Technology & Procedure - Hystotripsy, utilizing targeted ultrasound waves, offers a non-invasive method for tumor destruction [2] - The Edison system by HystoSonics is currently the only commercially available hystotripsy machine for human use [2] - Hystotripsy mechanically destroys tumor cells by rapidly expanding and contracting gases within them, liquefying the tissue instantly [7] - The procedure typically takes 1 to 3 hours, depending on the number of tumors targeted [18] Clinical Trials & Applications - Hystotripsy received FDA approval in October 2023 and is expanding availability [20] - While primarily focused on liver tumors, hystotripsy has potential applications for tumors in other organs [13] - Trials are underway for kidney and pancreatic tumors, with US availability for pancreatic tumor treatment expected in 2026 [15][16] - Future trials may explore applications for prostate (BPH and cancer), uterine fibroids, breast tumors, thyroid nodules, and even brain tumors [17] Post-Procedure & Immune Response - Most patients can return home a few hours after the procedure [19] - The body's immune system naturally absorbs the liquefied tumor [11] - Animal studies suggest hystotripsy may offer a systemic immunologic benefit by exposing hidden tumor antigens to the immune system [11][12]