Core Insights - Basilea Pharmaceutica Ltd has received an additional USD 39 million from BARDA to advance the development of its antifungal drugs fosmanogepix and BAL2062, following the successful completion of a milestone under the "Other Transaction Agreement" [1][2] - The total potential funding from BARDA could reach approximately USD 268 million over up to 12 years, contingent on the successful completion of predefined milestones [1][2] Funding and Development - The new funding of USD 39 million is in addition to the initial USD 29 million committed by BARDA at the signing of the OTA in September 2024 [2] - BARDA's financial contribution is expected to cover about 60% of the total costs for the supported projects [2] - The funding will support ongoing phase 3 studies for fosmanogepix in yeast infections and the initiation of a second phase 3 study for mold infections, as well as preparations for a phase 2 study for BAL2062 [2] Product Information - Fosmanogepix is a clinical-stage broad-spectrum antifungal with a novel mechanism of action, effective against common and multi-drug-resistant strains of Candida and Aspergillus [3] - BAL2062 is a first-in-class antifungal derived from a natural product, showing fungicidal activity against important molds, including azole-resistant strains [4] Market Need - There is a high medical need for new antifungals due to the increasing incidence of difficult-to-treat infections, particularly among immunocompromised patients [2][5] - Invasive candidiasis is a significant nosocomial infection, with Candida species being a leading cause of bloodstream infections in hospitals [7]