Epigenetic therapies

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Bausch Health Completes Acquisition of DURECT Corporation, Expanding Late-stage Liver Disease Portfolio
Prnewswire· 2025-09-11 12:35
Accessibility StatementSkip Navigation The transaction adds larsucosterol, an FDA Breakthrough Therapy for alcohol-associated hepatitis with a registrational Phase 3 clinical trial in development, to Bausch Health's hepatology pipeline LAVAL, QC, and CUPERTINO, Calif., Sept. 11, 2025 /PRNewswire/ -- Bausch Health Companies Inc. (NYSE: BHC) (TSX: BHC) ("Bausch Health"), a global, diversified pharmaceutical company, today announced the successful completion of its previously announced tender offer to acquir ...
DURECT Corporation Reports Second Quarter 2025 Financial Results and Provides Update on Proposed Acquisition by Bausch Health
Prnewswire· 2025-08-12 20:30
Core Viewpoint - DURECT Corporation has entered into a merger agreement with Bausch Health, where Bausch Health will acquire DURECT for $1.75 per share, with potential additional milestone payments totaling up to $350 million, expected to close in Q3 2025 [1][2]. Financial Highlights - For the second quarter ended June 30, 2025, DURECT reported total revenues of $447,000, a decrease from $646,000 in the same period of 2024. The net loss for the quarter was $2.3 million, compared to a net loss of $3.7 million in Q2 2024 [5][11]. - As of June 30, 2025, DURECT had cash, cash equivalents, and investments totaling $6.7 million, down from $12.0 million at the end of 2024 [5][12]. Merger Agreement Details - The merger agreement stipulates an upfront cash payment of approximately $63 million at closing, with additional milestone payments contingent on the commercial success of DURECT's lead drug candidate, larsucosterol, before December 31, 2045 [2][3]. - The tender offer for DURECT's outstanding shares commenced on August 12, 2025, and the merger is anticipated to be completed in the third quarter of 2025 [2][3]. Product Development - DURECT is focused on developing epigenetic therapies, particularly larsucosterol, which is in clinical development for treating alcohol-associated hepatitis (AH) and has received Fast Track and Breakthrough Therapy designations from the FDA [5][6].