Results reinforce telitacicept’s potential across multiple autoimmune diseases Data anticipated to be presented at an upcoming medical conference CAMBRIDGE, Mass., Aug. 27, 2025 (GLOBE NEWSWIRE) -- Vor Bio (Nasdaq: VOR), a clinical-stage biotechnology company transforming the treatment of autoimmune diseases, today announced that its collaborator, RemeGen Co., Ltd (HKEX: 9995, SHA: 688331), achieved the primary endpoint in Stage A of a Phase 3 clinical study in China evaluating telitacicept in adults with I ...

Core Insights - Telitacicept shows potential as a best-in-disease treatment for primary Sjögren's disease, achieving the primary endpoint in a Phase 3 clinical study in China [2][3] - The drug targets both BAFF and APRIL, addressing the autoimmune signaling cascade, which may allow for disease modification rather than just symptom management [3] - Vor Bio plans to submit a Biologics License Application (BLA) for telitacicept in primary Sjögren's disease, marking its fourth approved indication in China [4] Company Overview - Vor Bio is a clinical-stage biotechnology company focused on advancing telitacicept, a dual-target fusion protein, through Phase 3 clinical development to treat autoimmune diseases [5] - The company aims to transform treatment options for serious autoantibody-driven conditions globally [5] Product Details - Telitacicept is designed to selectively inhibit BLyS (BAFF) and APRIL, reducing autoreactive B cells and autoantibody production, which are key drivers of autoimmune diseases [6] - The drug is already approved in China for systemic lupus erythematosus, rheumatoid arthritis, and generalized myasthenia gravis [7] Disease Context - Primary Sjögren's disease is a chronic autoimmune condition characterized by overactive B cells, leading to inflammation and damage to moisture-producing glands [8] - The disease is often underdiagnosed, with significant impacts on patients' daily lives, and currently lacks systemic disease-modifying therapies [10]

Core Insights - Zenas BioPharma is advancing its obexelimab development program, with key clinical trials ongoing for autoimmune diseases, including the Phase 3 INDIGO trial for Immunoglobulin G4-Related Disease (IgG4-RD) and the Phase 2 MoonStone trial for Relapsing Multiple Sclerosis (RMS) [1][2][4] Clinical Trials - The Phase 3 INDIGO trial for IgG4-RD is the largest clinical trial conducted for this condition, with topline results expected around year-end 2025 [1][4] - Enrollment for the Phase 2 MoonStone trial in RMS has been completed, with results anticipated in early Q4 2025 [1][4] - The Phase 2 SunStone trial for Systemic Lupus Erythematosus (SLE) is expected to complete enrollment by year-end 2025, with topline results projected for mid-2026 [1][4] Financial Overview - As of June 30, 2025, Zenas BioPharma reported cash, cash equivalents, and investments totaling $274.9 million, which is expected to fund operations into Q4 2026 [1][4][16] - Research and development (R&D) expenses for Q2 2025 were $43.0 million, an increase from $33.8 million in Q2 2024, primarily due to higher clinical development costs for obexelimab [4][9] - General and administrative (G&A) expenses rose to $12.1 million in Q2 2025 from $5.9 million in Q2 2024, attributed to increased personnel costs and pre-commercialization activities [9][14] Product Information - Obexelimab is a bifunctional monoclonal antibody targeting CD19 and FcγRIIb, designed to inhibit B cell function without depleting them, potentially addressing chronic autoimmune diseases effectively [5][7] - The drug has shown pharmacologic activity in five completed clinical trials involving 198 subjects, indicating its potential as a potent B cell inhibitor [6]

Company Overview - Vor Bio is a clinical-stage biotechnology company focused on transforming the treatment of autoimmune diseases through innovative therapies [3] - The company is advancing telitacicept, a novel dual-target fusion protein, through Phase 3 clinical development and aims for commercialization to address serious autoantibody-driven conditions globally [3] Leadership Appointment - Dallan Murray has been appointed as Chief Commercial Officer, effective immediately, bringing over 25 years of experience in leading commercial strategy and product launches in the biotechnology and pharmaceutical sectors [2] - Murray previously served as Executive Vice President, Chief Customer Officer at Sarepta Therapeutics, where he led the commercial and medical affairs organizations, achieving approximately $1.8 billion in net product revenue in 2024 [2] Strategic Goals - The appointment of Murray is seen as crucial for Vor Bio as it prepares for the potential commercialization of telitacicept and shapes its broader growth strategy [2] - Murray expressed enthusiasm about the opportunity to bring much-needed treatments to patients worldwide and to help establish a strong commercial and strategic foundation for the company's long-term success [3]

Core Insights - Vor Bio has appointed Dr. Qing Zuraw as Chief Development Officer, bringing over 25 years of experience in clinical development for autoimmune diseases [1][2][4] - Dr. Zuraw previously led the development of telitacicept at RemeGen, achieving multiple regulatory approvals in China for systemic lupus erythematosus, generalized myasthenia gravis, and rheumatoid arthritis [2][3] - Vor Bio aims to advance telitacicept through Phase 3 clinical development and commercialization to address serious autoantibody-driven conditions globally [5] Company Overview - Vor Bio is a clinical-stage biotechnology company focused on transforming the treatment of autoimmune diseases [5] - The company is working on telitacicept, a novel dual-target fusion protein, to address serious conditions driven by autoantibodies [5] Leadership Experience - Dr. Zuraw has held senior roles at various pharmaceutical companies, including Janssen, Teva, and Biogen, where she led global clinical development programs [4] - She has been instrumental in achieving FDA approvals for therapies in multiple therapeutic areas, showcasing her capability in managing complex clinical trials [4]

Type 1 Diabetes (T1D) Program - Sana's hypoimmune platform (HIP) overcomes allogeneic rejection in people, which is confirmed by 4-week and 12-week data[4] - Type 1 diabetes affects 94 million children and adults, and is projected to affect 164 million by 2040[12, 13] - Type 1 diabetes leads to 201600 deaths per year and costs $81 billion worldwide annually[17] - SC451, a HIP-modified stem cell-derived pancreatic islet therapy, is advancing toward the clinic with an expected IND filing as early as 2026[114] - HIP-modified PSC differentiated islet cells transplanted into muscle persist & control blood glucose in mice for >15 months[64] Autoimmune Disease Program - B-cell mediated autoimmune diseases affect >5 million patients[68] - SC291, a HIP-modified CD19 CAR T, leads to deep B-cell depletion and has significant potential in B-cell mediated autoimmune diseases, with an ongoing GLEAM study[114] - Sana's T cell manufacturing process provides ~85% full knock-out of MHC class I and II, >995% TCR negative cells[79] - Fusogen platform offers the potential to treat B-cell mediated autoimmune diseases and B-cell cancers with NO lymphodepletion with an expected IND filing as early as 2026[114] Oncology Program - SC262, a HIP-modified CD22 CAR T, has meaningful potential in treating CD19 CAR T relapsed patients, with an ongoing VIVID study[114] - Estimated ~12000 B cell malignancy patients treated with CD19 CAR T in 2027, with ~35-40% durable complete responses, leading to ~7500 CAR T failures annually[106]

Core Insights - Vor Bio's shares have surged by 265.5% in the past week, significantly outperforming the industry average increase of 0.8% [1] - The company has entered a licensing agreement with RemeGen to develop and commercialize telitacicept in markets outside of China [1][6] Licensing Agreement Details - The licensing deal is valued at $125 million upfront, which includes $45 million in cash and $80 million in stock warrants, along with potential milestone payments exceeding $4 billion and tiered royalties on future sales [6][7] - Vor Bio will focus on developing telitacicept, a dual-target fusion protein that blocks two proteins, BAFF and APRIL, to treat autoimmune diseases [2][7] Clinical Development - A global phase III study for telitacicept in treating generalized myasthenia gravis (gMG) is currently ongoing in the United States, Europe, and South America, with initial data expected in the first half of 2027 [3] Leadership Changes - Vor Bio has appointed Jean-Paul Kress as the new CEO and chairman, following the resignation of the previous CEO, Robert Ang [3][6] Company Outlook - The licensing agreement is seen as a pivotal move that may prevent Vor Bio from shutting down its operations, which was previously announced due to financial difficulties [8]

Cullinan Therapeutics Licensing of velinotamig (BCMAxCD3) from Genrix Bio June 2025 © CULLINAN THERAPEUTICS, INC. ALL RIGHTS RESERVED. CONFIDENTIAL AND PROPRIETARY Important Notice and Disclaimers This presentation contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. These forward-looking statements include, but are not limited to, express or implied statements regarding Cullinan's beliefs and expectations regarding the potential benefits of, and pl ...

Core Viewpoint - Jade Biosciences is advancing its investigational anti-APRIL monoclonal antibody, JADE101, for the treatment of IgA nephropathy, with new preclinical data to be presented at the 62nd European Renal Association Congress [1][2]. Company Overview - Jade Biosciences, Inc. is a biotechnology company focused on developing therapies for autoimmune diseases, with its lead candidate, JADE101, targeting the cytokine APRIL for IgA nephropathy [5]. - The company plans to initiate a first-in-human clinical trial for JADE101 in the second half of 2025 [5]. Product Details - JADE101 is designed to reduce pathogenic IgA levels, decrease proteinuria, and preserve kidney function in patients with IgA nephropathy [4]. - The antibody is engineered with half-life extension technology, allowing for dosing at intervals of at least eight weeks, enhancing patient convenience [4]. Upcoming Events - Jade Biosciences will host a conference call and webcast on June 9, 2025, to discuss the new data on JADE101 presented at the ERA Congress [2][3]. - The presentation titled "Discovery and Characterization of JADE101" will occur during the Focused Oral Session on Glomerular and Tubulo-Interstitial Diseases on June 6, 2025 [6].

Obexelimab: A Differentiated B Cell Therapy - Obexelimab is a potentially highly differentiated I&I franchise molecule targeting autoimmune diseases [5] - It is the first bifunctional B cell targeting (CD19 x FcγRIIb) antibody in Phase 3 trial for IgG4-Related Disease and Phase 2 trials for RMS and SLE [6] - The company estimates a potential multi-billion-dollar commercial opportunity for Obexelimab [6, 45, 120] - Zenas BioPharma had approximately $314 million in cash as of Q1 2025, funding operations into Q4 2026 [6, 121] Clinical Development and Trial Readouts - Phase 3 topline results for the INDIGO trial in IgG4-RD are expected around year-end 2025 [46] - Phase 2 primary endpoint (12-week) data for the MoonStone trial in RMS is expected in early Q4 2025 [46] - Phase 2 primary endpoint (24-week) data for the SunStone trial in SLE is expected in mid-2026 [46] - The Phase 3 INDIGO trial in IgG4-RD has completed enrollment with approximately 190 patients [67] Market Opportunity and Strategic Collaboration - The estimated prevalence of IgG4-RD patients in the U S is approximately 20,000 to 40,000, and approximately 20,000 to 40,000 collectively in the UK, Germany, France, Italy, and Spain alone [52] - The company estimates that Obexelimab represents a compelling $1 billion+ commercial revenue opportunity in the U S alone for IgG4-RD [75] - Bristol Myers Squibb (BMS) has rights to develop and commercialize obexelimab in Japan, South Korea, Taiwan, Singapore, Hong Kong and Australia [47, 110]