group 2: Drug Delivery Mechanism - The robot utilizes a high-frequency alternating magnetic field to induce fragmentation for drug release, allowing for targeted delivery of chemotherapy drugs like doxorubicin [4]. - The drug delivery mechanism is designed to be responsive to magnetic field parameters, enabling precise control over the drug release rate, thus avoiding the toxicity associated with traditional chemical triggers [4][5]. Group 3: Clinical Application and Efficacy - In a study involving 18 miniature pigs with glioma models, the treatment group using the drug-loaded hydrogel fiber robot showed a tumor size reduction of four times compared to the control group after 26 days [5]. - The hydrogel fiber robot is customized from the patient's own blood, minimizing immune rejection and allowing for automatic degradation post-treatment, eliminating the need for surgical removal [5]. - The innovative combination of bio-inspired movement, real-time X-ray imaging, and magnetic-responsive drug release presents a transformative approach for non-invasive treatment of deep-seated brain tumors [5].