Group 1: Amazon - Amazon is considered a key stock in a long-term investment portfolio due to its "Day 1" culture that fosters continuous innovation and opportunity exploration [3][4] - Amazon Web Services (AWS) generated $93 billion in sales during the first nine months of 2025, accounting for 59% of Amazon's total operating income [4] - Future opportunities for Amazon include launching a satellite internet service and entering the consumer robotics market [6] Group 2: Apple - Apple is the largest individual stock holding in the portfolio, with a strong ecosystem centered around the iPhone [6][7] - The company is expected to excel in the AI glasses market and generate significant revenue from the rollout of 6G wireless networks in the next decade [8] Group 3: Berkshire Hathaway - Berkshire Hathaway remains a strong investment choice due to its diversified portfolio and the continuation of Warren Buffett's business philosophy under new CEO Greg Abel [9][10][12] - The company's market cap is $1.1 trillion, with a gross margin of 24.85% [11][12] Group 4: Intuitive Surgical - Intuitive Surgical is positioned to benefit from the aging global population and the increasing volume of surgical procedures [13] - The company estimates that around 8 million procedures are currently candidates for its surgical robots, with potential growth to 22 million as technology advances [14] Group 5: Vertex Pharmaceuticals - Vertex Pharmaceuticals holds a monopoly in treating cystic fibrosis and has expanded its portfolio with new therapies [15][16] - The company is expected to gain regulatory approval for treatments targeting IgA nephropathy, which affects 330,000 patients in the U.S. and Europe [18][19]