Group 1: TransMedics Group - TransMedics Group is innovating the organ transplant market by addressing the challenges of organ storage and preservation, which traditionally has poor outcomes with cold storage methods [2][3] - The company developed the Organ Care System (OCS), which maintains organs in optimal condition for transplant, achieving a usage rate of 87% for lungs compared to 23% for cold storage, leading to fewer post-transplant complications [3] - In Q3, TransMedics reported revenue of $143.8 million, a 32% increase year-over-year, with net earnings per share rising to $0.66 from $0.12 [6] - The company is expanding its National OCS Program (NOP) to improve organ procurement and transport, which has been crucial for business growth [8] - TransMedics has partnered with Mercedes-Benz for ground transport in Italy, aiming to enhance its service in Europe, which could positively impact revenue [9] - The company is also developing a next-generation OCS system for other organs, anticipating steady growth in organ transplants over the coming years [10] Group 2: Abivax Société Anonyme - Abivax is a clinical-stage biotech company based in France, focusing on the development of obefazimod for ulcerative colitis (UC), which has shown promising late-stage clinical trial results [11] - The competitive landscape for UC treatments includes established therapies from major pharmaceutical companies, but Abivax's obefazimod could target a larger patient pool, particularly those with inadequate responses to existing therapies [12][13] - The stock has surged over 1,000% since January, with a market cap of approximately $9 billion, indicating strong investor interest [14][15] - Abivax plans to submit for regulatory approval in the U.S. in the second half of 2026, contingent on the success of ongoing trials, and is also exploring other indications for obefazimod, such as Crohn's disease [15] - Despite the potential for obefazimod to achieve blockbuster status, there are risks associated with regulatory and clinical trial outcomes, making it a high-risk investment [16][17]

"Transplantation is a logistics issue... We as an industry have to evolve."Lisa Anderson, Ph.D., cofounder and President at @ParagonixSherpa, spoke about transforming the organ transplant experience at the 2025 #ForbesHealth Summit. https://t.co/Kya2dmUf6U https://t.co/Zw8oCWbz7k ...

Summary of United Therapeutics Conference Call Company Overview - **Company**: United Therapeutics (NasdaqGS: UTHR) - **Event**: Jefferies Linden Healthcare Conference 2025 - **Date**: November 18, 2025 Key Points Current Commercial Business - **Revenue Growth**: United Therapeutics reported significant growth in total revenue, particularly from Tyvaso and Tyvaso DPI, which are expected to be the main growth drivers moving forward [4][6] - **Tyvaso DPI**: The product has no dosing limitations, is well-received by prescribers and patients, and has a favorable product profile, including ease of use [5][6] - **Market Position**: The company believes it is well-positioned in the pulmonary space, with a strong understanding of the market dynamics [4][6] Competitive Landscape - **Utrepia Launch**: Despite the launch of Utrepia, a competing product, United Therapeutics has seen a return in referrals and start trends towards Tyvaso, indicating strong market positioning [11][12] - **Market Expansion**: The presence of more therapies in the market is expected to expand the overall patient population rather than create a zero-sum game [13][14] Litigation Concerns - **Ongoing Litigation**: The company is awaiting a ruling on litigation related to Utrepia but remains confident in its growth trajectory regardless of the outcome [15][17][18] Future Projections - **Revenue Target**: United Therapeutics aims for a quarterly revenue run rate of $1 billion by the end of 2027, primarily driven by existing commercial products [19][21] - **IPF Opportunity**: The company sees a significant market opportunity in idiopathic pulmonary fibrosis (IPF), with an estimated 100,000 patients in the U.S. and a multi-billion dollar market potential [25][34] Clinical Trials and Pipeline - **Teton Trials**: The Teton 2 trial for IPF showed promising results, and there is high conviction that these results will translate to the Teton 1 trial in the U.S. [28][31] - **Regulatory Strategy**: The company plans to meet with the FDA to discuss the approval process for Tyvaso in IPF, aiming to expedite market entry [32][33] Additional Opportunities - **PPF and Rilendipag**: The company is optimistic about the potential for Tyvaso in pulmonary fibrosis (PPF) and is conducting trials for Rilendipag, an oral therapy expected to read out in 2026 [36][38] - **Xenotransplantation**: United Therapeutics is exploring organ transplantation, having conducted its first kidney transplant in a clinical trial, with plans to expand into lung and heart transplants [43][44] Financial Position and Strategy - **Overall Strategy**: The company is confident in its commercial pipeline and long-term organ manufacturing strategy, indicating a strong financial position [46][47] Conclusion United Therapeutics is positioned for significant growth driven by its existing products, promising clinical trials, and strategic market expansion. The company remains optimistic about its future revenue targets and the potential impact of its innovative therapies in the pulmonary and transplant markets.

“Everybody clapped.” @LVRiella tells “Babbage” about the first time his team transplanted a pig organ into a human https://t.co/Sg6f6ESbDh ...

Q3 2025 Performance - Product revenue reached $87.7 million, representing a 33.1% year-over-year growth but an 8.8% decrease compared to the previous quarter[3] - Total revenue for Q3 2025 was $143.8 million, a 32.2% increase year-over-year but an 8.6% decrease quarter-over-quarter[4] - Service revenue amounted to $56.1 million, showing a 30.9% year-over-year growth but an 8.4% decrease from the previous quarter[5] - Net income for Q3 2025 was $24.3 million, a significant increase of $20.1 million year-over-year but a decrease of $10.6 million quarter-over-quarter[5] - Total cash reached $466.2 million, an increase of $65.6 million quarter-over-quarter[5] Revenue Breakdown by Organ - Liver revenue was $107.94 million, a 40.8% increase year-over-year but a 7.0% decrease quarter-over-quarter[11, 16] - Heart revenue was $30.589 million, a 13.6% increase year-over-year and a 14.2% decrease quarter-over-quarter[11, 16] - Lung revenue was $4.11 million, a 5.2% increase year-over-year and a 10.2% decrease quarter-over-quarter[11, 16] Service Revenue Details - Clinical service revenue decreased by 8.7% quarter-over-quarter but increased by 29.0% year-over-year[14] - Logistics revenue decreased by 8.9% quarter-over-quarter but increased by 35.2% year-over-year[14] - Flight school revenue increased by 15.7% quarter-over-quarter but decreased by 5.7% year-over-year[14] Financial Metrics - Gross margin for Q3 2025 was 58.8%, a 2.9 percentage point increase year-over-year but a 2.6 percentage point decrease quarter-over-quarter[4] - Operating margin for Q3 2025 was 16.2%, a 12.6 percentage point increase year-over-year[4] Updated 2025 Revenue Guidance - The company updated its total revenue guidance for 2025 to a range of $595 million to $605 million, projecting a 36% growth at the midpoint of the range[20]

Core Insights - The article emphasizes that cellular regeneration, rather than organ transplantation, is the key to extending human healthspan and lifespan [1][17][23] Scientific Contributions - European Wellness Biomedical Group (EWBG) published the Human Cytology Atlas, mapping over 400 distinct human cell types, and a peer-reviewed study on organ aging [1][9][27] - The Human Cytology Atlas serves as a reference for understanding cellular diversity and its implications for precision medicine [10][27] Aging Mechanisms - Different organs age at varying rates, which is crucial for developing targeted interventions [12][27] - The cardiovascular and immune systems decline early, while the liver and kidneys show staggered vulnerability [12] Future of Medicine - The future of medicine is seen in the transplantation of cells rather than organs, focusing on repairing and rejuvenating life at the cellular level [8][21][27] - Protocols for healthspan are being tested, emphasizing the importance of extending healthy years over mere longevity [19][20] Global Collaborations - Prof. Mike Chan's work includes collaborations with institutions in Baoding, Germany, and Switzerland, focusing on cell-based therapies and training programs for physicians [20][27] Vision for Longevity - The article presents a shift in the conversation around longevity from speculative immortality to a science-driven focus on healthspan, which relies on cellspan [23][18]

Company Focus - Startup aims to grow new mini-organs in patients [1] Industry - The report discusses a startup in the field of organ growth [1]

Startup Focus - Startup aims to grow new mini-organs in patients [1] Industry Focus - Biotechnology industry is exploring innovative approaches to regenerative medicine [1]

Company Focus - Startup aims to grow new mini-organs in patients [1] Industry - Biotechnology industry focuses on innovative approaches to organ regeneration [1]

Financial Data and Key Metrics Changes - The company announced a sale of the Blade passenger business to Joby Aviation for up to $125 million, which is expected to create long-term value for stakeholders [6][9] - Medical revenue grew 17.6% year-over-year to a record $45.1 million in Q2 2025, driven by new transplant center customers and increased demand [18][26] - Adjusted EBITDA margin for the medical segment rose to 13.4% in Q2 2025, compared to 11.4% in Q1 2025, but declined from 14.4% in Q2 2024 [18][20] Business Line Data and Key Metrics Changes - The medical business accounted for approximately 60% of revenue in 2024, up from 12% in 2020, and contributed about 85% of the segment's adjusted EBITDA [6][9] - The passenger business saw a 5.5% decrease in short-distance revenue year-over-year, primarily due to lower revenue in the US segment [20] - The passenger segment adjusted EBITDA tripled year-over-year from $800,000 to $2.4 million, driven by improved flight margins and lower SG&A expenses [22] Market Data and Key Metrics Changes - The company exited the Canadian market in August 2024, impacting short-distance revenue in the US [20] - European operations showed strong revenue growth due to realignment with local partners and operational changes [21] Company Strategy and Development Direction - The company aims to focus on its medical division as a standalone entity, which will be renamed Strata Critical Medical, emphasizing its growth potential in the medical sector [6][9] - A disciplined capital allocation strategy is planned, supported by approximately $200 million in cash from the passenger business sale [12][26] - The company is entering a long-term partnership with Joby Aviation to access eVTOL aircraft for medical use, enhancing its service offerings [15][32] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the growth prospects of the medical business, expecting mid-teens revenue growth in the second half of 2025 [26] - The company anticipates improved fleet uptime and adjusted EBITDA margins in the medical segment, projecting margins of approximately 15% [26] - Management noted that the divestiture is expected to be neutral to adjusted EBITDA and free cash flow on a go-forward basis [25][26] Other Important Information - The company ended the quarter with no debt and $113.4 million in cash and short-term investments [25] - The financial impact of the divestiture is expected to be adjusted EBITDA and free cash flow neutral, supported by estimated corporate cost efficiencies of $7 million [10][25] Q&A Session Summary Question: What are the current priorities for capital allocation post-transaction? - Management highlighted opportunities in M&A and organic growth, emphasizing the need for capital to scale the business effectively [29][30] Question: Are there any operational impacts from the divestiture on the medical segment? - Management stated that the company is set up for success as a standalone entity and expects the partnership with Joby to add significant value [32][33] Question: Why was the passenger business sold now? - Management indicated that the market was discounting the value of the passenger business, and the divestiture allows for a clearer focus on the high-growth medical segment [37][38] Question: What is the growth outlook for the medical business? - Management expressed optimism about organic growth driven by new technologies and services, aiming for high teens adjusted EBITDA margins in the long term [41][43] Question: How is the business trending quarter to date? - Management reported strong performance in July, with no signs of seasonal slowdown yet [44] Question: What are the tax implications of the transaction? - Management noted that they have enough NOLs to offset capital gains from the divestiture, expecting minimal cash tax impact [46]