Core Insights - Kane Biotech Inc. has successfully enrolled 28 participants in its revyve Antimicrobial Wound Gel and Spray U.S. Case Series Studies, surpassing the initial target of 25 participants [1] - The company’s products, including the revyve Antimicrobial Wound Gel and Spray, have received U.S. FDA 510(k) clearance, indicating regulatory approval for their use [3][4] - Data from the clinical series is expected to be presented at various medical meetings in 2025 and 2026, highlighting the growing interest from clinicians and patients [4] Company Overview - Kane Biotech is focused on developing innovative wound care treatments that target biofilms, which are significant contributors to antibiotic resistance in wounds [4] - The company aims to improve healing outcomes for patients suffering from challenging wounds and burns through its revyve product line [4] - The revyve products are designed to address both biofilms and wound bacteria, potentially transforming the treatment landscape for wound care [4]

Strategic Shift & Clinical Focus - SoftOx Solutions AS is refining its clinical focus towards chronic lung infections, particularly Cystic Fibrosis (CF), with SIS 003 as a Proof of Concept (PoC) [9, 15] - The Cystic Fibrosis (CF) pathway is a commercially valid and strategic first step, creating a foundation for long-term value creation in the inhaled pan-microbial pharmaceuticals space [17] - The company aims to transform antimicrobial therapy and combat antibiotic resistance with a novel mode of action that eradicates bacteria independent of metabolism [22] Market Opportunity & Commercial Potential - The Cystic Fibrosis (CF) addressable market is estimated to be greater than $600 million, with approximately 13,000 addressable patients in the US & EU4+UK, based on an annual treatment cost of $75,000/€20,000 [25, 53, 55] - The Non-Cystic Fibrosis Bronchiectasis (NCFB) addressable market is estimated to be greater than $5 billion, with approximately 445,000 addressable patients in the US & EU4+UK [31, 58] - Assuming a feasible market share of 15% in CF, the annual turnover potential is $90 million [55] Clinical Development & Investment - SoftOx plans to invest 7-8 million EUR to conclude Phase IIa and conduct partnership processes [45] - The company plans to submit a Clinical Trial Application (CTA) by the end of September 2025 for a Phase IIa PoC study in CF [45, 49] - The PoC study is designed to demonstrate a reduction in lung bacterial load in CF patients, with a primary endpoint of ≥ 2 log10 CFU/g reduction in bacterial load in expectorated sputum [41, 42, 51] Financial Flexibility - SoftOx has a financing facility with Long State Investment for a total commitment of NOK 50 million over 24 months, with the option to extend to NOK 80 million over 36 months [68]

Core Insights - Kane Biotech Inc. presented novel preclinical data and clinical case observations at major North American wound care conferences, showcasing the potential of its product revyve in wound care [1][2][3] Preclinical Data - In vitro studies demonstrated revyve's effectiveness in inhibiting key proteases, achieving over 80% reduction in matrix metalloproteinases (MMPs) activity, 82% reduction in elastase activity, and complete inhibition of collagenase and TACE [6][7] - Chronic wounds may exhibit TNF-α levels that exceed those in acute wounds by up to 100-fold, highlighting the need for effective treatments [2] Clinical Observations - Clinical case series indicated significant improvements in chronic wound patients using revyve, with clinically meaningful reductions in wound size and pain over a period of 6 to 12 weeks [6] - Specific cases reported include a 60% reduction in wound size over two months for a venous leg ulcer and complete pain elimination in a painful pressure wound [8] Conference Engagement - Kane Biotech engaged healthcare professionals at the NSWOCC and SAWC conferences, providing educational materials and product demonstrations of revyve [5][9] - The presentations aimed to reinforce the company's innovation in wound care and demonstrate the clinical value and commercial potential of revyve [9] Product Overview - Revyve is designed to address biofilms and wound bacteria, which are significant contributors to antibiotic resistance in wounds, potentially leading to serious clinical outcomes and high costs [9]

Company Overview - Kane Biotech Inc. is focused on developing innovative wound care treatments that target biofilms, which are significant contributors to antibiotic resistance in wounds [3] - The company's product, revyve™, is designed to address both biofilms and wound bacteria, aiming to improve healing outcomes [3] Event Participation - Dr. Robert Huizinga, the Interim CEO of Kane Biotech, will present at the Advanced Wound Care Summit USA from July 15-17, 2025, in Boston, MA [1][2] - The presentation will be accessible on Kane's website starting July 16, 2025 [2] Industry Context - The Advanced Wound Care Summit USA serves as a platform for industry stakeholders, including innovators, payers, regulators, and multinational leaders, to collaborate on advancing wound care therapies [2]

Core Points - Kane Biotech Inc. has completed the conversion of a $1 million unsecured demand loan from an insider into a 3% unsecured convertible debenture due on June 26, 2030 [1] - The closing of this transaction is subject to final approval from the TSX Venture Exchange [2] - At the Annual and Special Meeting of Shareholders, all resolutions were voted in favor with 98% or higher, including the election of three new board directors [3] Company Overview - Kane Biotech is focused on developing innovative wound care treatments that target biofilms, which contribute to antibiotic resistance in wounds, leading to serious clinical outcomes and high costs [4]

Core Viewpoint - Kane Biotech Inc. is undergoing a reorganization phase, which includes terminating its distribution agreement with ProgenaCare and addressing financial obligations with PrairiesCan while advancing its clinical plans for product introduction in the U.S. market [1][2][6]. Group 1: Distribution and Financial Agreements - The company has terminated its exclusive distribution agreement with ProgenaCare due to material breaches [1]. - Kane Biotech received a notice of default from PrairiesCan regarding a Contribution Agreement, which involved repayable contributions totaling $2,491,266, with repayments starting on April 1, 2023 [2]. - The company has made all required repayments except for the payment due on June 1, 2025, and is in communication with PrairiesCan to restructure the remaining loan repayments [2][3]. Group 2: Financing and Related Transactions - An insider provided an unsecured demand loan of $1 million, which will be converted into a five-year, unsecured convertible debenture, subject to TSX Venture Exchange approval [4]. - The debenture will accrue interest at 3% per annum and is convertible into common shares at a price of $0.10 per share [4]. - The conversion of the loan to the debenture is classified as a related party transaction, exempting the company from formal valuation and minority approval requirements [5]. Group 3: Clinical Development - The company is executing its clinical plan for the commercial introduction of its revyve Antimicrobial Wound Gel and Spray in the U.S. market [6]. - Clinical case series are being conducted with medical professionals in chronic wound care and burn care, with data expected to be presented in late 2025 and 2026 [6]. Group 4: Company Overview - Kane Biotech is focused on developing novel wound care treatments that target biofilms, which contribute to antibiotic resistance and adverse clinical outcomes [8].