Table of Contents As filed with the Securities and Exchange Commission on April 18, 2024 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Spyre Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 46-4312787 (State or other jurisdiction of incorporation or organization) (I.R.S. Employer Identification No.) 221 Crescent Street Building 23, Suite 105 Waltham, MA 02453 (61 ...

Table of Contents As filed with the Securities and Exchange Commission on January 18, 2024 Registration No. 333-276350 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO.1 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 CG ONCOLOGY, INC. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) Delaware 2836 37-1611499 (Primary Standard Industrial Classification Code Number) (I.R.S. Employer Identi ...