TABLE OF CONTENTS As filed with the Securities and Exchange Commission on June 18, 2024. Registration No. 333-280068 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 AMENDMENT NO. 1 TO FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Alumis Inc. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Classification Code Number) Delaware 2834 86-1771129 (I.R.S. Employer Identifica ...

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on June 7, 2024. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Alumis Inc. WASHINGTON, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Alumis Inc. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Classification Code Number) Delaware 2834 86-1771129 (I.R.S. Employer Identification Number) 2 ...