REHOVOT, Israel, Oct. 16, 2025 /PRNewswire/ -- CollPlant Biotechnologies (NASDAQ: CLGN), a regenerative and aesthetic medicine company developing disruptive technologies and products based on its proprietary, non-animal recombinant human collagen (rhCollagen), today announced that, according to a scientific article published in the Archives of Dermatological Research, researchers from Mayo Clinic have developed the first fully humanized 3D bioprinted skin model using CollPlant's plant-derived rhCollagen. Th ...

Company Overview - CollPlant Biotechnologies is a regenerative and aesthetic medicine company focused on developing technologies and products based on non-animal-derived recombinant human collagen (rhCollagen) [1][5] - The company aims to innovate in the fields of tissue repair, medical aesthetics, and organ manufacturing through its proprietary plant-based genetic engineering technology [5] Conference Participation - CollPlant will participate in the International Conference on Biofabrication 2025, scheduled for September 14–17, 2025, in Warsaw, Poland [1] - The company will have two presentations during the conference, showcasing its rhCollagen platform and biofabrication applications [2][7] Biofabrication and 3D Bioprinting - The conference will focus on advancements in biofabrication and bioprinting, which are crucial for medical research and the fabrication of complex scaffolds for tissue and organ engineering [2][4] - CollPlant's rhCollagen-based bioinks are highlighted for their controlled rheology, non-animal safety profile, biocompatibility, and tunable mechanical properties, making them suitable for high-fidelity 3D bioprinting [2] International Society for Biofabrication - The International Society for Biofabrication (ISBF) is a non-profit organization that promotes research and development in biofabrication, including 3D printing of tissues and regenerative medicine [3] - The ISBF organizes the annual International Conference on Biofabrication, which has grown to attract over 500 participants from various countries since its inception in 2006 [4]

Core Insights - CollPlant Biotechnologies is advancing its photocurable dermal filler program and has made significant progress in preclinical testing, preparing for clinical trials [3][4][5] - The company raised $3.6 million in a registered direct offering in the second quarter of 2025, providing financial flexibility for ongoing initiatives [17][19] - CollPlant's regenerative breast implant program aims to address a multi-billion-dollar market, focusing on safety and durability compared to existing solutions [8][10][12] Financial Performance - GAAP revenues for Q2 2025 were $179,000, a decrease from $249,000 in Q2 2024, primarily due to reduced sales of rhCollagen-based products [21] - For the first half of 2025, GAAP revenues increased to $2.2 million from $347,000 in the same period of 2024, largely due to a $2 million milestone payment from AbbVie [22][23] - GAAP net loss for Q2 2025 was $3.3 million, or $0.28 per share, an improvement from a net loss of $4.2 million, or $0.37 per share, in Q2 2024 [31] Product Development and Collaborations - The photocurable dermal filler is designed for superior skin lifting and rejuvenation, generating interest from leading medical aesthetics companies [3][4] - CollPlant has a collaboration with AbbVie, which includes a worldwide exclusive license for combining rhCollagen technology with AbbVie's products for dermal fillers [6][7] - The company is also expanding its international distribution network for its Vergenix™ STR tendon-repair product, which has received CE Mark approval and is marketed primarily in Europe [13][15] Market Position and Strategy - CollPlant's regenerative breast implants are positioned to be first-to-market with a solution that promotes natural tissue regeneration and avoids immune rejection [10][12] - The company is focusing on non-animal-derived collagen solutions, aligning with industry trends towards more sustainable and ethical medical products [20] - The appointment of a new Vice President for Commercial North America aims to enhance the company's market presence and commercial strategy in key regions [19]

Company Overview - CollPlant Biotechnologies is a regenerative and aesthetic medicine company focused on 3D bioprinting of tissues and organs, tissue repair, and medical aesthetics [2] - The company's products are based on rhCollagen (recombinant human collagen) produced using proprietary plant-based genetic engineering technology [2] Recent Developments - CollPlant will report its financial results for the second quarter on August 20, 2025, before the opening of U.S. financial markets [1] - In 2021, CollPlant entered into a development and global commercialization agreement for dermal and soft tissue fillers with Allergan, a leader in the dermal filler market [3]

Core Insights - 3D Systems has achieved FDA approval for a 3D bioprinting solution for the regenerative repair of peripheral nerve damage, in collaboration with TISSIUM [1][4] - The newly developed device, COAPTIUM® CONNECT with TISSIUM Light, is a bioabsorbable, atraumatic, and sutureless solution for nerve repair, marking a significant milestone in the industry [1][4] - The global 3D bioprinting market is projected to grow from $1.3 billion in 2024 to $2.4 billion by 2029, indicating strong growth potential for the sector [3] Company Developments - 3D Systems has been a leader in bioprinting for nearly a decade, focusing on developing technologies for regenerative medicine and personalized healthcare [2][3] - The company has collaborated with United Therapeutics Corporation since 2017 to create an unlimited supply of human lungs for transplantation, showcasing its commitment to advancing medical solutions [2][3] - 3D Systems has produced over two million implants and instruments for more than 100 CE-marked and FDA-cleared devices, demonstrating its extensive experience in the medical device sector [3] Industry Impact - The collaboration with TISSIUM sets a new standard for high-resolution elastomeric 3D-printed medical implants, enhancing the capabilities of bioprinting technologies [4] - 3D Systems' innovations in bioprinting are expected to transform patient care by enabling the fabrication of living tissues and developing new therapeutics [5] - The advancements in 3D bioprinting are anticipated to accelerate the adoption of additive manufacturing in the medical field, contributing to improved healthcare delivery [4][5]

Core Insights - CollPlant Biotechnologies has received a patent approval from the European Patent and Trademark Office for its injectable fillers and regenerative breast implant candidates, which are aimed at the aesthetic and reconstructive markets [1][3]. Group 1: Company Developments - The newly allowed patent application covers CollPlant's injectable soft tissue fillers and organ manufacturing technology related to its regenerative breast implant pipeline [2]. - The patent is effective until 2041 and is a key part of the company's strategy to expand its rhCollagen technology into high-value markets [3]. - CollPlant is focusing on building protection around its proprietary technology, enhancing its competitiveness in the aesthetic and reconstructive markets [3]. Group 2: Market Potential - The market for injectable soft-tissue fillers is currently estimated to exceed $6 billion, while the addressable market for breast implants is over $3 billion [3]. - The soft tissue fillers market is projected to grow at a rate of 10%, reaching an estimated $6.3 billion annually [5]. - The regenerative breast implants are designed to regenerate natural breast tissue without triggering an immune response, addressing a significant unmet need in the market [6][7]. Group 3: Product Innovations - CollPlant is developing a photocurable regenerative dermal filler that combines rhCollagen with other substances, intended to provide lifting, sculpturing, and tissue regeneration effects [4]. - The photocurable filler is designed to be injected in a semi-liquid phase and hardens post-injection through light illumination, simplifying the injection process [5].

REHOVOT, Israel, May 30, 2025 /PRNewswire/ -- CollPlant Biotechnologies (NASDAQ: CLGN), a regenerative and aesthetics medicine company developing innovative technologies and products based on its non-animal-derived, rhCollagen for tissue regeneration and medical aesthetics, today announced that it has entered into a definitive agreement for the issuance and sale of an aggregate of 1,200,002 of the Company's ordinary shares at a purchase price of $3.00 per share in a registered direct offering priced at-the- ...

- In Q1 following a development achievement, CollPlant received a $2 million payment from AbbVie – Collaboration Updates AbbVie Collaboration In February 2025, following a key development milestone, CollPlant received a $2 million milestone payment from its partner, AbbVie, pursuant to the existing development and commercialization agreement. Under this agreement, CollPlant granted AbbVie a worldwide exclusive license to use its recombinant human collagen (rhCollagen) technology in combination with AbbVie's ...