Core Insights - Kodiak Sciences Inc. is a precommercial biotechnology company focused on developing transformative therapeutics for retinal diseases [3] Company Overview - Kodiak Sciences is dedicated to researching, developing, and commercializing next-generation retinal medicines aimed at preventing and treating leading causes of blindness globally [3] - The company is developing a portfolio of three late-stage clinical programs targeting the $15 billion anti-VEGF marketplace [3] - Two drug candidates, Tarcocimab and KSI-501, are in Phase 3 studies with topline data readouts expected in 1Q 2026 and 3Q 2026 respectively [3] - KSI-101, a bispecific protein, is also in two Phase 3 studies with topline data readouts expected in 4Q 2026 and 2Q 2027 [3] Upcoming Events - Senior management will present at the 44th Annual J.P. Morgan Healthcare Conference on January 12, 2026, at 1:30 p.m. Pacific Time [1] - A live webcast of the presentation will be available on Kodiak's website and will remain accessible for a limited time after the event [2]

Summary of Key Points from Biotechnology Equity Research Conference Call Industry Overview - The report focuses on the biotechnology sector, specifically highlighting companies with significant potential for growth and upcoming catalysts in 2026. Key Companies and Their Outlook 1. **Dianthus Therapeutics, Inc. (DNTH)** - Market Cap: $1.82 billion - Price Target: $66 - Key catalysts include: - CIDP Phase III interim analysis in Q2 2026 - Initiation of gMG Phase III study in mid-2026 - Phase II MMN topline data in 2H26 - Potential for significant upside based on peak revenue estimates of ~$2 billion across neuromuscular diseases [19][20][24] 2. **Taysha Gene Therapies, Inc. (TSHA)** - Market Cap: $1.50 billion - Price Target: $11 - Focus on pivotal study for TSHA-102 in Rett syndrome with potential for a 6-month interim readout by YE26/1Q27 [26][27] 3. **Tyra Biosciences (TYRA)** - Market Cap: $1.36 billion - Price Target: $32 - Major catalysts include: - Phase III data for achondroplasia in early 2026 - Initial data for IR-NMIBC in 1H26 - Potential to disrupt the market with oral FGFR3 inhibitors [31][35] 4. **Tango Therapeutics, Inc. (TNGX)** - Market Cap: $1.15 billion - Price Target: $14 - Expected to show de-risking data for vopimetostat in combination with RVMD's RAS inhibitors in 2026 [37][40] 5. **ORIC Pharmaceuticals (ORIC)** - Market Cap: $783 million - Price Target: $23 - Key catalysts include dose-optimization data for prostate cancer and validating data from PFE's MEVPRO-1 trial [42][48] 6. **Solid Biosciences (SLDB)** - Market Cap: $463 million - Price Target: $15 - Focus on DMD program with key regulatory feedback expected in 1H26 [49][53] Major Catalysts and Events - **Upcoming Catalysts:** - RARE and MREO Phase III ORBIT final analysis expected in Dec'25/Jan'26 with potential stock movements of +100%/-30% [2] - ALNY, CRSP, and others expected to provide revenue guidance and business plans early in 2026 [1] - Regulatory events including FDA's Rare Disease Day on 2/23/26 [12] - **Drug Launches:** - Expected launches in 2026 include drugs from ALNY, ARWR, KALV, and others targeting various conditions [3] Financial Updates - **Price Target Changes:** - ARWR raised from $67 to $90 - KOD raised from $24 to $39 [6][10] Market Dynamics - **Pricing Stability:** - 2026 net pricing expected to remain stable with current Medicare contracts influencing high gross-to-net (GTN) guidance [12] - **Strategic Interest:** - Potential for M&A activity as companies like ORIC attract interest due to their prostate cancer programs [43] Conclusion - The biotechnology sector is poised for significant developments in 2026, with multiple companies presenting strong investment opportunities based on upcoming catalysts, drug launches, and strategic positioning in the market.

U.S. stocks were higher, with the Dow Jones index gaining around 200 points on Wednesday.Shares of Dynavax Technologies Corp (NASDAQ:DVAX) rose sharply during Wednesday's session after Sanofi SA (NASDAQ:SNY) agreed to acquire the company for $15.50 per share in cash, reflecting a total equity value of approximately $2.2 billion.The acquisition augments Sanofi's presence in adult immunization.Dynavax shares jumped 38.6% to $15.44 on Wednesday.Here are some other big stocks recording gains in today’s session. ...

Core Insights - Jefferies has released a report on the outlook for the U.S. biotech industry in 2026, highlighting key clinical trial data disclosures, new drug approvals, and policy dynamics that could lead to value re-evaluation for companies in the sector [1] Six Preferred Stocks - Jefferies identified six companies as core recommendations for 2026 based on market catalysts and valuation potential: - Dianthus Therapeutics (DNTH.US), target price $66: Focused on claseprubart for various neuromuscular diseases, with peak revenue estimated at $2 billion [2] - Taysha Gene Therapies (TSHA.US), target price $11: TSHA-102 for Rett syndrome, with peak revenue potential of $2 billion and a key trial data disclosure expected by the end of 2026 [2] - Tyra Biosciences (TYRA.US), target price $32: Dabogratinib for bladder cancer and achondroplasia, with critical data expected next year [3] - Tango Therapeutics (TNGX.US), target price $14: Collaboration with Revolution Medicines for a pancreatic cancer treatment, with data expected in mid-2026 [3] - ORIC Pharmaceuticals (ORIC.US), target price $23: Two potential assets targeting prostate cancer and lung cancer, with key data expected next year [4] - Solid Biosciences (SLDB.US), target price $15: Focused on gene therapy for Duchenne muscular dystrophy, with critical meetings with the FDA planned for 2026 [4] Seven Undervalued Companies - The report also highlighted seven undervalued companies with significant catalysts: - Ultragenyx Pharmaceutical (RARE.US), target price $114: Expected key catalysts in 2026, including data for treatments for osteogenesis imperfecta and Angelman syndrome [5] - Beam Therapeutics (BEAM.US), target price $41: Updates on AATD therapy and SCD therapy expected in 2026, showcasing strong potential [5] - Aurinia Pharmaceuticals (AUPH.US), target price $21: Steady growth in lupus nephritis treatment, with new drug development paths expected to expand growth [6] - Kodiak Sciences (KOD.US), target price $39: Anticipated data from three pivotal trials in 2026, with significant potential for stock volatility [7] - Intellia Therapeutics (NTLA.US), target price $45: Key data for hereditary angioedema therapy expected in mid-2026, with sufficient cash reserves to support operations [7] - Compass Therapeutics (CMPX.US), target price $8: Data for cholangiocarcinoma therapy expected in early 2026, with a significant market opportunity [8] - KalVista Pharmaceuticals (KALV.US), target price $38: First oral treatment for hereditary angioedema expected to see rapid growth in 2026 [8] Five Potential Acquisition Targets - Jefferies identified five companies that may become acquisition targets in 2026 due to their unique assets or market positions: - Arrowhead Pharmaceuticals (ARWR.US): Strong RNAi product line for cardiovascular and metabolic diseases [9] - Celcuity (CELC.US): Unique efficacy of gedatolisib in breast cancer [9] - ORIC Pharmaceuticals: High-value prostate and lung cancer projects [9] - Travere Therapeutics (TVTX.US): Potential for significant market expansion in rare kidney diseases [9] - KalVista Pharmaceuticals: First-mover advantage in oral HAE treatment [9]

Key Takeaways Ionis Pharmaceuticals surged 127.6% in 2025 on progress across wholly-owned programs.GPCR jumped on phase II data showing up to 15.3% placebo-adjusted weight loss for oral GLP-1 aleniglipron.KOD rallied as late-stage tarcocimab and KSI-501 advance, with multiple phase III readouts slated for 2026.After a weak first half, the drug and biotech sector regained momentum in the latter part of 2025, setting the stage for a strong year for select stocks. Improved policy clarity following most large d ...

Several biotechnology and life sciences companies posted notable gains in after-hours trading on Friday, reflecting investor interest in recent clinical and corporate developments.Kura Oncology, Inc. (KURA) led the group with a strong move higher. Shares rose to $10.57, up 7.42% (+0.73) in after-hours trading. While there was no fresh news on Friday, investors may still be reacting to Kura's December 8 announcement of new data from its KOMET-007 Phase 1a/1b trial. The study evaluated KOMZIFTI (ziftomenib) ...

Core Insights - Kodiak Sciences Inc. successfully closed a public offering of 8,000,000 shares at a price of $23.00 per share, generating approximately $184 million in gross proceeds before expenses [1][3]. Company Overview - Kodiak Sciences is a precommercial biotechnology company focused on developing transformative therapeutics for retinal diseases, utilizing its proprietary ABC® Platform for next-generation retinal medicines [5]. Financial Position - The completion of the public offering strengthens Kodiak's financial position as it prepares for important Phase 3 topline readouts for its late-stage clinical assets: KSI-101, KSI-501, and tarcocimab [3]. Clinical Programs - Kodiak is advancing three late-stage clinical programs, with tarcocimab and KSI-501 in two BLA-facing Phase 3 studies for retinal vascular diseases, and KSI-101 being explored in two Phase 3 studies for Macular Edema Secondary to Inflammation (MESI) [5]. Underwriters - The offering was managed by J.P. Morgan, Jefferies, Evercore ISI, and UBS Investment Bank as joint book-running managers [2].

Group 1: Toro Co Performance - Toro Co reported quarterly earnings of 91 cents per share, exceeding the analyst consensus estimate of 87 cents per share [1] - The company achieved quarterly sales of $1.066 billion, surpassing the analyst consensus estimate of $1.048 billion [1] - Following the earnings report, Toro's shares rose by 7% to $77.82 [1] Group 2: Other Notable Stock Movements - DBV Technologies SA shares increased by 35.5% to $24.36 after meeting primary endpoints in the Phase 3 VITESSE trial [3] - Udemy Inc gained 26.5% to $6.79 due to an all-stock merger agreement with Coursera [3] - Kodiak Sciences Inc jumped 16.7% to $28.16 after announcing a public offering of common stock [3] - Hut 8 Corp rose 16.3% to $42.88 following a partnership to accelerate AI infrastructure deployment and a $7.0 billion lease agreement [3] - Canopy Growth Corp increased by 16.2% to $2.13 amid reports of potential reclassification of marijuana [3] - Recursion Pharmaceuticals Inc gained 13.2% to $4.76 after an upgrade from JP Morgan [3] - Two Harbors Investment Corp surged 13.2% to $11.21 due to an acquisition announcement [3] - Quantumscape Corp gained 7.7% to $11.66 after signing a joint development agreement with a top-10 global automaker [3] - Jabil Inc reported better-than-expected earnings, leading to a 7% increase in shares to $227.50 [3]

Core Viewpoint - Kodiak Sciences Inc. has announced an upsized underwritten public offering of 6,956,522 shares at a price of $23.00 per share, aiming to raise approximately $160 million in gross proceeds before expenses [1]. Company Overview - Kodiak Sciences is a precommercial biotechnology company focused on retinal therapeutics, utilizing its ABC® Platform to develop next-generation retinal medicines aimed at preventing and treating blindness [5]. - The company is currently advancing three late-stage clinical programs, including Tarcocimab and KSI-501 in Phase 3 studies for retinal vascular diseases, and KSI-101 in Phase 3 studies for Macular Edema Secondary to Inflammation [5]. Offering Details - The public offering is expected to close on or about December 18, 2025, subject to customary closing conditions [1]. - Kodiak Sciences has granted underwriters a 30-day option to purchase an additional 1,043,478 shares at the public offering price [1]. - The offering is conducted under a shelf registration statement previously filed with the SEC, which was declared effective on June 2, 2023 [3].

Core Viewpoint - Kodiak Sciences Inc. has initiated an underwritten public offering of 6,000,000 shares of its common stock, with an option for underwriters to purchase an additional 900,000 shares [1][2]. Company Overview - Kodiak Sciences is a precommercial biotechnology company focused on retinal therapeutics, aiming to develop transformative treatments for leading causes of blindness globally [5]. - The company utilizes its ABC® Platform, which integrates protein-based and chemistry-based therapies, to advance its research and development efforts [5]. - Kodiak is currently developing three late-stage clinical programs, including Tarcocimab and KSI-501 in Phase 3 studies for retinal vascular diseases, and KSI-101 for Macular Edema Secondary to Inflammation [5]. Offering Details - The proposed public offering is subject to market conditions, and there are no guarantees regarding its completion or the final terms [1]. - The shares are being offered under a shelf registration statement that was declared effective by the SEC on June 2, 2023 [3].