Group 1: Avidity Biosciences and Novartis Deal - Avidity Biosciences (NASDAQ:RNA) stock surged 42% in premarket trading following Novartis (NYSE:NVS) agreeing to acquire the company for $12 billion [3][4] - Novartis will pay $72 per share in cash, which represents a 46% premium over Avidity's closing price on the previous Friday [4] - RBC Capital Markets analyst Luca Issi described the acquisition as a "bullish signal for biotech" [4] Group 2: Dyne Therapeutics - Dyne Therapeutics (DYN) shares increased by 21% in premarket trading, with Jefferies analyst Andrew Tsai indicating that the company is likely to benefit from Novartis's acquisition of Avidity [4] Group 3: HSBC and Madoff Fraud Case - HSBC is facing a $1.1 billion loss related to the Bernard Madoff investment fraud case, as a Luxembourg court ruled against its local unit [6] - The bank will record a provision in its third-quarter results following the court's decision, which upheld part of a claim for securities but overturned the cash restitution part [6][7] - HSBC shares fell by as much as 2% in early trading due to this ruling [7] Group 4: Market Trends - HIVE Digital Technologies (NASDAQ:HIVE) shares rose by 6% after the company reported exceeding 22 exahash per second in global bitcoin-mining capacity, reflecting a 267% year-to-date growth [8]