Core Insights - Esperion Therapeutics is a commercial stage biopharmaceutical company focused on developing new medicines for unmet patient needs, particularly in cardiovascular disease [2][3] - The company has developed the only FDA-approved oral, once-daily, non-statin medications for patients with elevated LDL-C levels [2] - Esperion is advancing its next-generation program targeting ATP citrate lyase inhibitors (ACLYi), leveraging new insights for rational drug design [2] Company Developments - Esperion will present at the Piper Sandler 37th Annual Healthcare Conference on December 3, 2025, at 3:30 p.m. ET [1] - The company continues to evolve through commercial execution, international partnerships, and advancements in its pre-clinical pipeline [3] Contact Information - Investor relations contact: Alina Venezia, email: investorrelations@esperion.com, phone: (734) 887-3903 [4] - Media contact: Tiffany Aldrich, email: corporateteam@esperion.com, phone: (616) 443-8438 [4]

Core Insights - Esperion's partner HLS Therapeutics has received approval from Health Canada to market NILEMDO for LDL-Cholesterol reduction in Canadians at risk of cardiovascular disease, with a commercial launch expected in Q2 2026 [1][2]. Company Overview - Esperion Therapeutics is a biopharmaceutical company focused on developing and commercializing innovative therapies for patients with elevated LDL-C and cardiovascular disease risk, including the only FDA-approved oral, once-daily, non-statin medications [4]. - The company is advancing its next-generation program aimed at developing ATP citrate lyase inhibitors (ACLYi), leveraging new insights for rational drug design [4]. Market Context - Approximately 2.6 million Canadian adults are diagnosed with heart disease, making it the second leading cause of death in Canada, with 14 adults dying every hour due to this condition [3].

Core Insights - Esperion has appointed John Harlow as Chief Commercial Officer, effective November 17, 2025, to enhance sales and marketing performance during a critical growth phase for the company [1][2] Company Overview - Esperion Therapeutics is a commercial stage biopharmaceutical company focused on developing and marketing innovative medicines for patients at risk of cardiovascular disease, specifically targeting elevated low-density lipoprotein cholesterol (LDL-C) [5] - The company has developed the only FDA-approved oral, once-daily, non-statin medications for this patient group, supported by the CLEAR Cardiovascular Outcomes Trial involving nearly 14,000 patients [5] Leadership Appointment - John Harlow brings over two decades of senior leadership experience in the pharmaceutical industry, having previously served as Chief Commercial Officer at Melinta Therapeutics, where he nearly doubled revenue with an 85% growth in 2024 compared to 2020 [2] - Harlow's extensive background includes roles at Baudax Bio, Recro Pharma, Endo Pharmaceuticals, Shionogi USA, Pfizer, Alpharma, and Novartis, as well as experience as an equity research analyst at Bank of America Merrill Lynch [2] Strategic Goals - Harlow's leadership is expected to drive the expansion of Esperion's product adoption in the U.S. and enhance its global presence, particularly in delivering cardiovascular risk reduction therapies [2][4] - The company aims to leverage Harlow's expertise to accelerate growth and improve access to its therapies, NEXLETOL and NEXLIZET, which are designed to manage cardiovascular risk [4]

Core Insights - Esperion will report its third quarter 2025 financial results on November 6, 2025, before market opens, followed by a management webcast at 8:00 a.m. ET to discuss the results and provide business updates [1][2] Company Overview - Esperion Therapeutics, Inc. is a commercial stage biopharmaceutical company focused on developing new medicines for unmet patient needs, particularly in cardiovascular disease [3] - The company has developed the only FDA-approved oral, once-daily, non-statin medications for patients at risk for cardiovascular disease with elevated LDL-C levels, supported by the CLEAR Cardiovascular Outcomes Trial involving nearly 14,000 patients [3] - Esperion is advancing its next-generation program focused on ATP citrate lyase inhibitors (ACLYi), leveraging new insights for rational drug design to create potent and specific inhibitors [3][4] Business Development - Esperion is evolving into a leading global biopharmaceutical company through effective commercial execution, international partnerships, collaborations, and the advancement of its pre-clinical pipeline [4]

Core Viewpoint - Esperion Therapeutics, Inc. has announced a public offering of 30 million shares at a price of $2.50 per share, aiming to raise approximately $75 million before expenses [1]. Group 1: Offering Details - The offering includes a 30-day option for underwriters to purchase an additional 4.5 million shares [1]. - The offering is expected to close on or about October 9, 2025, pending customary closing conditions [1]. - The shares are being offered under an effective shelf registration statement filed with the SEC on April 18, 2025 [3]. Group 2: Management and Coordination - Piper Sandler & Co. and Cantor Fitzgerald & Co. are acting as joint book-running managers for the offering [2]. - Citizens JMP Securities, LLC, H.C. Wainwright & Co., LLC, and Needham & Company, LLC are co-managers for the offering [2]. Group 3: Company Overview - Esperion is a biopharmaceutical company focused on developing oral, once-daily, non-statin medicines for patients with elevated LDL-C [6]. - The company has FDA-approved medications supported by the CLEAR Cardiovascular Outcomes Trial involving nearly 14,000 patients [6]. - Esperion is advancing its pipeline with a focus on developing ATP citrate lyase inhibitors (ACLYi) [6][7].

Core Viewpoint - Esperion Therapeutics, Inc. has initiated an underwritten public offering of its common stock, with a potential additional 15% of shares available for underwriters [1][2] Company Overview - Esperion is a commercial stage biopharmaceutical company focused on developing and commercializing oral, once-daily, non-statin medicines for patients with elevated low-density lipoprotein cholesterol (LDL-C) [1][6] - The company has FDA approval for its oral medications aimed at patients at risk for cardiovascular disease, supported by the CLEAR Cardiovascular Outcomes Trial involving nearly 14,000 patients [6] - Esperion is advancing its next-generation program targeting ATP citrate lyase inhibitors (ACLYi), leveraging new insights for rational drug design [6][7] Offering Details - The shares are being offered under an effective shelf registration statement filed with the SEC on April 18, 2025, and declared effective on April 29, 2025 [3] - The offering will be conducted through a written prospectus and a preliminary prospectus supplement will be filed with the SEC [3][5] - Joint book-running managers for the offering are Piper Sandler & Co. and Cantor Fitzgerald & Co. [2][4]

Core Insights - Esperion has entered into a settlement agreement with Dr. Reddy's Laboratories, resolving patent litigation regarding generic versions of NEXLETOL and NEXLIZET, preventing Dr. Reddy's from marketing these generics in the U.S. before April 19, 2040, unless specific circumstances arise [1] - The settlement with Dr. Reddy's follows previous agreements with Micro Labs USA, Hetero USA, and Accord Healthcare concerning their generic versions of NEXLETOL, ensuring no remaining challenges to the validity of U.S. Patent No. 7,335,799, which expires in December 2030 [2] - Ongoing patent litigation against other defendants remains, with uncertainty regarding the potential for generic versions of NEXLETOL and NEXLIZET to be marketed before the April 2040 date [3] Company Overview - Esperion Therapeutics is a biopharmaceutical company focused on developing and commercializing FDA-approved oral medications for patients at risk for cardiovascular disease, specifically targeting elevated low-density lipoprotein cholesterol (LDL-C) [4] - The company is advancing its pre-clinical pipeline and aims to establish itself as a leading global biopharmaceutical entity through commercial execution and international partnerships [5]

Core Insights - Esperion has entered into a settlement agreement with Hetero USA, resolving patent litigation related to the generic version of NEXLETOL, preventing Hetero USA from marketing the generic in the U.S. before April 19, 2040, unless specific circumstances arise [1] - Ongoing patent litigation against other defendants regarding NEXLETOL and NEXLIZET continues, with no assurance on the outcome or potential market entry of generics before the 2040 date [2] Company Overview - Esperion Therapeutics is a commercial stage biopharmaceutical company focused on developing and marketing new medicines for patients at risk for cardiovascular disease, specifically offering FDA-approved oral, once-daily, non-statin medications for elevated LDL-C [3] - The company is advancing its next-generation program aimed at developing ATP citrate lyase inhibitors (ACLYi), leveraging new insights for rational drug design and the creation of potent inhibitors [3][4] - Esperion is evolving into a leading global biopharmaceutical company through commercial execution, international partnerships, collaborations, and the advancement of its pre-clinical pipeline [4]

Core Insights - Esperion has entered into a settlement agreement with Micro Labs USA, resolving patent litigation related to the generic version of NEXLETOL, preventing Micro Labs from marketing it in the U.S. before April 19, 2040, unless specific circumstances arise [1] - Ongoing patent litigation against other defendants regarding NEXLETOL and NEXLIZET continues, with no assurance of a generic version being marketed before the same date [2] Company Overview - Esperion Therapeutics is a commercial stage biopharmaceutical company focused on developing and marketing new medicines for patients at risk of cardiovascular disease, specifically offering FDA-approved oral, once-daily, non-statin medications for elevated LDL-C [3] - The company is advancing its pre-clinical pipeline and aims to evolve into a leading global biopharmaceutical entity through commercial execution and international partnerships [4]

Core Insights - Esperion is participating in the H.C. Wainwright 3rd Annual BioConnect Investor Conference on May 20, 2025, at 10 a.m. ET [1] - The company is focused on developing and commercializing FDA-approved oral, once-daily, non-statin medications for patients at risk for cardiovascular disease [2] - Esperion is advancing its next-generation program targeting ATP citrate lyase inhibitors (ACLYi) to create highly potent and specific inhibitors [2][3] Company Overview - Esperion Therapeutics is a commercial-stage biopharmaceutical company addressing unmet medical needs in cardiovascular health [2] - The company has conducted the CLEAR Cardiovascular Outcomes Trial involving nearly 14,000 patients to support its medications [2] - Esperion is evolving into a leading global biopharmaceutical company through commercial execution and international partnerships [3]