Healthcare - Eli Lilly's orforglipron demonstrated superior results in the ACHIEVE-3 Phase 3 trial, achieving a 2.2% reduction in A1C compared to a 1.4% reduction for oral semaglutide [2][3] - Participants on the 36 mg dose of orforglipron lost an average of 19.7 lbs (9.2%), while those on oral semaglutide lost 11.0 lbs (5.3%) [3] Banking - Toronto-Dominion Bank reported an adjusted EPS of CAD 2.44 for Q1, exceeding the IBES estimate of CAD 2.26, with adjusted revenue of CAD 16.63 billion [4][5] - The bank set aside CAD 1.04 billion in credit loss provisions, indicating a cautious outlook on the credit environment, while maintaining a CET1 capital ratio of 14.5% [5] Geopolitics - Danish Prime Minister Mette Frederiksen announced a parliamentary election for March 24, addressing tensions related to Greenland and proposing a new wealth tax targeting the richest citizens [6] - The Sudan Core Group warned of potential war crimes in El Fasher, while Iran has proposed new ideas for a nuclear agreement [7] Tech & Safety - Meta Platforms is enhancing parental controls on Instagram, notifying parents if teens search for terms related to suicide or self-harm [8][9] - The company is also developing notifications for AI conversations, allowing parents to monitor interactions between teens and Meta's AI tools [9] Automotive - Stellantis is deepening its joint venture with Leapmotor to integrate Chinese EV technology into affordable European models, responding to the influx of low-cost Chinese electric vehicles [10][12][13] Politics - U.S. Senators are investigating Howard Lutnick over potential conflicts of interest related to his firm's ties to USA Rare Earth and financial products linked to tariff outcomes [14]