Core Viewpoint - The article discusses a breakthrough in rapid diagnosis of neuroendocrine tumors using a novel platform called CIOC-DCS-mini MS, which integrates carboxylate ion organic crystal functionalized paper with direct capillary spray mini mass spectrometry, enabling high-sensitivity and high-selectivity analysis without the need for chromatographic separation [1][2]. Innovation in Technology - The research team has developed a unique CIOC enrichment material that captures monoamine neurotransmitters through electrostatic and hydrogen bonding interactions, effectively removing matrix interference [3]. - An integrated "sampling-enrichment-detection" process has been created, allowing the functionalized paper strip to directly extract target substances from samples, significantly enhancing detection efficiency by eliminating complex sample preparation and chromatographic steps [3]. Performance Advantages - The platform shows significant performance improvements, with signal enhancement of 3.4 to 10.9 times in plasma and urine samples compared to unmodified paper, greatly improving the signal-to-noise ratio [4]. - Sensitivity reaches the ng level, with a linear range of 0–500 ng/mL (R² > 0.9981) and a limit of detection (LOD) as low as 0.51–2.11 ng/mL in urine samples, meeting the requirements for trace biomarker detection [5]. - The entire analysis process takes approximately 3 minutes from sample addition to mass spectrometry results, aligning with the rapid diagnostic needs of point-of-care testing (POCT) [6]. Application Prospects - The platform has been successfully used for direct detection of clinical anonymous plasma and urine samples, demonstrating its capability in real complex samples [7]. - The innovation not only miniaturizes mass spectrometry but also integrates advanced functional materials, overcoming key bottlenecks in direct analysis of complex biological samples, thus paving the way for mass spectrometry technology to transition from laboratory settings to clinical and field applications [7].