Group 1 - Creative Medical Technology Holdings, Inc. has received a Notice of Allowance for a U.S. patent related to the treatment of Type 1 Diabetes, which will be effective until at least 2040 [1][4] - The patent supports a cell-based immunotherapy approach using the ImmCelz product, which involves supercharged T regulatory cells derived from patients with Type 1 Diabetes [2][5] - Type 1 Diabetes is characterized by the immune system attacking insulin-producing beta cells in the pancreas, leading to insulin deficiency [3] Group 2 - The CEO of Creative Medical emphasizes that the use of ImmCelz represents regenerative immunotherapy and highlights the ongoing CREATE-1 clinical trial focused on Type 1 Diabetes [4] - The ImmCelz platform reprograms a patient's immune cells with optimized cell-free factors, enhancing their regenerative properties for potential treatment of various conditions [5][6] - Creative Medical is a clinical-stage biotechnology company specializing in regenerative medicine solutions across multiple indications, including pain management and neurology [6]

As filed with the U.S. Securities and Exchange Commission on March 15, 2023 Registration No. 333-268456 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 3 to FORM F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 CytoMed Therapeutics Limited (Exact Name of Registrant as Specified in its Charter) Not Applicable (Translation of Registrant's name into English) (State or Other Jurisdiction of Incorporation or Organization) Singapore 2834 Not Applicable (Primary Sta ...

As filed with the U.S. Securities and Exchange Commission on February 21, 2023 Registration No. 333-268456 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 2 to FORM F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 CytoMed Therapeutics Limited (Exact Name of Registrant as Specified in its Charter) Not Applicable (Translation of Registrant's name into English) (State or Other Jurisdiction of Incorporation or Organization) Singapore 2834 Not Applicable (Primary ...