Core Points - NuCana plc will change the ratio of its American Depository Shares (ADSs) from one ADS representing twenty-five ordinary shares to one ADS representing five thousand ordinary shares, effective August 11, 2025 [1][2] - This change is equivalent to a one-for-two hundred reverse ADS split and aims to support liquidity and regain compliance with Nasdaq's minimum bid price requirement [2][3] - The exchange will occur automatically for holders of uncertificated ADSs, while certificated holders must surrender their ADSs for cancellation [2] - The change will not affect shareholders' proportional equity interests, except for fractional ADSs, which will be aggregated and sold [2] - The trading price of ADSs is expected to increase proportionally, although no assurance can be given regarding the actual trading price post-change [3] Company Overview - NuCana is a clinical-stage biopharmaceutical company focused on improving cancer treatment outcomes through its ProTide technology [4] - The company is developing new medicines, ProTides, to enhance the efficacy and safety of conventional chemotherapy agents [4] - NuCana's pipeline includes NUC-7738, currently in Phase 2 studies for advanced solid tumors, and NUC-3373, being evaluated in a Phase 1b/2 study for advanced solid tumors and lung cancer [4]

Core Viewpoint - NaaS Technology Inc. is changing the ratio of its American Depositary Shares (ADSs) to Class A ordinary shares from 1:200 to 1:800, effective April 28, 2025, which is equivalent to a one-for-four reverse ADS split [1][2]. Company Overview - NaaS Technology Inc. is the first U.S.-listed EV charging service company in China and a subsidiary of Newlinks Technology Limited, a leading energy digitalization group in China [4]. - The company provides new energy asset operation services and utilizes advanced technology to match charging supply with demand, enhancing the charging experience for electric vehicle users [4]. Impact of ADS Ratio Change - The change in the ADS Ratio is expected to increase the ADS trading price proportionally, although there is no assurance that the price will be four times greater than before the change [3]. - Existing ADS holders will need to surrender four current ADSs for one new ADS, with fractional entitlements aggregated and sold by the depositary bank [2]. - The change will not affect the underlying Class A ordinary shares, and no shares will be issued or cancelled in connection with the change [2].