Summary of Seer Conference Call (November 20, 2025) Company Overview - **Company**: Seer (NasdaqGS:SEER) - **Industry**: MedTech Diagnostics and Proteomics - **Product**: Proteograph Product Suite, including Proteograph One and SP200 Key Points and Arguments Product Development and Performance - Seer launched the Proteograph Product Suite to enable deep, unbiased proteomic analysis at scale, significantly improving throughput and reducing costs compared to earlier iterations [3][4] - The latest product, Proteograph One, was launched in June 2025, allowing customers to conduct larger studies with reduced assay time and increased sample throughput [4][5] - Notable studies include a 20,000-sample study by Korea University and a $50 million NIH-funded multi-center grant for a 50,000-sample study, where Seer was selected as the sole proteomic platform [5][6][7] Customer Validation and Publication Velocity - Since the launch of the first product in 2021, 66 customer papers have been published, with 13 published in Q3 2023 alone, indicating increasing customer validation and biological insights [7][8] - The establishment of Prognomic, a spin-out focused on liquid biopsy, has led to the development of a best-in-class lung cancer test, showcasing the effectiveness of Seer's platform [8][9] Market Adoption and Customer Feedback - Customer feedback on the Proteograph One has been positive, with a significant increase in instrument placements from 11 in the previous year to nearly 30 in the first nine months of 2025 [10][11] - The platform is being adopted for various applications, including neurodegenerative diseases and biomanufacturing, demonstrating its versatility [11][12] Strategic Partnerships - Seer has formed a partnership with Thermo, enhancing their market presence through co-sales, which allows Thermo sales representatives to offer Seer's Proteograph alongside their mass spectrometry instruments [25][26] - The combination of Seer's technology with Thermo's instruments provides a significant increase in the depth of proteomic analysis, achieving 8-10 times more protein identification compared to Thermo's instruments alone [26][27] Commercial Strategy and Customer Engagement - Seer's stack and Strategic Instrument Placement (SIP) programs have been effective in driving platform adoption, with a significant portion of instrument placements coming from former stack customers [30][33] - The SIP program allows customers to borrow instruments, facilitating adoption in budget-constrained academic and government settings [32][33] Financial Outlook and Capital Allocation - Seer ended Q3 2025 with approximately $251 million in cash and reaffirmed a break-even runway, focusing on diligent capital management while investing in innovation [35][37] - The company aims to reach a revenue scale of around $100 million, leveraging its strong balance sheet to potentially acquire less capital-intensive technologies [39][40] Future Developments - Seer anticipates an increase in population-scale studies, predicting that 2026 will see the first 100,000-sample study conducted using mass spectrometry [41][42] - The company is focused on generating biological insights from these studies to drive revenue growth [42] Additional Important Insights - The scientific community's skepticism towards new platforms is acknowledged, emphasizing the importance of evidence and robust performance in gaining institutional confidence [13][14] - The complexity of proteomics is highlighted, with a call for deeper analysis at the peptide level to uncover significant biological variations that could inform health and disease understanding [19][20][24]

Financial Performance & Restructuring - ProPhase Labs sold Pharmaloz Manufacturing for $23.6 million[11] - The company shut down the genomics laboratory, saving over $6 million per year[11] - ProPhase Labs is targeting over $50 million in net near-term cash recovery from COVID-19 receivables through an initiative with Crown Medical Collections[13, 15, 94] BE-Smart Esophageal Cancer Diagnostic - The BE-Smart test achieved greater than a 95% technical success rate in a key validation study, confirming its ability to reliably detect biomarkers[36, 95] - The total potential addressable market for the BE-Smart test is estimated at ~$7 billion - $14 billion[27] - The annual incidence change of Esophageal Adenocarcinoma (EAC) was 766.67% higher in 2017 compared to 1973[25] DNA Complete & Nebula Genomics - DNA Complete was launched on November 4, 2024, offering whole genome sequencing[11, 47] - DNA Complete analyzes virtually 100% of DNA, compared to less than 1% analyzed by typical DNA Ancestry tests[47] Equivir Dietary Supplement - Preliminary results from Equivir clinical trials showed that 37.7% of patients in the Equivir group acquired a viral infection versus 62.3% in the placebo group[78] - After 4 days of illness, only 3% of the Equivir group still had mild symptoms vs 55% in the placebo group[79]

Core Insights - Renovaro Inc. is expanding its strategic collaboration with Nebul to enhance early detection of cancer and other diseases through AI-driven precision medicine [1][2] - The partnership will utilize Renovaro's deep learning and machine learning programs alongside Nebul's high-performance computing capabilities to accelerate biomarker discovery and diagnostics [1][2] Company Overview - Renovaro Inc. focuses on precision and personalized medicine, leveraging AI and biotechnology for early diagnosis, targeted treatments, and drug discovery [4] - The company includes divisions such as RenovaroBio, which specializes in cell-gene immunotherapy, and RenovaroCube, which utilizes AI for multi-omic diagnostics and drug development [4] Partnership Details - The collaboration with Nebul aims to develop an improved diagnostic test for lung cancer that can detect minimal residual disease (MRD), which is crucial for preventing patient relapse [2] - Nebul's data centers will provide the necessary high-performance computing power, secure infrastructure, and scalability for Renovaro's deep learning AI models [2] Nebul Overview - Nebul offers a European private AI cloud that combines enterprise-class capabilities with the scalability of global hyper-scalers, ensuring secure processing of healthcare data [3] - The company has achieved certifications such as NEN 7510 and ISO 27001, demonstrating compliance with stringent standards for data security in healthcare applications [3]