CytomX Therapeutics FY Conference Summary Company Overview - **Company**: CytomX Therapeutics (NasdaqGS:CTMX) - **Industry**: Oncology-focused biotechnology - **Location**: South San Francisco - **Key Personnel**: - Sean McCarthy (CEO) - Chris Ogden (CFO) - Rachel Lester (Chief Business Officer) - Wayne Chu (Chief Medical Officer) Core Points and Arguments Pipeline and Technology - CytomX has developed a unique Probody therapeutic platform aimed at masking antibodies to improve therapeutic windows in oncology [3][4] - The company is focused on two main clinical programs: - **Vasetatag masatikan (Vaseta M)**: An EpCAM-targeting Probody Topo-1 ADC for colorectal cancer [3][5] - **CX801**: A Probody version of interferon alpha-2b for melanoma [3][6] Financial Position - CytomX is well-funded, with cash reserves extending into Q2 2027, excluding potential milestones or new business developments [4] Vaseta M Program - The phase one study for Vaseta M is expanding to over 100 patients, with data updates expected by the end of Q1 2026 [8][19] - Initial data showed a 28% confirmed overall response rate and 94% disease control in late-line colorectal cancer patients [14][17] - The market for colorectal cancer is significant, with 1.9 million patients diagnosed annually, projected to exceed 3 million by 2040, and a $5 billion market opportunity in the U.S. for late-line treatment [10][22] Safety and Efficacy - Vaseta M demonstrated a favorable safety profile with no classic EpCAM toxicities, which have historically limited other EpCAM-targeting therapies [15][18] - The most common adverse event reported was grade 3 diarrhea, occurring in 21-22% of patients, which the company is actively investigating [19][36] Future Development Plans - CytomX aims to initiate a combination study of Vaseta M with bevacizumab to explore earlier lines of treatment [20][30] - The company plans to expand into other tumor types where EpCAM is expressed, potentially leading to a pan-tumor agnostic label [21][22] CX801 Program - CX801 is being developed as a novel immunotherapy for melanoma, particularly in patients who have progressed on checkpoint inhibitors [23][26] - The program aims to harness the activity of interferon alpha-2b while minimizing systemic toxicity through masking strategies [24][25] - Initial data from the combination with Keytruda is expected by the end of 2026 [30] Additional Important Content - CytomX has established partnerships with major pharmaceutical companies, including BMS, Amgen, and Moderna, enhancing its business development capabilities [4] - The company emphasizes the importance of understanding the etiology of adverse events, particularly gastrointestinal toxicities, to optimize patient management [37][38] - The strategic decision to focus on colorectal cancer was based on the abundance of the EpCAM target and the unmet medical need in this area [40][41] Conclusion CytomX Therapeutics is positioned at the forefront of innovation in oncology with its differentiated pipeline and strategic focus on unmet needs in colorectal cancer and melanoma. The upcoming data releases and ongoing studies are critical for validating the efficacy and safety of its lead programs, which could significantly impact the treatment landscape in these areas.

Financial Data and Key Metrics Changes - As of September 30, 2025, the company reported cash, cash equivalents, and investments of $143.6 million, down from $158.1 million at the end of Q2 2025, indicating a decrease in liquidity [19] - Total revenue for Q3 2025 was $6 million, a significant decline from $33.4 million in Q3 2024, primarily due to the completion of performance obligations in the Bristol Myers Squibb collaboration [19] - Operating expenses decreased to $21.7 million in Q3 2025 from $29.3 million in Q3 2024, with R&D expenses at $15.3 million, down by $6.1 million year-over-year [20] Business Line Data and Key Metrics Changes - The company is advancing its lead drug candidate, CX-2051, which targets colorectal cancer, with promising interim Phase I data showing robust clinical activity and a preliminary median progression-free survival of 5.8 months [9][10] - CX-2051 is currently in the expansion phase of its Phase I study, with total enrollment expected to reach about 100 patients by Q1 2026 [11] - CX-801, another program in development for advanced melanoma, has shown promising initial biomarker data, indicating robust interferon signaling within the tumor microenvironment [16] Market Data and Key Metrics Changes - Colorectal cancer (CRC) represents a significant unmet need, with over 1.9 million new cases annually worldwide, projected to exceed 3 million by 2040 [5] - The company aims to position CX-2051 as a potential new standard of care in CRC, a market with substantial opportunities given the limitations of current treatments [6] Company Strategy and Development Direction - The company is focused on building an integrated commercial-stage organization around its innovative drug candidates, particularly CX-2051 and CX-801, while exploring additional indications for CX-2051 [12][22] - The strategy includes initiating a Phase IB study with the anti-VEGF antibody bevacizumab in Q1 2026, aiming to broaden the application of CX-2051 in earlier lines of CRC therapy [11][31] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the potential of CX-2051 to outperform current standards of care in late-line CRC treatment, with an integrated confirmed response rate of 28% observed in early data [25] - The company remains optimistic about the differentiation of its drug candidates and their potential to address significant unmet medical needs in oncology [28][42] Other Important Information - The company completed a $100 million financing earlier in the year, positioning it to advance CX-2051 towards later-phase development [18] - Management highlighted the importance of ongoing discussions with the FDA regarding regulatory strategy and potential registrational paths for CX-2051 [41] Q&A Session Summary Question: Expectations for CX-2051 readout and ORR - Management indicated an integrated confirmed response rate of 28% and expressed optimism about the potential for improvement as data matures [25][26] Question: Enrollment feedback and trial partner insights - Management attributed increased enrollment to high interest from investigators and patients, with ongoing focus on managing adverse events like diarrhea [27] Question: Strategy for combination approach with bevacizumab - The initial strategy involves exploring multiple doses of CX-2051 in combination with bevacizumab, aiming to broaden the drug's application in earlier lines of therapy [30][31] Question: Regulatory strategy and interactions with the FDA - Management anticipates discussions with the FDA regarding registrational plans in 2026, with ongoing evaluation of data to inform strategy [41] Question: Potential for CX-2051 in other tumor types - Management expressed enthusiasm for exploring additional indications for CX-2051, including gastric, endometrial, and pancreatic cancers, while balancing development plans in CRC [37]

Financial Data and Key Metrics Changes - CytomX Therapeutics announced a financing of $100 million with a leading group of healthcare investors, which underscores the confidence in the company's progress and potential [3][7] - The company reported a 28% confirmed overall response rate and a 94% disease control rate for CX-2051 in metastatic colorectal cancer, with a preliminary progression-free survival of 5.8 months [11][26] Business Line Data and Key Metrics Changes - CX-2051, an antibody-drug conjugate targeting EpCAM, has shown promising results in a Phase I clinical trial focused exclusively on metastatic colorectal cancer [11][19] - The trial included a heavily pretreated patient population, with a median of four prior lines of therapy, indicating the drug's potential effectiveness in late-line treatment settings [21] Market Data and Key Metrics Changes - Colorectal cancer is a significant global health issue, with approximately 1.9 million new cases diagnosed annually, expected to rise to over 3 million in the coming decades [7][8] - The current five-year survival rate for metastatic colorectal cancer is only 13%, highlighting the urgent need for innovative treatment options [8] Company Strategy and Development Direction - The company aims to position CX-2051 as a new standard of care in late-line colorectal cancer treatment, with plans to expand its use into earlier lines of therapy [36][37] - There is a vision to explore CX-2051's potential in other solid tumors, leveraging the high expression of EpCAM across various cancer types [37][38] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about the drug's performance and its potential to transform colorectal cancer treatment, emphasizing the inadequacy of current standard therapies [36][37] - The company plans to generate additional data from ongoing expansions and engage with regulatory authorities to expedite the development process [48][62] Other Important Information - The safety profile of CX-2051 has been favorable, with no dose-limiting toxicities observed to date, and the adverse events reported were manageable and reversible [30][31] - The company is exploring prophylactic strategies to manage gastrointestinal toxicities associated with the treatment [66] Q&A Session Summary Question: What differences are seen between stable disease and responders in terms of baseline characteristics? - Management noted the overall impressive disease control rate and response rate, indicating that they will continue to analyze patient characteristics that may influence outcomes [44][45] Question: What is the current development strategy for pivotal endpoints and moving into earlier lines? - The focus is on generating data from expansion cohorts, with plans to discuss optimal paths for Phase II and potentially Phase III trials with regulatory authorities [48][62] Question: Can you provide details on the management of serious adverse events? - The safety profile is encouraging, and while specific patient details cannot be disclosed, the adverse events reported align with the overall profile [54][55] Question: Are there plans for accelerated development or breakthrough designations? - Discussions with regulatory authorities are anticipated, and the expansion data will be crucial for these conversations [62] Question: Is there evidence of high EpCAM expression in earlier stage patients? - EpCAM is well-established as a CRC target, and its expression is consistent throughout the disease's natural history, supporting its use in earlier treatment lines [71][72] Question: Will higher dosing be considered based on emerging signals? - While the current dose levels are being expanded, the company is cautious about escalating doses without observing dose-limiting toxicities [75][76]