Core Viewpoint - The research team from the Chinese Academy of Agricultural Sciences has developed a novel multifunctional nanogel that combines natural bee products with advanced materials, providing an antibiotic-free and effective solution for chronic wound management, published in the Chemical Engineering Journal on July 8, 2025 [1][8]. Group 1: Research and Development - The innovative team focused on the interdisciplinary integration of "natural bee products + advanced materials" to address the rising global issue of bacterial resistance and chronic wound healing [1]. - The new nanogel exhibits multiple functions, including antibacterial, anti-inflammatory, antioxidant, and wound healing properties, paving a new path for functional medical materials based on bee products [1][4]. Group 2: Composition and Mechanism - The active ingredient, 10-hydroxy-2-decenoic acid (10-HDA), is a key molecule in royal jelly, known for its therapeutic properties, but its hydrophobic nature limits its bioavailability [3]. - To enhance the stability and release efficiency of 10-HDA, the team employed a "nano-delivery + sustained release" strategy, utilizing carbon dots (CDs) as carriers to improve the bioactivity of 10-HDA [3][4]. Group 3: Performance and Efficacy - The developed 10-HDA@CDs@HON/SA-DA multifunctional hydrogel demonstrated significant healing effects in a mouse model of Staphylococcus aureus infection, accelerating wound closure and improving healing quality [6]. - The hydrogel promotes angiogenesis, fibroblast activity, and reduces inflammation, while also restoring the balance of epidermal keratinocyte subpopulations and activating key regeneration signaling pathways [6][8].