法国生物技术公司Abivax(ABVX.US)盘初大涨超10%，报135.65美元，创历史新高。消息面上，市场猜 测礼来可能有意收购Abivax，礼来对此传闻表示：不对业务发展活动发表评论。此外，LifeSci Capital 维持对Abivax的"买入"评级，目标价为170美元。Abivax公司曾于7月报告obefazimod在溃疡性结肠炎治 疗中的三期临床试验积极结果。(格隆汇) ...

本文源自：格隆汇 法国生物技术公司Abivax(ABVX.US)盘前涨10.5%，报135.97美元。消息面上，市场猜测礼来可能有意 收购Abivax，礼来对此传闻表示：不对业务发展活动发表评论。Abivax公司曾于7月报告obefazimod在 溃疡性结肠炎治疗中的三期临床试验积极结果。 ...

法国生物技术公司Abivax(ABVX.US)盘前涨10.5%，报135.97美元。消息面上，市场猜测礼来可能有意 收购Abivax，礼来对此传闻表示：不对业务发展活动发表评论。Abivax公司曾于7月报告obefazimod在 溃疡性结肠炎治疗中的三期临床试验积极结果。(格隆汇) ...

智通财经APP获悉，法国生物科技公司Abivax(ABVX.US)周三在巴黎股市和美股盘前走高，此次有报道 指出，此番股价异动源于市场对减肥药巨头礼来(LLY.US)可能发起收购要约的猜测。 事实上，这家总部位于巴黎的企业早已不是首次卷入收购传闻。金融情报机构Betaville此前于9月和11 月两度发布关于Abivax可能被收购的"未经核实"市场猜测，均曾推动其美国存托凭证(ADR)价格上涨。 回溯今年7月，Abivax曾公布重磅利好：其每日一次口服的obefazimod，在两项治疗溃疡性结肠炎的Ⅲ 期临床试验中均达到主要终点，消息一出，公司股价随即迎来暴涨。 作为一家临床阶段生物科技企业，Abivax的核心在研产品obefazimod主要用于治疗溃疡性结肠炎等炎症 性疾病。截至发稿，该公司股价在巴黎股市上涨逾10%，对应市值攀升至约80亿欧元(折合93亿美元)， 较今年年初5亿欧元的估值实现大幅跃升。美股盘前，该股涨超9%。 "此番股价波动的核心驱动因素，是市场对于潜在收购交易的猜测，"Stifel分析师Damien Choplain表 示。 礼来对此回应称："我们不对业务发展活动发表评论。" ...

These companies are worth your attention.Looking for stocks with explosive growth potential? Look no further than TransMedics Group (TMDX 1.32%) and Abivax Société Anonyme (ABVX +6.94%). Both healthcare specialists have seen their shares jump significantly this year already.However, there could be plenty more upside on the way for these little-known stocks. Here's why TransMedics Group and Abivax might be worth considering, especially for investors with an elevated risk tolerance.1. TransMedics GroupTransMe ...

Core Viewpoint - Abivax, a French biotechnology company, has seen its market capitalization surge from under $500 million at the beginning of the year to over $8 billion, driven by positive data from its experimental drug for chronic inflammatory bowel disease [1] Group 1: Drug Potential - Investors are focused on the potential of Abivax's obefazimod for ulcerative colitis patients, with results expected in Q2 2026, which could lead to regulatory submission [2] - The company plans to release mid-stage trial results for obefazimod in treating Crohn's disease later this year [2] - Obefazimod is designed to regulate inflammation through upregulating a microRNA called miR-124, offering a differentiated safety profile compared to existing treatments [5][6] Group 2: Market Opportunity - Wolfe Research analysts estimate obefazimod could achieve peak sales of approximately €6 billion ($7 billion) and capture a significant market share in treating ulcerative colitis and Crohn's disease [6] - The inflammatory bowel disease (IBD) market is projected to reach around $30 billion by 2030 [6] Group 3: Acquisition Interest - Abivax is viewed as a potential acquisition target, with Truist Securities highlighting its strategic appeal [7] - Goldman Sachs has included Abivax in its list of stocks favored by hedge funds [7] Group 4: Analyst Sentiment - Wall Street analysts have a consensus rating of "Buy" or "Strong Buy" for Abivax, with an average target price between $120 and $130 [11]

Core Viewpoint - A rotation in investor interest is occurring, moving from high-flying tech stocks to undervalued healthcare stocks, driven by strong earnings and emerging uptrends in the healthcare sector [1]. Group 1: Healthcare Sector Overview - The healthcare sector is experiencing a surge, with several stocks showing strong momentum and favorable rankings on Benzinga's Momentum scores [2]. - Investors are increasingly favoring healthcare stocks due to their strong earnings performance and technical indicators suggesting upward trends [1]. Group 2: Cardinal Health Inc. - Cardinal Health (NYSE:CAH) has a market cap of $48 billion and has consistently generated over $50 billion in sales each quarter since Q1 2023, primarily from generic and branded drug sales [4]. - The stock has increased over 70% year-to-date, with a significant 15% jump following a Q3 earnings report that exceeded consensus expectations by more than 16% [6]. Group 3: Guardant Health Inc. - Guardant Health (NASDAQ:GH) specializes in oncology diagnostics and reported a record revenue of $265 million, reflecting over 38% year-over-year growth [9]. - The stock has shown strong momentum, with a significant increase following better-than-expected earnings results [9]. Group 4: Abivax SA - Abivax (NASDAQ:ABVX) focuses on chronic inflammatory diseases and has seen its stock rise nearly 600% in a single session following positive Phase 3 clinical trial results [10]. - The stock has continued to rise, with a 60% increase over the last three months and a consensus Buy rating from analysts [12]. Group 5: Medpace Holdings Inc. - Medpace (NASDAQ:MEDP) provides clinical trial services and has experienced a stock increase of over 75% year-to-date, driven by strong earnings performance [13]. - The company reported Q3 revenue growth of more than 23% year-over-year, exceeding expectations and indicating strong future prospects [15]. Group 6: Elanco Animal Health Inc. - Elanco Animal Health (NYSE:ELAN) develops healthcare products for pets and farm animals, with shares up 76% this year due to solid earnings [16]. - The company raised its full-year guidance following strong sales growth in both its Pet Health and Farm Animal divisions [18]. Group 7: GeneDx Holdings Corp. - GeneDx Holdings (NASDAQ:WGS) specializes in exome and genome testing and has recently turned a profit, with a market cap approaching $4 billion [19]. - The company has raised guidance for total revenue and adjusted gross margins, indicating strong growth potential [19].

Core Insights - Abivax announced significant improvements in patient-reported outcomes (PRO) from its Phase 3 ABTECT trials for obefazimod, indicating its potential to enhance the quality of life for patients with moderate-to-severely active ulcerative colitis [2][5] Summary by Categories Clinical Trial Results - The Phase 3 ABTECT trials demonstrated that 37% of patients on 50mg obefazimod reported no bowel urgency at week 8, compared to 18.1% in the placebo group (p<0.0001) [6] - 47.6% of patients on 50mg obefazimod reported no nocturnal bowel movements at week 8, compared to 24.7% in the placebo group (p<0.0001) [6] - Fatigue remission was reported by 17.1% of patients on 50mg obefazimod at week 8, compared to 7.7% in the placebo group (p=0.0001) [6] Patient-Reported Outcomes - PRO instruments evaluated included bowel urgency, nocturnal bowel movements, fatigue, overall quality of life, and workplace productivity [7] - Consistent improvements across all PRO instruments were observed, underscoring the meaningful benefits of obefazimod for patients' daily experiences [3][5] Future Developments - Abivax plans to present detailed PRO data at an upcoming medical conference and anticipates sharing results from a 44-week maintenance trial in the second quarter of 2026 [4][5] - The company is focused on developing effective and tolerable long-term therapies for ulcerative colitis [5][8]

Core Insights - The biotech sector is experiencing significant momentum, with many clinical-stage and commercial biopharma stocks reaching new 52-week highs due to breakthrough trial data, strategic deals, and earnings surprises [1] Company Summaries - **Metsera Inc. (MTSR)**: A clinical-stage biopharmaceutical company focused on developing hormone analog peptides for obesity and related metabolic diseases. Recently, Novo Nordisk made a $9 billion unsolicited acquisition proposal, which Metsera's board considers superior to its existing agreement with Pfizer [2][3]. Metsera announced positive Phase 2b results for its GLP-1 receptor agonist MET-097i, showing up to 14.1% weight loss after 28 weeks, supporting Phase 3 initiation in late 2025 [4]. The stock rose from $32.35 to a 52-week high of $66.10, a gain of 104.3% [5]. - **Indivior Plc (INDV)**: Develops buprenorphine-based therapies for opioid dependence. The company reported Q3 net income of $42 million, up from $22 million a year ago, with adjusted earnings of $93 million, exceeding Wall Street's expectations [6][7]. The stock increased from $20.86 to a 52-week high of $30.55, reflecting a 46.5% gain [7]. - **Insmed Inc. (INSM)**: Focused on therapies for serious and rare diseases, Insmed reported a Q3 net loss of $370 million but saw net product revenue rise to $142.3 million from $93.4 million last year [8][9]. The company raised its full-year 2025 revenue guidance for ARIKAYCE to $420 million - $430 million, indicating 15% - 18% growth year-over-year [10]. The stock surged from $76.54 to a 52-week high of $194.70, marking a 154.4% gain [10]. - **Ventyx Biosciences Inc. (VTYX)**: A clinical-stage biotech company developing therapies for autoimmune and neurodegenerative diseases. Ventyx reported positive Phase 2 results for its NLRP3 inhibitor VTX3232, showing strong safety and tolerability [11][13]. The stock rose from $3.01 to a 52-week high of $8.52, a gain of over 183% [14]. - **Inhibrx Biosciences Inc. (INBX)**: Focuses on oncology and rare diseases, announcing positive topline results from its ChonDRAgon study for ozekibart in chondrosarcoma [15]. The stock increased from $18.35 to a 52-week high of $83.78, representing a gain of 356.6% [16]. - **ABIVAX Société Anonyme (ABVX)**: Developing therapies for chronic inflammatory diseases, ABIVAX presented positive Phase 3 data for obefazimod in ulcerative colitis [17]. The stock rose from $7.83 to an all-time high of $106.73, marking a significant gain of 1263% [18]. - **Arrowhead Pharmaceuticals Inc. (ARWR)**: Developing RNAi-based therapies, Arrowhead finalized a licensing agreement with Novartis for ARO-SNCA, with financial terms including a $200 million upfront payment [19][20][21]. The stock increased from $29.70 to a 52-week high of $43.33, representing a gain of over 45% [21]. - **Kodiak Sciences Inc. (KOD)**: Focused on retinal diseases, Kodiak announced positive Phase 1b data for KSI-101, showing significant vision improvements [22][23][24]. The stock climbed from $8.98 to a 52-week high of $21.17, delivering a 135.7% gain [22]. - **Arcutis Biotherapeutics Inc. (ARQT)**: Focused on dermatological treatments, Arcutis reported Q3 net income of $7.4 million, a turnaround from a net loss last year, with revenue up 122% year-over-year [25][26]. The stock rose from $14.99 to a 52-week high of $27.08, representing a gain of over 80% [27]. - **Maze Therapeutics Inc. (MAZE)**: Developing precision therapies for various diseases, Maze announced positive Phase 1 results for MZE782 and secured $150 million in a private placement [28][29]. The stock rose from $11.21 to a new 52-week high of $34.29, returning a gain of 206% [29]. - **Supernus Pharmaceuticals Inc. (SUPN)**: Focused on CNS disorders, Supernus is expected to report Q3 earnings of $0.82 per share and revenue of $180.22 million [30][31]. The stock increased from $38.21 to a 52-week high of $57.65, representing a gain of over 50% [31].

Core Viewpoint - Abivax (NASDAQ:ABVX) is experiencing positive momentum due to promising results from its experimental drug obefazimod for ulcerative colitis, leading to a reaffirmed "Buy" rating and an increased price target from BTIG [1][5]. Company Summary - Abivax is a biotech company focused on innovative treatments for inflammatory diseases, with a current stock price of $86.67, reflecting a 3.28% increase [1][4]. - The company's market capitalization is approximately $6.55 billion, indicating strong investor interest [4]. Drug Development Summary - Obefazimod has shown significant efficacy in treating ulcerative colitis, with patients achieving remission after just eight weeks of treatment, including those who were previously unresponsive to other therapies [2][5]. - The results of obefazimod have been described as "compelling," highlighting its potential as a novel oral treatment for inflammatory bowel disease [3]. Market Activity Summary - The stock has traded between $86.57 and $90.70 on the day, with a 52-week high of $92.91 and a low of $4.77, reflecting active trading and investor engagement [4]. - The success of obefazimod has increased its strategic appeal, particularly in the context of rising mergers and acquisitions within the pharmaceutical sector, suggesting strong interest from larger companies [3][5].