Core Insights - Neurocrine Biosciences has initiated a Phase 1 first-in-human clinical study for the investigational compound NBIP-01435, aimed at treating congenital adrenal hyperplasia (CAH) [1][2] - NBIP-01435 is a long-acting corticotropin-releasing factor type 1 receptor antagonist, which may improve androgen control and allow for lower glucocorticoid dosing [3] - The company has a strong commitment to expanding treatment options for CAH, with NBIP-01435 being the first investigational peptide from its biologics pipeline to enter clinical trials [2][4] Company Overview - Neurocrine Biosciences is a leading biopharmaceutical company focused on neuroscience, dedicated to developing treatments for neurological, neuroendocrine, and neuropsychiatric disorders [5] - The company has a diverse portfolio that includes FDA-approved treatments for various conditions, including CAH, and a robust pipeline with multiple compounds in mid- to late-phase clinical development [5] - In December 2024, Neurocrine received FDA approval for crinecerfont, marking the first new treatment for CAH in 70 years [3]