Financial Data and Key Metrics Changes - Global net revenue for Q4 2025 was $90.3 million, representing a 14% growth over Q4 2024, including $83.1 million from Jeuveau and $7.2 million from Evolysse [14][15] - For the full year 2025, global net revenue was $297.2 million, up 12% compared to 2024, marking the sixth consecutive year of double-digit growth [15][11] - Reported gross margin for Q4 was approximately 66%, with adjusted gross margin at approximately 67% [16] - GAAP operating expenses for Q4 were $55.1 million, down from $57.3 million in Q3, while non-GAAP operating expenses were $53 million, compared to $49.7 million in Q3 [17][18] - Non-GAAP operating income for Q4 was $7.1 million, compared to $6.7 million in Q4 2024 [19] Business Line Data and Key Metrics Changes - Jeuveau captured over 14% U.S. market share, continuing to gain share even in a declining procedural environment [9] - Evolysse, introduced in 2025, has over 3,000 customers, expanding the company's presence within accounts [10] - International revenue nearly doubled year-over-year, now representing approximately 8% of total revenue, with strong growth in markets like the U.K. [15][10] Market Data and Key Metrics Changes - The U.S. injectable procedural volumes declined for only the third time in 25 years, yet Evolus achieved 12% revenue growth in 2025 [11] - The neurotoxin market declined mid to upper single digits in 2025, but Jeuveau gained units despite new competition [56] - The filler market is expected to see low single-digit growth, with signs of recovery anticipated [56][88] Company Strategy and Development Direction - Evolus aims to build a global performance beauty company centered on differentiated brands for cash pay consumers, with a focus on expanding its product portfolio [12][26] - The company plans to introduce Estyme in Europe in Q2 2026 and expects FDA approval of Evolysse Sculpt in Q4 2026 [12][26] - Evolus is committed to driving profitable growth, targeting revenue between $450 million to $500 million by 2028 [12] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in achieving sustained profitability beginning in 2026, with a low to mid-single-digit adjusted EBITDA margin expected [12][25] - The company noted that the aesthetic market is showing signs of recovery, particularly in the filler market, with expectations for gradual improvement [56][88] - Management highlighted the importance of customer loyalty programs and the positive feedback received from clinicians regarding product differentiation [32][56] Other Important Information - Evolus has entered into a revolving credit facility providing up to $30 million for working capital needs [21] - The company is not planning to raise equity capital and remains sensitive to dilution [22] Q&A Session Summary Question: Has the growth of Evolus been primarily from early adopters? - Management noted that the customer base is diversifying, with over 3,000 purchasing accounts contributing to revenue growth [30] Question: Can Evolus turn around market growth impacted by macro trends? - Management believes that while macro factors affect the market, there are signs of improvement in the filler market [34] Question: Can you provide details on the rebate program structure? - The rebate program is designed to reward clinics for increased purchases, with eligibility based on quarterly purchase volumes [42][43] Question: How is the overall marketing strategy described for 2026? - The marketing strategy includes digital advertising and co-promotions with beauty brands, tailored to individual clinics [46][47] Question: What are the assumptions regarding competitive launches in guidance? - Management acknowledged the expected launch of new competitors in 2026 but remains confident in their product differentiation and market position [62][80]