Kodiak®, Kodiak Sciences®, ABC®, ABC Platform , and the Kodiak logo are registered trademarks or trademarks of Kodiak Sciences Inc. in various global jurisdictions. THE OPHTHALMOLOGY MEDICINES COMPANY 44th Annual J.P. Morgan Healthcare Conference January 12, 2026 1 Forward-Looking Statements This presentation may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 and other federal securities laws, including statements regarding Kodiak's plans, commi ...

Core Insights - Kodiak Sciences Inc. reported significant advancements in its late-stage clinical assets, particularly focusing on the transformative potential of tarcocimab, KSI-501, and KSI-101 in treating retinal diseases [2][3]. Recent Business Highlights and Upcoming Catalysts - The company held an Investor R&D Day on July 16, 2025, showcasing new data and a commercial vision for its clinical assets [2]. - KSI-101 demonstrated rapid anatomical gains and visual acuity improvements in patients with macular edema secondary to inflammation (MESI) during the Phase 1b APEX study [5]. - Upcoming topline data for tarcocimab and KSI-501 is expected in 1Q 2026 and 3Q 2026, respectively, with KSI-101 data anticipated in 4Q 2026 to 1Q 2027 [5]. Financial Results - Kodiak ended Q2 2025 with $104.2 million in cash and cash equivalents, sufficient to support operations into 2026 [4]. - The net loss for Q2 2025 was $54.3 million, or $1.03 per share, compared to a net loss of $45.1 million, or $0.86 per share, in Q2 2024 [6]. - Research and development expenses rose to $42.8 million in Q2 2025 from $32.5 million in Q2 2024, driven by increased clinical activities [7]. Pipeline Programs - Tarcocimab is an investigational anti-VEGF therapy designed for extended durability in ocular tissues, with ongoing Phase 3 studies in diabetic retinopathy and wet AMD [9][10]. - KSI-501 is a bispecific therapy targeting IL-6 and VEGF, currently in the Phase 3 DAYBREAK study for wet AMD [17][19]. - KSI-101 is being developed for MESI, with ongoing Phase 3 studies (PEAK and PINNACLE) actively enrolling patients [22][26]. Digital Health Initiatives - The VETi program has made significant advancements in AI and machine learning, aimed at enhancing the company's commercial retina franchise [5]. Company Overview - Kodiak Sciences is focused on developing transformative therapeutics for retinal diseases, utilizing its proprietary ABC Platform to create next-generation retinal medicines [29].